Clomipramine hydrochloride, Tricyclic antidepressant agent (ab143213)

Overview

  • Product name

    Clomipramine hydrochloride, Tricyclic antidepressant agent
  • Description

    Tricyclic antidepressant agent
  • Biological description

    Tricyclic antidepressant agent. Selective α1-adrenoceptor antagoinst (Ki values are 3 and 525 nM for α1 and α2 respectively. SERT, NET and DAT blocker (Ki values are 0.14, 54 and 3 nM respectively). Dopamine receptor antagonist (Ki values are 219, 162 and 30 for D1, D2 and D3 respectively). Serotonin receptor antagonist (Ki values are 36, 65 and 85 nM for 5-HT2A, 5-HT2C and 5-HT3 respectively). H1 receptor antagonist (Ki = 31 nM). Non-selective mAchR antagonist (Ki = 37 nM). Shows antidepressant effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    17321-77-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Ferjan I & Lipnik-Štangelj M Chronic pain treatment: the influence of tricyclic antidepressants on serotonin release and uptake in mast cells. Mediators Inflamm 2013:340473 (2013). Read more (PubMed: 23710115) »
  • Ookubo M  et al. Antidepressants and mood stabilizers effects on histone deacetylase expression in C57BL/6 mice: Brain region specific changes. J Psychiatr Res 47:1204-14 (2013). Read more (PubMed: 23777937) »
  • Yonar D  et al. Interaction of antidepressant drug, clomipramine, with model and biological stratum corneum membrane as studied by electron paramagnetic resonance. J Pharm Sci 102:3762-72 (2013). Read more (PubMed: 23925997) »

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