Key features and details
- Selective, irreversible MAO-A inhibitor. Potent σ1 receptor inhibitor.
- CAS Number: 17780-75-5
- Purity: > 98%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameClorgyline hydrochloride, MAO-A inhibitor
DescriptionSelective, irreversible MAO-A inhibitor. Potent σ1 receptor inhibitor.
Biological descriptionSelective, irreversible MAO-A inhibitor (Ki values are 0.054 and 58 μM for MAO-A and MAO-B respectively). Potent σ1 receptor inhibitor (IC50 = 31 nM). Lysine-specific demethylase 1 inhibitor. Centrally active in vivo.
Chemical name3-(2,4-Dichlorophenoxy)-N-methyl-N-prop-2-ynylpropan-1-amine hydrochloride
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab145646 has been referenced in 1 publication.
- Nicholatos JW et al. Nicotine promotes neuron survival and partially protects from Parkinson's disease by suppressing SIRT6. Acta Neuropathol Commun 6:120 (2018). PubMed: 30409187