Overview

  • Product name

    Clorgyline hydrochloride, MAO-A inhibitor
  • Description

    Selective, irreversible MAO-A inhibitor. Potent σ1 receptor inhibitor.
  • Biological description

    Selective, irreversible MAO-A inhibitor (Ki values are 0.054 and 58 μM for MAO-A and MAO-B respectively). Potent σ1 receptor inhibitor (IC50 = 31 nM). Lysine-specific demethylase 1 inhibitor. Centrally active in vivo.
  • Purity

    > 98%
  • CAS Number

    17780-75-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-(2,4-Dichlorophenoxy)-N-methyl-N-prop-2-ynylpropan-1-amine hydrochloride
  • Molecular weight

    308.63
  • Molecular formula

    C13H15Cl2NO.HCl
  • PubChem identifier

    28767
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(CCCOC1=C(C=C(C=C1)Cl)Cl)CC#C.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Hynson RM  et al. Conformational changes in monoamine oxidase A in response to ligand binding or reduction. Biochim Biophys Acta 1672:60-6 (2004). Read more (PubMed: 15056494) »
  • Mazzio E  et al. Inflammation and inducible nitric oxide synthase have no effect on monoamine oxidase activity in glioma cells. Biochem Pharmacol 65:1719-27 (2003). Read more (PubMed: 12754108) »
  • Fone KC  et al. Characterization of the 5-HT receptor subtypes involved in the motor behaviours produced by intrathecal administration of 5-HT agonists in rats. Br J Pharmacol 103:1547-55 (1991). Read more (PubMed: 1832068) »

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