Overview

  • Product name

    Closantel sodium, Antiparasitic agent
  • Description

    Antiparasitic agent
  • Biological description

    Antiparasitic agent. Inhibits CpxRAP and HK. Selectively inhibits OvCHT1 in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    61438-64-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[5-Chloro-4-[(4-chlorophenyl)-cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide sodium
  • Molecular weight

    686.06
  • Molecular formula

    C22H13Cl2I2N2NaO2
  • PubChem identifier

    68534624
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC(=C(C=C1NC(=O)C2=CC(=CC(=C2O)I)I)Cl)C(C#N)C3=CC=C(C=C3)Cl.[Na]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Matsubara K  et al. An improved thyroid hormone reporter assay to determine the thyroid hormone-like activity of amiodarone, bithionol, closantel and rafoxanide. Toxicol Lett 208:30-5 (2012). Read more (PubMed: 22015988) »
  • Garner AL  et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem 54:3963-72 (2011). Read more (PubMed: 21534605) »
  • Fleischer R  et al. Purification, reconstitution, and characterization of the CpxRAP envelope stress system of Escherichia coli. J Biol Chem 282:8583-93 (2007). Read more (PubMed: 17259177) »
See 1 Publication for this product

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