Overview

  • Product name

    Cloxacillin sodium, Antibiotic agent
  • Description

    Antibiotic agent
  • Biological description

    Antibiotic agent. Inhibits the biosynthesis of cell wall mucopeptides. Shows bacteriocidal effects against β-lactamase bacteria in vivo. Orally active.
  • CAS Number

    7081-44-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Sodium (2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate
  • Molecular weight

    475.88
  • Molecular formula

    C19H17ClN3NaO5S.H2O
  • PubChem identifier

    23675743
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM, in DMSO to 100 mM and in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].O.[Na+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Zeng K  et al. Development of a rapid multi-residue assay for detecting ß-lactams using penicillin binding protein 2x*. Biomed Environ Sci 26:100-9 (2013). Read more (PubMed: 23336133) »
  • Sandberg A  et al. Intra- and extracellular activities of dicloxacillin and linezolid against a clinical Staphylococcus aureus strain with a small-colony-variant phenotype in an in vitro model of THP-1 macrophages and an in vivo mouse peritonitis model. Antimicrob Agents Chemother 55:1443-52 (2011). Read more (PubMed: 21282430) »
  • Murillo O  et al. Intracellular antimicrobial activity appearing as a relevant factor in antibiotic efficacy against an experimental foreign-body infection caused by Staphylococcus aureus. J Antimicrob Chemother 64:1062-6 (2009). Read more (PubMed: 19744977) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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