Clozapine, Atypical antipsychotic (ab120019)

Submit a review Q&A (1)References (2)

Overview

  • Product name

    Clozapine, Atypical antipsychotic

  • Description

    Atypical antipsychotic

  • Biological description

    Atypical antipsychotic compound. Broad range of actions including antagonism at D4, D2, 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 receptors. Also agonist at muscarinic receptors.

  • Purity

    > 98%

  • CAS Number

    5786-21-0

  • Chemical structure

    Chemical Structure

Properties

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (2)

Publishing research using ab120019? Please let us know so that we can cite the reference in this datasheet.

ab120019 has been referenced in 2 publications.

  • Nikiforuk A  et al. The 5-hydroxytryptamine (serotonin) receptor 6 agonist EMD 386088 ameliorates ketamine-induced deficits in attentional set shifting and novel object recognition, but not in the prepulse inhibition in rats. J Psychopharmacol 27:469-76 (2013). PubMed: 23479455
  • Greenhill SD & Jones RS Diverse antiepileptic drugs increase the ratio of background synaptic inhibition to excitation and decrease neuronal excitability in neurones of the rat entorhinal cortex in vitro. Neuroscience 167:456-74 (2010). PubMed: 20167261

Customer reviews and Q&As

Show All Reviews Q&A
Submit a review Submit a question

Question

Customer kindly contacted us regarding ab120019 solubility limits after diluting in 2 eq. HCL to 50mM. He is injecting into rodents but needs a more dilute HCL concentration than 50mM, so he needs to dilute further in saline prior to injection. He is wondering how if the Clozapine will remain soluble with further dilution in saline.

Read More
Answer



Our chemists have checked the solubility of 50mM Clozapine in 2 eq. HCl and also further dilutions in saline. We can confirm that the solubility was maintained for further dilutions as follows:

50mM in 2 eq. HCl (Stock solution)

25mM 1:1 dilution in saline

10mM 1:4 dilution in saline

5mM 1:9 dilution in saline

Saline is 0.9% NaCl unbuffered in de-ionized water.

Read More

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com