Name: Clozapine, Atypical antipsychotic
SKU: ab120019

Datasheet
References (2)

Product name

Clozapine, Atypical antipsychotic
Description

Atypical antipsychotic
Biological description

Atypical antipsychotic compound. Broad range of actions including antagonism at D₄, D₂, 5-HT_2A, 5-HT_2C, 5-HT₃, 5-HT₆, and 5-HT₇ receptors. Also agonist at muscarinic receptors.
Purity

> 98%
CAS Number

5786-21-0
Chemical structure

Chemical name

8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Molecular weight

326.83
Molecular formula

C₁₈H₁₉ClN₄
PubChem identifier

2818
Storage instructions

Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overview

Soluble in 2 eq. HCl to 50 mM
Handling

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
SMILES

CN1CCN(CC1)C2=Nc4cc(Cl)ccc4Nc3ccccc23
Source

Synthetic
Research areas

This product has been referenced in:

Josselyn SA et al. Behavioral effects of clozapine and dopamine receptor subtypes. Neurosci Biobehav Rev 21:531-58 (1997). Read more (PubMed: 9353791) »
Brunello N et al. New insights into the biology of schizophrenia through the mechanism of action of clozapine. Neuropsychopharmacology 13:177-213 (1995). Read more (PubMed: 8602893) »

See all 2 Publications for this product

Publishing research using ab120019? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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Question

Customer kindly contacted us regarding ab120019 solubility limits after diluting in 2 eq. HCL to 50mM. He is injecting into rodents but needs a more dilute HCL concentration than 50mM, so he needs to dilute further in saline prior to injection. He is wondering how if the Clozapine will remain soluble with further dilution in saline.

Abcam community

Verified customer

Asked on Jan 15 2013

Answer

Our chemists have checked the solubility of 50mM Clozapine in 2 eq. HCl and also further dilutions in saline. We can confirm that the solubility was maintained for further dilutions as follows:

50mM in 2 eq. HCl (Stock solution)

25mM 1:1 dilution in saline

10mM 1:4 dilution in saline

5mM 1:9 dilution in saline

Saline is 0.9% NaCl unbuffered in de-ionized water.

Abcam Scientific Support

Answered on Jan 15 2013

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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Clozapine, Atypical antipsychotic (ab120019)

Overview

Properties

Datasheets and documents

References

This product has been referenced in:

Customer reviews and Q&As