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    clozapine-atypical-antipsychotic-ab120019.pdf

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Clozapine, Atypical antipsychotic (ab120019)

  • Datasheet
  • SDS
  • COA
Submit a review Q&A (1)References (3)

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Chemical Structure - Clozapine, Atypical antipsychotic (ab120019)

    Key features and details

    • Atypical antipsychotic
    • CAS Number: 5786-21-0
    • Soluble in 2 eq. HCl to 50 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      Clozapine, Atypical antipsychotic
    • Description

      Atypical antipsychotic
    • Biological description

      Atypical antipsychotic compound. Broad range of actions including antagonism at D4, D2, 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 receptors. Also agonist at muscarinic receptors.

    • CAS Number

      5786-21-0
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
    • Molecular weight

      326.83
    • Molecular formula

      C18H19ClN4
    • PubChem identifier

      2818
    • Storage instructions

      Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in 2 eq. HCl to 50 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Toxic, refer to SDS for further information

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CN1CCN(CC1)C2=Nc4cc(Cl)ccc4Nc3ccccc23
    • Source

      Synthetic

    • Research areas

      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • GPCR
      • Dopamine Receptors
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • GPCR
      • Serotonin Receptors
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • GPCR
      • Muscarinic Receptors
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Muscarinic
      • Non-selective
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Muscarinic
      • Non-selective
      • Agonists
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Serotonin
      • Non-selective
      • Antagonists
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Dopamine
      • Non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Alzheimer's Disease
      • Muscarinic
      • Non-selective
      • Biochemicals
      • Research Area
      • Alzheimer's Disease
      • Muscarinic
      • Non-selective
      • Agonists
      • Biochemicals
      • Research Area
      • Depression
      • Serotonin
      • Non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Obesity
      • Muscarinic
      • Non-selective
      • Biochemicals
      • Research Area
      • Obesity
      • Muscarinic
      • Non-selective
      • Agonists
      • Biochemicals
      • Research Area
      • Obesity
      • Serotonin
      • Non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Parkinson's Disease
      • Dopamine
      • Non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Parkinson's Disease
      • Serotonin
      • Non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Respiratory disease
      • Muscarinic
      • Non-selective
      • Biochemicals
      • Research Area
      • Respiratory disease
      • Muscarinic
      • Non-selective
      • Agonists
      • Biochemicals
      • Research Area
      • Schizophrenia
      • Dopamine
      • Non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Schizophrenia
      • Muscarinic
      • Non-selective
      • Biochemicals
      • Research Area
      • Schizophrenia
      • Muscarinic
      • Non-selective
      • Agonists
      • Biochemicals
      • Research Area
      • Schizophrenia
      • Serotonin
      • Non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Stress / Anxiety
      • Dopamine
      • Non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Stress / Anxiety
      • Serotonin
      • Non-selective
      • Antagonists

    Images

    • Chemical Structure - Clozapine, Atypical antipsychotic (ab120019)
      Chemical Structure - Clozapine, Atypical antipsychotic (ab120019)
      2D chemical structure image of ab120019, Clozapine, Atypical antipsychotic

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (3)

    Publishing research using ab120019? Please let us know so that we can cite the reference in this datasheet.

    ab120019 has been referenced in 3 publications.

    • Fijal K  et al. Co-administration of 5-HT6 receptor antagonists with clozapine, risperidone, and a 5-HT2A receptor antagonist: effects on prepulse inhibition in rats. Psychopharmacology (Berl) 231:269-81 (2014). Rat . PubMed: 23954911
    • Nikiforuk A  et al. The 5-hydroxytryptamine (serotonin) receptor 6 agonist EMD 386088 ameliorates ketamine-induced deficits in attentional set shifting and novel object recognition, but not in the prepulse inhibition in rats. J Psychopharmacol 27:469-76 (2013). PubMed: 23479455
    • Greenhill SD & Jones RS Diverse antiepileptic drugs increase the ratio of background synaptic inhibition to excitation and decrease neuronal excitability in neurones of the rat entorhinal cortex in vitro. Neuroscience 167:456-74 (2010). PubMed: 20167261

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    Question

    Customer kindly contacted us regarding ab120019 solubility limits after diluting in 2 eq. HCL to 50mM. He is injecting into rodents but needs a more dilute HCL concentration than 50mM, so he needs to dilute further in saline prior to injection. He is wondering how if the Clozapine will remain soluble with further dilution in saline.

    Read More

    Abcam community

    Verified customer

    Asked on Jan 15 2013

    Answer



    Our chemists have checked the solubility of 50mM Clozapine in 2 eq. HCl and also further dilutions in saline. We can confirm that the solubility was maintained for further dilutions as follows:

    50mM in 2 eq. HCl (Stock solution)

    25mM 1:1 dilution in saline

    10mM 1:4 dilution in saline

    5mM 1:9 dilution in saline

    Saline is 0.9% NaCl unbuffered in de-ionized water.

    Read More

    Abcam Scientific Support

    Answered on Jan 15 2013

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
    For licensing inquiries, please contact partnerships@abcam.com

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