Key features and details
- Atypical antipsychotic
- CAS Number: 5786-21-0
- Purity: > 98%
- Soluble in 2 eq. HCl to 50 mM
- Form / State: Solid
- Source: Synthetic
Product nameClozapine, Atypical antipsychotic
Atypical antipsychotic compound. Broad range of actions including antagonism at D4, D2, 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 receptors. Also agonist at muscarinic receptors.
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in 2 eq. HCl to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120019 has been referenced in 3 publications.
- Fijal K et al. Co-administration of 5-HT6 receptor antagonists with clozapine, risperidone, and a 5-HT2A receptor antagonist: effects on prepulse inhibition in rats. Psychopharmacology (Berl) 231:269-81 (2014). Rat . PubMed: 23954911
- Nikiforuk A et al. The 5-hydroxytryptamine (serotonin) receptor 6 agonist EMD 386088 ameliorates ketamine-induced deficits in attentional set shifting and novel object recognition, but not in the prepulse inhibition in rats. J Psychopharmacol 27:469-76 (2013). PubMed: 23479455
- Greenhill SD & Jones RS Diverse antiepileptic drugs increase the ratio of background synaptic inhibition to excitation and decrease neuronal excitability in neurones of the rat entorhinal cortex in vitro. Neuroscience 167:456-74 (2010). PubMed: 20167261