Clozapine N-oxide, Metabolite of Clozapine (ab141704)
Key features and details
- Metabolite of Clozapine
- CAS Number: 34233-69-7
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Clozapine N-oxide, Metabolite of Clozapine -
Description
Metabolite of Clozapine -
Biological description
Metabolite of atypical antipsychotic Clozapine (ab120019). Active in vitro and in vivo.
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Purity
> 99% -
CAS Number
34233-69-7 -
Chemical structure
Properties
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Chemical name
8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide -
Molecular weight
342.83 -
Molecular formula
C18H19ClN4O -
PubChem identifier
36727 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2O)C=C(C=C4)Cl -
Source
Synthetic
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Research areas
Associated products
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Alternative Versions
Images
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Chemical Structure - Clozapine N-oxide, Metabolite of Clozapine (ab141704)2D chemical structure image of ab141704, Clozapine N-oxide, Metabolite of Clozapine
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (17)
ab141704 has been referenced in 17 publications.
- Horii-Hayashi N & Nishi M Protocol for behavioral tests using chemogenetically manipulated mice. STAR Protoc 2:100418 (2021). PubMed: 33899009
- Ma H et al. Amygdala-hippocampal innervation modulates stress-induced depressive-like behaviors through AMPA receptors. Proc Natl Acad Sci U S A 118:N/A (2021). PubMed: 33526688
- Biglari N et al. Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nat Neurosci 24:913-929 (2021). PubMed: 34002087
- Borgmann D et al. Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell Metab 33:1466-1482.e7 (2021). PubMed: 34043943
- Valyear MD et al. Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts. Nat Commun 11:3764 (2020). PubMed: 32724058