Clozapine N-oxide, Metabolite of Clozapine (ab141704)
- Datasheet
- References (5)
Overview
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Product nameClozapine N-oxide, Metabolite of Clozapine
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DescriptionMetabolite of Clozapine
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Biological descriptionMetabolite of atypical antipsychotic Clozapine (ab120019). Active in vitro and in vivo.
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Purity> 99%
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CAS Number34233-69-7
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Chemical structure
Properties
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Chemical name8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide
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Molecular weight342.83
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Molecular formulaC18H19ClN4O
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PubChem identifier36727
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Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
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Solubility overviewSoluble in water to 100 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILESCN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2O)C=C(C=C4)Cl
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Source
Synthetic
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Research areas
References
This product has been referenced in:
- Heiser P et al. Effects of clozapine and its metabolites on the 5-HT2 receptor system in cortical and hippocampal cells in vitro. Prog Neuropsychopharmacol Biol Psychiatry 28:297-302 (2004). Read more (PubMed: 14751426) »
- Chang WH et al. Reversible metabolism of clozapine and clozapine N-oxide in schizophrenic patients. Prog Neuropsychopharmacol Biol Psychiatry 22:723-39 (1998). Read more (PubMed: 9723115) »
- Jann MW et al. Pharmacokinetics and pharmacodynamics of clozapine. Clin Pharmacokinet 24:161-76 (1993). Read more (PubMed: 8453823) »
