Overview

  • Product name

  • Description

    Rabbit polyclonal to CMKLR1
  • Host species

    Rabbit
  • Specificity

    ab230442 recognizes endogenous levels of CMKLR1 protein.
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
    Predicted to work with: Pig
  • Immunogen

    Synthetic peptide corresponding to Human CMKLR1 (internal sequence) conjugated to keyhole limpet haemocyanin.
    Database link: Q99788

  • Positive control

    • WB: Jurkat and HepG2 whole cell lysate (ab7900); Mouse liver whole cell cell lysate; rat liver whole cell lysate. IHC-P: Human mesothelium and breast cancer tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab230442 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 42 kDa.
IHC-P 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Orphan receptor. Could be a chemotactic peptide receptor. May have a function in bone metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
  • Tissue specificity

    Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Developmental stage

    Expressed during bone development.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CHEMERINR antibody
    • Chemokine like receptor 1 antibody
    • Chemokine-like receptor 1 antibody
    • CHEMR23 antibody
    • CMKLR1 antibody
    • CML1_HUMAN antibody
    • DEZ antibody
    • G protein coupled receptor ChemR23 antibody
    • G protein coupled receptor DEZ antibody
    • G-protein coupled receptor ChemR23 antibody
    • G-protein coupled receptor DEZ antibody
    • Orphan G protein coupled receptor antibody
    • Orphan G protein coupled receptor Dez antibody
    • Resolvin E1 receptor antibody
    • RVER1 antibody
    see all

Images

  • All lanes : Anti-CMKLR1 antibody (ab230442) at 1/500 dilution

    Lane 1 : Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate
    Lane 2 : HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate
    Lane 3 : Mouse liver whole cell lysate
    Lane 4 : Rat liver whole cell lysate

    Developed using the ECL technique.

    Predicted band size: 42 kDa

  • Formalin-fixed, paraffin-embedded human breast cancer tissue stained for CMKLR1 with ab230442 at 1/100 dilution in immunohistochemical analysis. Incubated with the primary antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.

  • Formalin-fixed, paraffin-embedded human mesothelium tissue stained for CMKLR1 with ab230442 at 1/100 dilution in immunohistochemical analysis.

References

ab230442 has not yet been referenced specifically in any publications.

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