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    cmklr1-antibody-n-terminal-ab150491.pdf

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Signal Transduction Signaling Pathway G Protein Signaling GPCR
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Anti-CMKLR1 antibody - N-terminal (ab150491)

  • Datasheet
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CMKLR1 antibody - N-terminal (ab150491)

    Key features and details

    • Rabbit polyclonal to CMKLR1 - N-terminal
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

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    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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    Overview

    • Product name

      Anti-CMKLR1 antibody - N-terminal
      See all CMKLR1 primary antibodies
    • Description

      Rabbit polyclonal to CMKLR1 - N-terminal
    • Host species

      Rabbit
    • Specificity

      BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except FZD6 (11%).
    • Tested applications

      Suitable for: IHC-Pmore details
    • Species reactivity

      Reacts with: Human
    • Immunogen

      An 18 amino acid synthetic peptide from the N-terminal extracellular domain of Human CMKLR1 (NP_004063.1).

    • Positive control

      • Human thymus tissue
    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C.
    • Storage buffer

      Preservative: 0.1% Sodium azide
      Constituent: 99% PBS
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Signal Transduction
      • Signaling Pathway
      • G Protein Signaling
      • GPCR
      • Signal Transduction
      • Cytoskeleton / ECM
      • Extracellular Matrix
      • Structures
      • Bone
      • Cell Biology
      • Other Antibodies
      • Other Antibodies

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab150491 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P
    Use a concentration of 7 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
    Notes
    IHC-P
    Use a concentration of 7 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

    Target

    • Function

      Orphan receptor. Could be a chemotactic peptide receptor. May have a function in bone metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
    • Tissue specificity

      Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands.
    • Sequence similarities

      Belongs to the G-protein coupled receptor 1 family.
    • Developmental stage

      Expressed during bone development.
    • Cellular localization

      Cell membrane.
    • Target information above from: UniProt accession Q99788 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 1240 Human
      • Omim: 602351 Human
      • SwissProt: Q99788 Human
      • Unigene: 197143 Human
      • Alternative names

        • CHEMERINR antibody
        • Chemokine like receptor 1 antibody
        • Chemokine-like receptor 1 antibody
        • CHEMR23 antibody
        • CMKLR1 antibody
        • CML1_HUMAN antibody
        • DEZ antibody
        • G protein coupled receptor ChemR23 antibody
        • G protein coupled receptor DEZ antibody
        • G-protein coupled receptor ChemR23 antibody
        • G-protein coupled receptor DEZ antibody
        • Orphan G protein coupled receptor antibody
        • Orphan G protein coupled receptor Dez antibody
        • Resolvin E1 receptor antibody
        • RVER1 antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CMKLR1 antibody - N-terminal (ab150491)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CMKLR1 antibody - N-terminal (ab150491)
        Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human thymus tissue labelling CMKLR1 with ab150491 at 7 µg/ml

      Protocols

      • Immunohistochemistry protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (1)

      Publishing research using ab150491? Please let us know so that we can cite the reference in this datasheet.

      ab150491 has been referenced in 1 publication.

      • Jannaway M  et al. Resolvin E1, resolvin D1 and resolvin D2 inhibit constriction of rat thoracic aorta and human pulmonary artery induced by the thromboxane mimetic U46619. Br J Pharmacol 175:1100-1108 (2018). PubMed: 29352769

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