Anti-CMPK2 antibody (ab194567)
Key features and details
- Mouse polyclonal to CMPK2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-CMPK2 antibody
See all CMPK2 primary antibodies -
Description
Mouse polyclonal to CMPK2 -
Host species
Mouse -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment (GST-tag) corresponding to Human CMPK2 aa 150-250. (NP_997198).
Database link: Q5EBM0 -
Positive control
- Jurkat cell lysate; recombinant Human CMPK2 protein (immunogen).
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
Constituent: 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab194567 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/2500. Predicted molecular weight: 49 kDa.
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Notes |
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WB
1/500 - 1/2500. Predicted molecular weight: 49 kDa. |
Target
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Function
May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. -
Tissue specificity
Among all investigated tumors, leukemia cells show the most abundant expression. -
Sequence similarities
Belongs to the thymidylate kinase family. -
Cellular localization
Mitochondrion. - Information by UniProt
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Database links
- Entrez Gene: 129607 Human
- Omim: 611787 Human
- SwissProt: Q5EBM0 Human
- Unigene: 7155 Human
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Alternative names
- 1200004E04Rik antibody
- Cmpk2 antibody
- CMPK2_HUMAN antibody
see all
Images
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Anti-CMPK2 antibody (ab194567) at 1/500 dilution + Jurkat cell lysate at 50 µg
Developed using the ECL technique.
Predicted band size: 49 kDa -
Anti-CMPK2 antibody (ab194567) at 1/1000 dilution + recombinant Human CMPK2 protein (immunogen) at 0.2 µg
Developed using the ECL technique.
Predicted band size: 49 kDaPredicted MWt of immunogen: 37.11 KDa.
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab194567 has been referenced in 2 publications.
- Lai JH et al. Mitochondrial CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways. iScience 24:102498 (2021). PubMed: 34142025
- Zhang X et al. Pigment epithelium-derived factor facilitates NLRP3 inflammasome activation through downregulating cytidine monophosphate kinase 2: A potential treatment strategy for missed abortion. Int J Mol Med 45:1436-1446 (2020). PubMed: 32323732