Product nameAnti-CNBP antibody
See all CNBP primary antibodies
DescriptionRabbit polyclonal to CNBP
Tested applicationsSuitable for: ICC/IF, WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Orangutan
- WB: RT4, U-251 MG cells, Human liver and tonsil. IF: SH-SY5Y cells.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol, PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab272676 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use a concentration of 0.25 - 2 µg/ml.|
|WB||Use a concentration of 0.04 - 0.4 µg/ml.|
FunctionSingle stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.
Tissue specificityPresent in all tissues examined.
Involvement in diseaseDefects in CNBP are the cause of dystrophia myotonica type 2 (DM2) [MIM:602668]; also known as proximal myotonic myopathy (PROMM). A multisystem disease characterized by the association of proximal muscle weakness with myotonia, cardiac manifestations and cataract. Additional features can include hyperhidrosis, testicular atrophy, insulin resistance and diabetes and central nervous system anomalies in rare cases. Note=The causative mutation is a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene.
Sequence similaritiesContains 7 CCHC-type zinc fingers.
Cellular localizationCytoplasm. Endoplasmic reticulum.
- Information by UniProt
- CCHC type zinc finger nucleic acid binding protein antibody
- Cellular nucleic acid binding protein antibody
- Cellular nucleic acid-binding protein antibody
All lanes : Anti-CNBP antibody (ab272676) at 0.4 µg/ml
Lane 1 : RT4 cells (Human urinary bladder cancer cell line)
Lane 2 : U-251 MG cells (Human brain glioma cell line)
Lane 3 : Human plasma
Lane 4 : Human liver tissue
Lane 5 : Human tonsil tissue
PFA fixed, Triton X-100 permeablized SH-SY5Y cells (human neuroblastoma cell line from bone marrow) labeling CNBP (green) using ab272676 at 2 ug/ml in ICC/IF analysis.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab272676 has not yet been referenced specifically in any publications.