Overview

  • Product name

  • Description

    Rabbit polyclonal to CNG3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ELISA, WBmore details
  • Species reactivity

    Reacts with: Recombinant fragment
    Predicted to work with: Chicken
  • Immunogen

    Synthetic peptide:

    TNKKAVDEREVLKYLPDKL

    , corresponding to internal sequence amino acids 395-413 of Chicken CNG3

Properties

Applications

Our Abpromise guarantee covers the use of ab58716 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 75 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.

Target

  • Function

    Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
  • Tissue specificity

    Prominently expressed in retina.
  • Involvement in disease

    Defects in CNGA3 are the cause of achromatopsia type 2 (ACHM2) [MIM:216900]; also known as total colorblindness or rod monochromacy (RMCH2). ACHM2 is an autosomal recessive condition characterized by day blindness and photophobia. In ACHM2 patients the cones are defective and the subjects see better at night.
  • Sequence similarities

    Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA3 subfamily.
    Contains 1 cyclic nucleotide-binding domain.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • ACHM2 antibody
    • CCNC1 antibody
    • CCNCa antibody
    • CCNCalpha antibody
    • CNCG3 antibody
    • CNG 3 antibody
    • CNG channel alpha 3 antibody
    • CNG channel alpha-3 antibody
    • CNG-3 antibody
    • CNG3 antibody
    • CNGA3 antibody
    • Cnga3 cyclic nucleotide gated channel alpha 3 antibody
    • CNGA3_HUMAN antibody
    • Cone photoreceptor cGMP gated channel antibody
    • Cone photoreceptor cGMP gated channel alpha subunit antibody
    • Cone photoreceptor cGMP gated channel subunit alpha antibody
    • Cone photoreceptor cGMP-gated channel subunit alpha antibody
    • Cyclic nucleotide gated cation channel alpha 3 antibody
    • Cyclic nucleotide gated channel alpha 3 antibody
    • Cyclic nucleotide gated channel olfactory 3 antibody
    • Cyclic nucleotide gated channel rod photoreceptor subunit alpha antibody
    • Cyclic nucleotide-gated cation channel alpha-3 antibody
    • Cyclic nucleotide-gated channel alpha-3 antibody
    • OTTHUMP00000161120 antibody
    see all

References

This product has been referenced in:

  • Korenbrot JI  et al. EML1 (CNG-modulin) controls light sensitivity in darkness and under continuous illumination in zebrafish retinal cone photoreceptors. J Neurosci 33:17763-76 (2013). Zebrafish . Read more (PubMed: 24198367) »
See 1 Publication for this product

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