Key features and details
- Rabbit polyclonal to CNGA1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-CNGA1 antibody
See all CNGA1 primary antibodies
DescriptionRabbit polyclonal to CNGA1
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Synthetic peptide corresponding to Human CNGA1 (internal sequence).
- WB: HepG2 cell lysate.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.88% Sodium chloride
PBS is without Mg2+ and Ca2+
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab136123 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 79 kDa.|
FunctionVisual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
Tissue specificityRod cells in the retina.
Involvement in diseaseDefects in CNGA1 are the cause of retinitis pigmentosa type 49 (RP49) [MIM:613756]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Sequence similaritiesBelongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily.
Contains 1 cyclic nucleotide-binding domain.
- Information by UniProt
- cGMP gated cation channel alpha 1 antibody
- cGMP-gated cation channel alpha-1 antibody
- CNCG antibody
ab136123 has not yet been referenced specifically in any publications.