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    cnnm1-antibody-ab122648.pdf

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Cell Biology Cell Cycle Cyclins Other Cyclins
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Anti-CNNM1 antibody (ab122648)

  • Datasheet
Submit a review Submit a question References (1)

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Immunocytochemistry/ Immunofluorescence - Anti-CNNM1 antibody (ab122648)
  • Western blot - Anti-CNNM1 antibody (ab122648)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CNNM1 antibody (ab122648)

Key features and details

  • Rabbit polyclonal to CNNM1
  • Suitable for: ICC/IF, WB, IHC-P
  • Reacts with: Human
  • Isotype: IgG

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Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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Overview

  • Product name

    Anti-CNNM1 antibody
  • Description

    Rabbit polyclonal to CNNM1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    antigen sequence:TACHMDSSPQSPDMEAFTDGDSTKAPTTRGTPQTPKDDPAI TLLNNRNSLPCSRSDGLRS PSEVVYLRMEELAFTQEEMTDFEEHSTQQLT, corresponding to amino acids 791-881 of Human CNNM1 Isoform 1 (Q9NRU3).

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control

    • Human testis tissue Human plasma tissue Human liver tissue lysate Human tonsil tissue lysate RT 4 cell line lysate U 251 MG cell line lysate
  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -20ºC.
  • Storage buffer

    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Cell Biology
    • Cell Cycle
    • Cyclins
    • Other Cyclins
    • Epigenetics and Nuclear Signaling
    • Cell cycle
    • Cyclins
    • Other Cyclins

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Applications

Our Abpromise guarantee covers the use of ab122648 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

WB 1/250 - 1/500.
IHC-P 1/1000 - 1/2500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Probable metal transporter.
  • Tissue specificity

    Restricted to brain and testis.
  • Sequence similarities

    Belongs to the ACDP family.
    Contains 2 CBS domains.
  • Cellular localization

    Cell membrane.
  • Target information above from: UniProt accession Q9NRU3 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 26507 Human
    • Omim: 607802 Human
    • SwissProt: Q9NRU3 Human
    • Unigene: 274579 Human
    • Alternative names

      • ACDP1 antibody
      • Ancient conserved domain protein 1 antibody
      • Ancient conserved domain-containing protein 1 antibody
      • CNNM1 antibody
      • CNNM1_HUMAN antibody
      • Cyclin-M1 antibody
      • FLJ31632 antibody
      • Metal transporter CNNM1 antibody
      • OTTHUMP00000020253 antibody
      see all

    Images

    • Immunocytochemistry/ Immunofluorescence - Anti-CNNM1 antibody (ab122648)
      Immunocytochemistry/ Immunofluorescence - Anti-CNNM1 antibody (ab122648)
      Immunofluorescent staining of Human cell line A-431 shows positivity in nucleus but not nucleoli, plasma membrane and cytoplasm. Recommended concentration of ab122648 1-4 µg/ml. Cells treated with PFA/Triton X-100.
    • Western blot - Anti-CNNM1 antibody (ab122648)
      Western blot - Anti-CNNM1 antibody (ab122648)
      All lanes : Anti-CNNM1 antibody (ab122648) at 1/250 dilution

      Lane 1 : RT 4 cell line lysate
      Lane 2 : U 251 MG cell line lysate
      Lane 3 : Human plasma
      Lane 4 : Human liver tissue lysate
      Lane 5 : Human tonsil tissue lysate
    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CNNM1 antibody (ab122648)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CNNM1 antibody (ab122648)
      ab122648, at 1/1000, staining CNNM1 in paraffin embedded Human testis by Immunohistochemistry.

    Protocols

    • Immunohistochemistry protocols
    • Immunocytochemistry & immunofluorescence protocols
    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (1)

    Publishing research using ab122648? Please let us know so that we can cite the reference in this datasheet.

    ab122648 has been referenced in 1 publication.

    • Xie Y  et al. SNHG7 Facilitates Hepatocellular Carcinoma Occurrence by Sequestering miR-9-5p to Upregulate CNNM1 Expression. Cancer Biother Radiopharm N/A:N/A (2020). PubMed: 32397799

    Customer reviews and Q&As

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