Product nameCNQX disodium salt (mM/ml), AMPA / kainate antagonist (water soluble)
DescriptionAMPA / kainate antagonist (water soluble). 1 ml water soluble pack.
Water soluble, potent, competitive AMPA / kainate receptor antagonist. Also antagonist at NMDA receptor glycine site.
Soluble in 1 ml water to give specified mM/ml concentration. Find out more.
Chemical name1,2,3,4-Tetrahydro-7-nitro-2,3-dioxoquinoxaline-6-carbonitrile disodium
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in 1 ml of water to give specified mM/ml concentration
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144488 has been referenced in 7 publications.
- Ul Haq R et al. Adrenergic modulation of sharp wave-ripple activity in rat hippocampal slices. Hippocampus 22:516-33 (2012). PubMed: 21254303
- Jo YH et al. Cross-talk between P2X4 and gamma-aminobutyric acid, type A receptors determines synaptic efficacy at a central synapse. J Biol Chem 286:19993-20004 (2011). PubMed: 21482824
- Liotta A et al. Partial disinhibition is required for transition of stimulus-induced sharp wave-ripple complexes into recurrent epileptiform discharges in rat hippocampal slices. J Neurophysiol 105:172-87 (2011). PubMed: 20881199
- Klyuch BP et al. The dynamics of single spike-evoked adenosine release in the cerebellum. J Physiol 589:283-95 (2011). PubMed: 21078589
- Tinnes S et al. Epileptiform activity interferes with proteolytic processing of Reelin required for dentate granule cell positioning. FASEB J 25:1002-13 (2011). PubMed: 21148112
- Connelly WM & Lees G Modulation and function of the autaptic connections of layer V fast spiking interneurons in the rat neocortex. J Physiol 588:2047-63 (2010). PubMed: 20351046
- Kellett DO et al. Memory consolidation in the cerebellar cortex. PLoS One 5:e11737 (2010). PubMed: 20686596