CNQX disodium salt (mM/ml), AMPA / kainate antagonist (water soluble) (ab144488)

Overview

  • Product name

    CNQX disodium salt (mM/ml), AMPA / kainate antagonist (water soluble)
  • Description

    AMPA / kainate antagonist (water soluble). 1 ml water soluble pack.
  • Biological description

    Water soluble, potent, competitive AMPA / kainate receptor antagonist. Also antagonist at NMDA receptor glycine site.

    Soluble in 1 ml water to give specified mM/ml concentration. Find out more.
  • Purity

    > 99%
  • CAS Number

    479347-85-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1,2,3,4-Tetrahydro-7-nitro-2,3-dioxoquinoxaline-6-carbonitrile disodium
  • Molecular weight

    276.12
  • Molecular formula

    C9H2N4Na2O4
  • PubChem identifier

    2821
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in 1 ml of water to give specified mM/ml concentration
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    [Na+].[Na+].[O-][N+](=O)c1cc2nc([O-])c([O-])nc2cc1C#N
  • Source

    Synthetic

  • Research areas

Images

  • Effects of cortical and nuclear CNQX on performance of established CRs.

    Mean (±1 SEM) effects of  CNQX (6 nmol) on CR performance when infused into cortical (2 µl; top panels) or nuclear cannulae (1 µl; bottom panels).

    (From Figure 4 of Kellett et al).

References

This product has been referenced in:

  • Long SK  et al. Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate- and quisqualate-mediated depolarization of rat motoneurones in vitro. Br J Pharmacol 100:850-4 (1990). Read more (PubMed: 1976402) »
  • Honoré T  et al. Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241:701-3 (1988). Read more (PubMed: 2899909) »
  • Birch PJ  et al. 6,7-Dinitro-quinoxaline-2,3-dion and 6-nitro,7-cyano-quinoxaline-2,3-dion antagonise responses to NMDA in the rat spinal cord via an action at the strychnine-insensitive glycine receptor. Eur J Pharmacol 156:177-80 (1988). Read more (PubMed: 2905271) »
See all 7 Publications for this product

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