Overview

  • Product name

  • Description

    Rabbit polyclonal to CNTFR
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human CNTFR aa 119-123 conjugated to keyhole limpet haemocyanin.
    Sequence:

    NTYPK

  • Positive control

    • Rat brain tissue and Hela cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab127425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 41 kDa.

Target

  • Function

    Binds to CNTF. The alpha subunit provides the receptor specificity.
  • Tissue specificity

    Nervous system and skeletal muscle.
  • Sequence similarities

    Belongs to the type I cytokine receptor family. Type 3 subfamily.
    Contains 2 fibronectin type-III domains.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Domain

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Ciliary neurotrophic factor receptor alpha antibody
    • Ciliary neurotrophic factor receptor antibody
    • Ciliary neurotrophic factor receptor subunit alpha antibody
    • CNTF Receptor alpha antibody
    • CNTF receptor subunit alpha antibody
    • CNTFR Alpha antibody
    • CNTFR antibody
    • CNTFR-alpha antibody
    • CNTFR_HUMAN antibody
    see all

Images

  • All lanes : Anti-CNTFR antibody (ab127425)

    Lane 1 : Rat brain lysate
    Lane 2 : Hela whole cell lysate

    Performed under reducing conditions.

References

This product has been referenced in:

  • Severi I  et al. Opposite effects of a high-fat diet and calorie restriction on ciliary neurotrophic factor signaling in the mouse hypothalamus. Front Neurosci 7:263 (2013). Read more (PubMed: 24409114) »
See 1 Publication for this product

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