COG 133, apolipoprotein peptide fragment (ab269699)
Overview
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Product name
COG 133, apolipoprotein peptide fragment -
Description
ApoE peptide mimetic. -
Biological description
ApoE peptide mimetic. Corresponds to amino acids 133-149 of human ApoE. Non-cometitive alpha-7 nicotinic acetylcholine receptor antagonist (IC50 = 445 nM). Inhibits NMDA receptor channel function via interaction with the low-density lipoprotein receptor-related protein. Reduces inflammation, demyleination and cellular infiltration in animal models of multiple sclerosis. Reduces markers of inflammation in 5-fluorouracil model of intestinal mucositis.
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CAS Number
514200-66-9 -
Chemical structure
Properties
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Molecular weight
2169.73 -
Molecular formula
C97H181N37O19 -
Sequence
LRVRLASHLRKLRKRLL -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References
ab269699 has not yet been referenced specifically in any publications.
