Overview

  • Product name

  • Description

    Goat polyclonal to COG8/DOR1
  • Host species

    Goat
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Monkey
  • Immunogen

    Synthetic peptide corresponding to Human COG8/DOR1 aa 381-393 (internal sequence) (Cysteine residue). NP_115758.3
    Sequence:

    C-KAIQETVEKFQEE


    Database link: Q96MW5

  • Positive control

    • IHC-P: Human kidney tissue.
  • General notes

     This product was previously labelled as COG8

     

Properties

Applications

Our Abpromise guarantee covers the use of ab227887 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Relevance

    COG8 is a component of the conserved oligomeric Golgi (COG) complex. This is a multiprotein complex that plays a structural role in the Golgi apparatus and is involved in intracellular membrane trafficking and glycoprotein modification. Mutations in this gene cause congenital disorder of glycosylation, type IIh, a disease that is characterized by under-glycosylated serum proteins and whose symptoms include severe psychomotor retardation, failure to thrive, seizures and dairy and wheat product intolerance. It is required for normal Golgi function.
  • Cellular localization

    Golgi apparatus; Peripheral membrane protein.
  • Database links

  • Alternative names

    • COG complex subunit 8 antibody
    • Component of oligomeric golgi complex 8 antibody
    • Conserved oligomeric Golgi complex component 8 dependent on RIC1 antibody
    • DOR1 antibody

Images

  • Formalin-fixed, paraffin-embedded human kidney tissue stained for COG8/DOR1 using ab227887 at 5 µg/ml in immunohistochemical analysis.

References

ab227887 has not yet been referenced specifically in any publications.

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