Anti-COLEC11 antibody (ab238585)
Key features and details
- Rabbit polyclonal to COLEC11
- Suitable for: IHC-P, WB
- Reacts with: Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-COLEC11 antibody
See all COLEC11 primary antibodies -
Description
Rabbit polyclonal to COLEC11 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Rat, Human -
Immunogen
Recombinant fragment corresponding to Human COLEC11 aa 26-271.
Database link: Q9BWP8 -
Positive control
- IHC-P: Human kidney tissue. WB: Rat liver tissue lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab238585 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/20 - 1/200.
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WB |
Use a concentration of 4 µg/ml. Predicted molecular weight: 29 kDa.
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Notes |
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IHC-P
1/20 - 1/200. |
WB
Use a concentration of 4 µg/ml. Predicted molecular weight: 29 kDa. |
Target
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Function
Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N-acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration. -
Tissue specificity
Ubiquitous. -
Involvement in disease
Defects in COLEC11 are the cause of 3MC syndrome type 2 (3MC2) [MIM:265050]. 3MC2 is an a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly archedDE eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes. -
Sequence similarities
Belongs to the COLEC10/COLEC11 family.
Contains 1 C-type lectin domain.
Contains 1 collagen-like domain. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 78989 Human
- Entrez Gene: 366588 Rat
- Omim: 612502 Human
- SwissProt: Q9BWP8 Human
- Unigene: 32603 Human
- Unigene: 735715 Human
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Alternative names
- CL K1 antibody
- CL K1 I antibody
- CL K1 II antibody
see all
Images
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All lanes: ab238585 antibody at 4μg/ml + Rat liver tissue.
Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution.
Predicted band size: 29, 27, 22, 30, 25, 24, 31 kDa.
Observed band size: 29 kDa. -
Paraffin-embedded human kidney tissue stained for COLEC11 with ab238585 at a 1/100 dilution in immunohistochemical analysis.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab238585 has not yet been referenced specifically in any publications.