Key features and details
- Rabbit polyclonal to Collagen I + II + III + IV + V
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Collagen I + II + III + IV + V antibody
See all Collagen I + II + III + IV + V primary antibodies
DescriptionRabbit polyclonal to Collagen I + II + III + IV + V
Species reactivityReacts with: Human
Full length native Collagen I + II + III + IV + V proteins (purified) from human placenta.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.50
Constituents: 0.1% Dextran, 0.87% Sodium chloride, 0.164% Sodium phosphate, 0.1% Mannitol
Concentration information loading...
PurityImmunogen affinity purified
Purification notesThis antibody is affinity isolated. It was purified by affinity chromatography on immobilized Collagen types I-V.
FunctionType I collagen is a member of group I collagen (fibrillar forming collagen).
Tissue specificityForms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.
Involvement in diseaseCaffey disease
Ehlers-Danlos syndrome, classic type
Ehlers-Danlos syndrome 7A
Osteogenesis imperfecta 1
Osteogenesis imperfecta 2
Osteogenesis imperfecta 3
Osteogenesis imperfecta 4
A chromosomal aberration involving COL1A1 is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGF.
Sequence similaritiesBelongs to the fibrillar collagen family.
Contains 1 fibrillar collagen NC1 domain.
Contains 1 VWFC domain.
DomainThe C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
modificationsProline residues at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Proline residues at the second position of the tripeptide repeating unit (G-P-X) are hydroxylated in some of the chains.
O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
Cellular localizationSecreted, extracellular space, extracellular matrix.
- Information by UniProt
- Alpha-1 type I collagen antibody
- CO1A1_HUMAN antibody
- COL1A1 antibody
ab36064 has been referenced in 3 publications.
- Luong B et al. The vacuolar-type ATPase inhibitor archazolid increases tumor cell adhesion to endothelial cells by accumulating extracellular collagen. PLoS One 13:e0203053 (2018). PubMed: 30204757
- Schwenk R et al. The pretubulysin-induced exposure of collagen is caused by endothelial cell retraction that results in an increased adhesion and decreased transmigration of tumor cells. Oncotarget 8:77622-77633 (2017). PubMed: 29100413
- Sur S et al. Synergistic regulation of cerebellar Purkinje neuron development by laminin epitopes and collagen on an artificial hybrid matrix construct. Biomater Sci 2:903-914 (2014). PubMed: 25530849