Overview

  • Product name

    Anti-Collagen I + Collagen III antibody
    See all Collagen I + Collagen III primary antibodies
  • Description

    Rabbit polyclonal to Collagen I + Collagen III
  • Host species

    Rabbit
  • Specificity

    This antibody showa cross reactivity with: Bovine collagen type III 100%; Bovine collagen type I 100%; Bovine collagen type II <3%; Bovine collagen type IV <1%; Bovine collagen type V <1%; Bovine fibronectin and albumin <0.5%; and Bovine immunoglobulin <0.5%.
  • Tested applications

    Suitable for: ELISA, ICC/IFmore details
  • Species reactivity

    Reacts with: Cow
  • Immunogen

    Full length native Collagen I + Collagen III proteins (purified) from cow skin.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    pH: 7.50
    Constituents: 0.58% Sodium chloride, 0.164% Sodium phosphate, 0.381% Sodium borate, 0.1% Mannitol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    This antibody was affinity isolated. It was purified by affinity chromatography on immobilized Collagen I + III.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab36074 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/2000 - 1/8000.
ICC/IF 1/10 - 1/40.

Target

  • Relevance

    Collagen I is a fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. Collagen III is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with Collagen I. Mutations in this gene are associated with Ehlers Danlos syndrome type IV, and with aortic and arterial aneurysms. Although alternate transcripts have been detected for this gene, they are the result of mutations; these mutations alter splicing, often leading to the exclusion of multiple exons.
  • Cellular localization

    Secreted
  • Database links

  • Alternative names

    • Alpha 1 type I collagen antibody
    • Alpha 2 type I collagen antibody
    • COL1A1 antibody
    • COL1A2 antibody
    • COL3A1 antibody
    • Collagen fetal antibody
    • Collagen type I alpha 1 antibody
    • Collagen type I alpha 2 antibody
    • Collagen type III alpha 1 antibody
    • OI4 antibody
    • Type I collagen alpha 1 chain antibody
    • Type I procollagen antibody
    see all

References

ab36074 has not yet been referenced specifically in any publications.

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