Overview

  • Product name
    Anti-Collagen VI antibody [EPR7888(N)]
    See all Collagen VI primary antibodies
  • Description
    Rabbit monoclonal [EPR7888(N)] to Collagen VI
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: ICC/IF,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human Collagen VI aa 200-300. The exact sequence is proprietary.
    Database link: P12110

  • Positive control
    • Human skin, placenta and fetal heart lysates.
  • General notes

    A trial size is available to purchase for this antibody.

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab172606 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 140 kDa (predicted molecular weight: 109 kDa).
  • Application notes
    Is unsuitable for ICC/IF,IHC-P or IP.
  • Target

    • Function
      Collagen VI acts as a cell-binding protein.
    • Involvement in disease
      Defects in COL6A1 are a cause of Bethlem myopathy (BM) [MIM:158810]. BM is a rare autosomal dominant proximal myopathy characterized by early childhood onset (complete penetrance by the age of 5) and joint contractures most frequently affecting the elbows and ankles.
      Defects in COL6A1 are a cause of Ullrich congenital muscular dystrophy (UCMD) [MIM:254090]; also known as Ullrich scleroatonic muscular dystrophy. UCMD is an autosomal recessive congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy.
    • Sequence similarities
      Belongs to the type VI collagen family.
      Contains 3 VWFA domains.
    • Post-translational
      modifications
      Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
    • Cellular localization
      Secreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • Database links
    • Alternative names
      • Alpha 1 (VI) chain (61 AA) antibody
      • CO6A1_HUMAN antibody
      • COL6A1 antibody
      • COL6A2 antibody
      • COL6A3 antibody
      • Collagen alpha 2(VI) chain antibody
      • Collagen alpha 3(VI) chain antibody
      • Collagen alpha-1(VI) chain antibody
      • Collagen type VI alpha 1 antibody
      • Collagen type VI alpha 2 antibody
      • Collagen type VI alpha 3 antibody
      • Collagen VI alpha 1 polypeptide antibody
      • Collagen VI alpha 2 polypeptide antibody
      • Collagen VI alpha 3 polypeptide antibody
      • CollagenVI antibody
      • Human mRNA for collagen VI alpha 2 C terminal globular domain antibody
      • OPLL antibody
      • PP3610 antibody
      see all

    Images

    • All lanes : Anti-Collagen VI antibody [EPR7888(N)] (ab172606) at 1/1000 dilution

      Lane 1 : Human skin lysate
      Lane 2 : Human placenta lysate
      Lane 3 : Human fetal heart lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 109 kDa

    References

    This product has been referenced in:
    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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