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Signal Transduction Cytoskeleton / ECM Extracellular Matrix ECM Proteins Collagen
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RecombinantRabMAb

Recombinant Anti-Collagen VI antibody [EPR7888(N)] (ab172606)

  • Datasheet
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Western blot - Anti-Collagen VI antibody [EPR7888(N)] (ab172606)
  • Anti-Collagen VI antibody [EPR7888(N)] (ab172606)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR7888(N)] to Collagen VI
  • Suitable for: WB
  • Reacts with: Human

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Overview

  • Product name

    Anti-Collagen VI antibody [EPR7888(N)]
    See all Collagen VI primary antibodies
  • Description

    Rabbit monoclonal [EPR7888(N)] to Collagen VI
  • Host species

    Rabbit
  • Tested Applications & Species

    Application Species
    WB
    Human
    See all applications and species data
  • Immunogen

    Synthetic peptide within Human Collagen VI aa 200-300. The exact sequence is proprietary.
    Database link: P12110

  • Positive control

    • Human skin, placenta and fetal heart lysates.
  • General notes

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant
  • Concentration information loading...
  • Purity

    Tissue culture supernatant
  • Clonality

    Monoclonal
  • Clone number

    EPR7888(N)
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Cytoskeleton / ECM
    • Extracellular Matrix
    • ECM Proteins
    • Collagen
    • Cancer
    • Invasion/microenvironment
    • ECM
    • Extracellular matrix
    • Other

Associated products

  • Alternative Versions

    • Anti-Collagen VI antibody [EPR7888(N)] - BSA and Azide free (ab249703)
  • Isotype control

    • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)
  • Related Products

    • Native Human Collagen VI protein (ab7538)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab172606 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
ICC
Human
IHC-P
Mouse
WB
Human
All applications
Mouse
Rat
Application Abreviews Notes
WB
1/1000 - 1/10000. Detects a band of approximately 140 kDa (predicted molecular weight: 109 kDa).
Notes
WB
1/1000 - 1/10000. Detects a band of approximately 140 kDa (predicted molecular weight: 109 kDa).
  • Application notes
    Is unsuitable for ICC/IF,IHC-P or IP.
  • Target

    • Function

      Collagen VI acts as a cell-binding protein.
    • Involvement in disease

      Defects in COL6A1 are a cause of Bethlem myopathy (BM) [MIM:158810]. BM is a rare autosomal dominant proximal myopathy characterized by early childhood onset (complete penetrance by the age of 5) and joint contractures most frequently affecting the elbows and ankles.
      Defects in COL6A1 are a cause of Ullrich congenital muscular dystrophy (UCMD) [MIM:254090]; also known as Ullrich scleroatonic muscular dystrophy. UCMD is an autosomal recessive congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy.
    • Sequence similarities

      Belongs to the type VI collagen family.
      Contains 3 VWFA domains.
    • Post-translational
      modifications

      Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
    • Cellular localization

      Secreted > extracellular space > extracellular matrix.
    • Target information above from: UniProt accession P12109 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 1291 Human
      • Entrez Gene: 1292 Human
      • Entrez Gene: 1293 Human
      • Entrez Gene: 12833 Mouse
      • Entrez Gene: 12834 Mouse
      • Entrez Gene: 12835 Mouse
      • Entrez Gene: 294337 Rat
      • Entrez Gene: 361821 Rat
      • Omim: 120220 Human
      • Omim: 120240 Human
      • Omim: 120250 Human
      • SwissProt: P12109 Human
      • SwissProt: P12110 Human
      • SwissProt: P12111 Human
      • SwissProt: Q02788 Mouse
      • SwissProt: Q04857 Mouse
      • Unigene: 474053 Human
      • Unigene: 2509 Mouse
      • Unigene: 232118 Rat
      see all
    • Alternative names

      • Alpha 1 (VI) chain (61 AA) antibody
      • CO6A1_HUMAN antibody
      • COL6A1 antibody
      • COL6A2 antibody
      • COL6A3 antibody
      • collagen 6 antibody
      • Collagen alpha 2(VI) chain antibody
      • Collagen alpha 3(VI) chain antibody
      • Collagen alpha-1(VI) chain antibody
      • collagen six antibody
      • Collagen type VI alpha 1 antibody
      • Collagen type VI alpha 2 antibody
      • Collagen type VI alpha 3 antibody
      • Collagen VI alpha 1 polypeptide antibody
      • Collagen VI alpha 2 polypeptide antibody
      • Collagen VI alpha 3 polypeptide antibody
      • CollagenVI antibody
      • Human mRNA for collagen VI alpha 2 C terminal globular domain antibody
      • OPLL antibody
      • PP3610 antibody
      see all

    Images

    • Western blot - Anti-Collagen VI antibody [EPR7888(N)] (ab172606)
      Western blot - Anti-Collagen VI antibody [EPR7888(N)] (ab172606)
      All lanes : Anti-Collagen VI antibody [EPR7888(N)] (ab172606) at 1/1000 dilution

      Lane 1 : Human skin lysate
      Lane 2 : Human placenta lysate
      Lane 3 : Human fetal heart lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 109 kDa

    • Anti-Collagen VI antibody [EPR7888(N)] (ab172606)
      Anti-Collagen VI antibody [EPR7888(N)] (ab172606)

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (2)

    Publishing research using ab172606? Please let us know so that we can cite the reference in this datasheet.

    ab172606 has been referenced in 2 publications.

    • Endicott J  et al. Authentication of collagen VI antibodies. BMC Res Notes 10:358 (2017). PubMed: 28755659
    • Safaee H  et al. Tethered Jagged-1 Synergizes with Culture Substrate Stiffness to Modulate Notch-Induced Myogenic Progenitor Differentiation. Cell Mol Bioeng 10:501-513 (2017). PubMed: 31719873

    Customer reviews and Q&As

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