Overview

  • Product name

    Anti-Complement C7 antibody
  • Description

    Rabbit polyclonal to Complement C7
  • Host species

    Rabbit
  • Specificity

    ab192346 detects endogenous levels of Complement C7 protein.
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
    Predicted to work with: Orangutan
  • Immunogen

    Recombinant full length protein corresponding to Human Complement C7 aa 1-843.
    Sequence:

    MKVISLFILVGFIGEFQSFSSASSPVNCQWDFYAPWSECNGCTKTQTRRR SVAVYGQYGG QPCVGNAFETQSCEPTRGCPTEEGCGERFRCFSGQCIS KSLVCNGDSDCDEDSADEDRCE DSERRPSCDIDKPPPNIELTGNGYNE LTGQFRNRVINTKSFGGQCRKVFSGDGKDFYRLS GNVLSYTFQVKINN DFNYEFYNSTWSYVKHTSTEHTSSSRKRSFFRSSSSSSRSYTSHTN EI HKGKSYQLLVVENTVEVAQFINNNPEFLQLAEPFWKELSHLPSLYDYSAY RRLIDQYG THYLQSGSLGGEYRVLFYVDSEKLKQNDFNSVEEKKCKSS GWHFVVKFSSHGCKELENAL KAASGTQNNVLRGEPFIRGGGAGFISGL SYLELDNPAGNKRRYSAWAESVTNLPQVIKQK LTPLYELVKEVPCASV KKLYLKWALEEYLDEFDPCHCRPCQNGGLATVEGTHCLCHCKPY TFGA ACEQGVLVGNQAGGVDGGWSCWSSWSPCVQGKKTRSRECNNPPPSGGGRS CVGETT ESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFV QDEGTMFPVGKNVVYTCN EGYSLIGNPVARCGEDLRWLVGEMHCQKIA CVLPVLMDGIQSHPQKPFYTVGEKVTVSCS GGMSLEGPSAFLCGSSLK WSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYE CGPSLD VCAQDERSKRILPLTVCKMHVLHCQGRNYTLTGRDSCTLPASAEKACGAC PLWG KCDAESSKCVCREASECEEEGFSICVEVNGKEQTMSECEAGALR CRGQSISVTSIRPCAA ETQ


    Database link: P10643

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.1% Sodium azide
    Constituents: 49% PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    Purity is > 95% (by SDS-PAGE).
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab192346 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 94 kDa.

Target

  • Function

    Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.
  • Involvement in disease

    Defects in C7 are a cause of complement component 7 deficiency (C7D) [MIM:610102]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
  • Sequence similarities

    Belongs to the complement C6/C7/C8/C9 family.
    Contains 1 EGF-like domain.
    Contains 1 LDL-receptor class A domain.
    Contains 1 MACPF domain.
    Contains 2 Sushi (CCP/SCR) domains.
    Contains 2 TSP type-1 domains.
  • Post-translational
    modifications

    C7 has 28 disulfide bridges.
    O- and C-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • C7 antibody
    • CO7_HUMAN antibody
    • Complement component C7 antibody

References

ab192346 has not yet been referenced specifically in any publications.

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