Key features and details
- Rabbit polyclonal to Complement C8
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
Product nameAnti-Complement C8 antibody
See all Complement C8 primary antibodies
DescriptionRabbit polyclonal to Complement C8
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse
Recombinant fragment (His-T7-tag) corresponding to Mouse Complement C8 aa 21-300. (Expressed in E.coli).
QEKVNQRVTRAVTPQAVSCQLSDWYKWTDCFPCQDKKYRYRSLLQPSKFG GTICSGDIWDEASCDSPTPCLRQAQCGQDFQCRETGRCLKRHLVCNGDND CLDGSDESDCEDVRVTEDDCHQYEPIPGSERAALGYNILTQEEAQSVYDA KYYGGQCETVYNGDWRKLRYDPTCERLYYGEDEKYFRKPYNFLKYHFEAL ADTSISSEFYDDANDLFFHIKNGKSHSAGVTVGVAPVKSPVSIEVTGSGS KASSFLNKLNKYNEKRYGFMRVSTKIQTAQ
Database link: Q8K182
- WB: Mouse liver lysate; Recombinant mouse Complement C8 protein.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab231255 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Our Abpromise guarantee covers the use of ab231255 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.2 - 2 µg/ml. Predicted molecular weight: 66 kDa.|
FunctionConstituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.
Involvement in diseaseDefects in C8A are a cause of complement component 8 deficiency type 1 (C8D1) [MIM:613790]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
Sequence similaritiesBelongs to the complement C6/C7/C8/C9 family.
Contains 1 EGF-like domain.
Contains 1 LDL-receptor class A domain.
Contains 1 MACPF domain.
Contains 2 TSP type-1 domains.
Cellular localizationSecreted. Cell membrane. Secreted as soluble protein. Inserts into the cell membrane of target cells.
- Information by UniProt
- C8A antibody
- CO8A_HUMAN antibody
- Complement component 8 subunit alpha antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab231255 has not yet been referenced specifically in any publications.