Key features and details
- Mouse monoclonal [M13/12] to Complement factor B
- Reacts with: Human
- Isotype: IgG1
Product nameAnti-Complement factor B antibody [M13/12]
See all Complement factor B primary antibodies
DescriptionMouse monoclonal [M13/12] to Complement factor B
Specificityab106139 recognizes complement factor B/Bb
Species reactivityReacts with: Human
Complement factor B/Bb
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.02% Sodium azide
Constituents: 0.1% BSA, PBS
Concentration information loading...
PurityProtein G purified
RelevanceFactor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
Cellular localizationPlasma membrane and Secreted
- C3/C5 convertase antibody
- Complement factor B antibody
- Glycine-rich beta glycoprotein antibody
ab106139 has been referenced in 2 publications.
- Oppermann M et al. Elevated plasma levels of the immunosuppressive complement fragment Ba in renal failure. Kidney Int 40:939-47 (1991). PubMed: 1837062
- Oppermann M et al. Quantitation of components of the alternative pathway of complement (APC) by enzyme-linked immunosorbent assays. J Immunol Methods 133:181-90 (1990). PubMed: 2146321