Complex I Enzyme Activity Microplate Assay Kit (Colorimetric) (ab109721)

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ab109721 has been referenced in 74 publications.

  • Zhang XL  et al. RNAi-mediated knockdown of DJ-1 leads to mitochondrial dysfunction via Akt/GSK-3ß and JNK signaling pathways in dopaminergic neuron-like cells. Brain Res Bull N/A:N/A (2019). PubMed: 30634017
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  • Venkatesh S  et al. Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo. J Mol Cell Cardiol 128:38-50 (2019). PubMed: 30625302
  • Huang Q  et al. LYRM2 directly regulates complex I activity to support tumor growth in colorectal cancer by oxidative phosphorylation. Cancer Lett 455:36-47 (2019). PubMed: 31004700
  • Hirpara J  et al. Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance. Redox Biol N/A:101076 (2018). PubMed: 30642723
  • Lee SY & Long F Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation. J Clin Invest 128:5573-5586 (2018). PubMed: 30284985
  • Yagil C  et al. A novel mutation in the NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4 (Ndufa4) gene links mitochondrial dysfunction to the development of diabetes in a rodent model. Dis Model Mech 11:N/A (2018). PubMed: 30361421
  • Jing R  et al. A Screen Using iPSC-Derived Hepatocytes Reveals NAD+ as a Potential Treatment for mtDNA Depletion Syndrome. Cell Rep 25:1469-1484.e5 (2018). PubMed: 30404003
  • Matsubara M  et al. Analysis of mitochondrial function in human induced pluripotent stem cells from patients with mitochondrial diabetes due to the A3243G mutation. Sci Rep 8:949 (2018). PubMed: 29343702
  • Zakirova Z  et al. Mutations in THAP1/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions. PLoS Genet 14:e1007169 (2018). PubMed: 29364887
  • Walheim E  et al. Respiromics - An integrative analysis linking mitochondrial bioenergetics to molecular signatures. Mol Metab 9:4-14 (2018). PubMed: 29361498
  • Tetri LH  et al. Sex-Specific Skeletal Muscle Fatigability and Decreased Mitochondrial Oxidative Capacity in Adult Rats Exposed to Postnatal Hyperoxia. Front Physiol 9:326 (2018). PubMed: 29651255
  • Andreux PA  et al. Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly. Sci Rep 8:8548 (2018). PubMed: 29867098
  • Wu YR  et al. Bioactivity and gene expression profiles of hiPSC-generated retinal ganglion cells in MT-ND4 mutated Leber's hereditary optic neuropathy. Exp Cell Res 363:299-309 (2018). PubMed: 29366807
  • Ratcliffe LE  et al. Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons. Neuroscience N/A:N/A (2018). PubMed: 30056117
  • Thakur S  et al. Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer In Vitro and In Vivo. Clin Cancer Res N/A:N/A (2018). PubMed: 29691295
  • Jonikas M  et al. Stem cell modeling of mitochondrial parkinsonism reveals key functions of OPA1. Ann Neurol 83:915-925 (2018). PubMed: 29604226
  • Sun J  et al. Anthocyanins isolated from blueberry ameliorates CCl4 induced liver fibrosis by modulation of oxidative stress, inflammation and stellate cell activation in mice. Food Chem Toxicol 120:491-499 (2018). PubMed: 30056145
  • Akimoto M  et al. Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis. Cell Death Dis 9:804 (2018). PubMed: 30038429
  • Luo X  et al. DNMT1 mediates metabolic reprogramming induced by Epstein-Barr virus latent membrane protein 1 and reversed by grifolin in nasopharyngeal carcinoma. Cell Death Dis 9:619 (2018). PubMed: 29795311
  • Secinaro MA  et al. Glycolysis promotes caspase-3 activation in lipid rafts in T cells. Cell Death Dis 9:62 (2018). PubMed: 29352186
  • Xu S  et al. Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation. Signal Transduct Target Ther 2:16035 (2017). PubMed: 29263907
  • Lin H  et al. Early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in the KIKO mouse model of Friedreich ataxia. Dis Model Mech 10:1343-1352 (2017). PubMed: 29125827
  • Chiu CC  et al. PARK14 PLA2G6 mutants are defective in preventing rotenone-induced mitochondrial dysfunction, ROS generation and activation of mitochondrial apoptotic pathway. Oncotarget 8:79046-79060 (2017). PubMed: 29108286
  • Elkis Y  et al. A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells. Nat Commun 8:940 (2017). PubMed: 29038547
  • Lu YW  et al. Human adenine nucleotide translocases physically and functionally interact with respirasomes. Mol Biol Cell 28:1489-1506 (2017). PubMed: 28404750
  • Tang K  et al. Translocase of Inner Membrane 50 Functions as a Novel Protective Regulator of Pathological Cardiac Hypertrophy. J Am Heart Assoc 6:N/A (2017). PubMed: 28432072
  • Caino MC  et al. Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer. J Clin Invest 127:3755-3769 (2017). PubMed: 28891816
  • Guo NL  et al. Isoflurane promotes glucose metabolism through up-regulation ofmiR-21and suppresses mitochondrial oxidative phosphorylation in ovarian cancer cells. Biosci Rep 37:N/A (2017). PubMed: 28951521
  • Rychtarcikova Z  et al. Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism. Oncotarget 8:6376-6398 (2017). Functional Studies . PubMed: 28031527
  • Zhao H  et al. Peptide SS-31 upregulates frataxin expression and improves the quality of mitochondria: implications in the treatment of Friedreich ataxia. Sci Rep 7:9840 (2017). PubMed: 28852135
  • Vendrov AE  et al. Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice. J Am Heart Assoc 6:N/A (2017). PubMed: 29079564
  • Merz TM  et al. Mitochondrial function of immune cells in septic shock: A prospective observational cohort study. PLoS One 12:e0178946 (2017). Functional Studies . PubMed: 28591158
  • Bartolome F  et al. Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates. Sci Rep 7:1666 (2017). Functional Studies . PubMed: 28490746
  • Sun S  et al. Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming. Cell Death Dis 8:e2870 (2017). PubMed: 28594398
  • Dadson K  et al. The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1a and Pink1. Sci Rep 7:41490 (2017). PubMed: 28148912
  • Zeitlow K  et al. The biological foundation of the genetic association of TOMM40 with late-onset Alzheimer's disease. Biochim Biophys Acta 1863:2973-2986 (2017). PubMed: 28768149
  • Silva Santos LF  et al. Catechin and epicatechin reduce mitochondrial dysfunction and oxidative stress induced by amiodarone in human lung fibroblasts. J Arrhythm 33:220-225 (2017). PubMed: 28607618
  • Diss L  et al. Acute paraquat exposure impairs colonic motility by selectively attenuating nitrergic signalling in the mouse. Auton Neurosci 195:8-15 (2016). PubMed: 26853977
  • Zhang Y  et al. Overexpression of DJ-1/PARK7, the Parkinson's disease-related protein, improves mitochondrial function via Akt phosphorylation on threonine 308 in dopaminergic neuron-like cells. Eur J Neurosci 43:1379-88 (2016). PubMed: 26913805
  • Zhang Y  et al. Protective effects of DJ-1 medicated Akt phosphorylation on mitochondrial function are promoted by Da-Bu-Yin-Wan in 1-methyl-4-phenylpyridinium-treated human neuroblastoma SH-SY5Y cells. J Ethnopharmacol 187:83-93 (2016). PubMed: 27114059
  • Seo JH  et al. The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis. PLoS Biol 14:e1002507 (2016). PubMed: 27389535
  • Xin G  et al. Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release. Sci Rep 6:36222 (2016). PubMed: 27805009
  • Machado AK  et al. Neuroprotective Effects of Açaí (Euterpe oleracea Mart.) against Rotenone In Vitro Exposure. Oxid Med Cell Longev 2016:8940850 (2016). WB . PubMed: 27781077
  • Delgado-Camprubi M  et al. Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation. Cell Death Differ N/A:N/A (2016). PubMed: 27689878
  • Bruns DR  et al. Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction. Am J Physiol Lung Cell Mol Physiol 308:L158-67 (2015). PubMed: 25416385
  • Hao E  et al. Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis. Mol Med 21:38-45 (2015). PubMed: 25569804
  • Yao X  et al. Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model. PLoS One 10:e0139416 (2015). Functional Studies ; Rat . PubMed: 26448624
  • Pertega-Gomes N  et al. A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: a role for monocarboxylate transporters as metabolic targets for therapy. J Pathol 236:517-30 (2015). Functional Studies . PubMed: 25875424
  • Li K  et al. Glutamine Reduces the Apoptosis of H9C2 Cells Treated with High-Glucose and Reperfusion through an Oxidation-Related Mechanism. PLoS One 10:e0132402 (2015). Functional Studies . PubMed: 26146991
  • Chen L  et al. Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis. J Biol Chem 290:28097-106 (2015). PubMed: 26400084
  • Pan H  et al. Mitochondrial modulation by Epigallocatechin 3-Gallate ameliorates cisplatin induced renal injury through decreasing oxidative/nitrative stress, inflammation and NF-kB in mice. PLoS One 10:e0124775 (2015). PubMed: 25875356
  • Zhang P  et al. TRAP1 Provides Protection Against Myocardial Ischemia-Reperfusion Injury by Ameliorating Mitochondrial Dysfunction. Cell Physiol Biochem 36:2072-82 (2015). PubMed: 26202366
  • Im I  et al. Mitochondrial Respiratory Defect Causes Dysfunctional Lactate Turnover via AMP-activated Protein Kinase Activation in Human-induced Pluripotent Stem Cell-derived Hepatocytes. J Biol Chem 290:29493-505 (2015). PubMed: 26491018
  • Li X  et al. Traditional chinese medicine shuang shen ning xin attenuates myocardial ischemia/reperfusion injury by preserving of mitochondrial function. Evid Based Complement Alternat Med 2014:180965 (2014). PubMed: 25031602
  • Tonin Y  et al. Modeling of antigenomic therapy of mitochondrial diseases by mitochondrially addressed RNA targeting a pathogenic point mutation in mitochondrial DNA. J Biol Chem 289:13323-34 (2014). PubMed: 24692550
  • Verbeek J  et al. Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis. Gut N/A:N/A (2014). PubMed: 24917551
  • Alfaradhi MZ  et al. Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity. Am J Physiol Regul Integr Comp Physiol 307:R26-34 (2014). Functional Studies ; Mouse . PubMed: 24789994
  • Subramaniam SR  et al. Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein. Neurobiol Dis 70:204-13 (2014). PubMed: 25016198
  • Tian L  et al. The p38 pathway regulates oxidative stress tolerance by phosphorylation of mitochondrial protein IscU. J Biol Chem 289:31856-65 (2014). PubMed: 25204651
  • Yaffe E  et al. Oncogenic properties of a spermatogenic meiotic variant of fer kinase expressed in somatic cells. Cancer Res 74:6474-85 (2014). PubMed: 25237066
  • Yao X  et al. Estrogen-provided cardiac protection following burn trauma is mediated through a reduction in mitochondria-derived DAMPs. Am J Physiol Heart Circ Physiol 306:H882-94 (2014). Rat . PubMed: 24464748
  • Kim HK  et al. B7-H4 downregulation induces mitochondrial dysfunction and enhances doxorubicin sensitivity via the cAMP/CREB/PGC1-a signaling pathway in HeLa cells. Pflugers Arch 466:2323-38 (2014). PubMed: 24658911
  • Kumarasamy S  et al. Construction of two novel reciprocal conplastic rat strains and characterization of cardiac mitochondria. Am J Physiol Heart Circ Physiol 304:H22-32 (2013). Functional Studies ; Rat . PubMed: 23125210
  • Santidrian AF  et al. Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. J Clin Invest 123:1068-81 (2013). PubMed: 23426180
  • Gu F  et al. Alterations in mitochondrial DNA copy number and the activities of electron transport chain complexes and pyruvate dehydrogenase in the frontal cortex from subjects with autism. Transl Psychiatry 3:e299 (2013). PubMed: 24002085
  • Lopes Costa A  et al. Beneficial effects of resveratrol on respiratory chain defects in patients' fibroblasts involve estrogen receptor and estrogen-related receptor alpha signaling. Hum Mol Genet N/A:N/A (2013). Functional Studies ; Human . PubMed: 24365713
  • van den Bosch BJ  et al. Defective NDUFA9 as a novel cause of neonatally fatal complex I disease. J Med Genet 49:10-5 (2012). Functional Studies . PubMed: 22114105
  • Li FC  et al. Bioenergetics failure and oxidative stress in brain stem mediates cardiovascular collapse associated with fatal methamphetamine intoxication. PLoS One 7:e30589 (2012). Functional Studies ; Rat . PubMed: 22276218
  • Yuan Y  et al. Activation of peroxisome proliferator-activated receptor-? coactivator 1a ameliorates mitochondrial dysfunction and protects podocytes from aldosterone-induced injury. Kidney Int N/A:N/A (2012). PubMed: 22648295
  • Devi L & Ohno M Mitochondrial dysfunction and accumulation of the ß-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice. Neurobiol Dis : (2011). Functional Studies ; Mouse . PubMed: 21933711
  • Favaro E  et al. MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU. PLoS One 5:e10345 (2010). PubMed: 20436681
  • McIntosh R  et al. The critical role of intracellular zinc in adenosine A(2) receptor activation induced cardioprotection against reperfusion injury. J Mol Cell Cardiol 49:41-7 (2010). PubMed: 20144616
  • Li Q  et al. ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import. Proc Natl Acad Sci U S A 107:21146-51 (2010). Functional Studies ; Rat . PubMed: 21078990

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