Overview

  • Product name

    Compound 401, DNA-dependent protein kinase and mTOR inhibitor
  • Description

    Selective, reversible DNA-dependent protein kinase and mTOR inhibitor
  • Biological description

    Selective, reversible DNA-dependent protein kinase and mTOR inhibitor (IC50 values are 0.28 and 5.3 μM respectively). No affinity for PI3K, ATM and ATR (IC50 values are >100 μM). Able to induce apoptosis in vitro. Cell-permeable.
  • Purity

    > 99%
  • CAS Number

    168425-64-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one
  • Molecular weight

    281.31
  • Molecular formula

    C16H15N3O2
  • PubChem identifier

    10039361
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C2C=C(N=C1c3ccccc3C=CN12)N4CCOCC4
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ballou LM  et al. Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)pyrimido[2,1-alpha]isoquinolin-4-one. J Biol Chem 282:24463-70 (2007). Read more (PubMed: 17562705) »
  • Griffin RJ  et al. Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. J Med Chem 48:569-85 (2005). Read more (PubMed: 15658870) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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