Key features and details
- CD40-TRAF6 interaction inhibitor
- CAS Number: 433249-94-6
- Purity: > 99%
- Soluble in ethanol to 100 mM and in DMSO to 100mM
- Form / State: Solid
- Source: Synthetic
Product nameCompound 6877002, CD40-TRAF6 interaction inhibitor
DescriptionCD40-TRAF6 interaction inhibitor
- CD40-TRAF6 signaling inhibitor
CD40-TRAF6 interaction inhibitor. Small molecule that binds to TRAF6, blocking interactions with CD40. Suppresses CD40-induced IL-1β and IL-6 expression in primary macrophages in vitro. Improves insulin sensitivity, reduces adipose tissue inflammation, and ameliorates hepatosteatosis in a mouse diet-induced obesity model.
Storage instructionsShipped at 4°C. Store at +4°C.
Solubility overviewSoluble in ethanol to 100 mM and in DMSO to 100mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab146829 has been referenced in 1 publication.
- Wu X et al. Traf6 inhibitor boosts antitumor immunity by impeding regulatory T cell migration in Hepa1-6 tumor model. Int Immunopharmacol 77:105965 (2019). PubMed: 31670092