Anti-COMT antibody (ab226938)

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Overview

  • Product name

    Anti-COMT antibody
    See all COMT primary antibodies

  • Description

    Rabbit polyclonal to COMT

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WB, IHC-Pmore details

  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rhesus monkey

  • Immunogen

    Recombinant fragment within Human COMT (internal sequence). The exact sequence is proprietary.
    Database link: P21964

  • Positive control

    • WB: MOLT-4 whole cell lysate; Mouse spleen lysate. IHC-P: Human colon carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab226938 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 30 kDa.
IHC-P 1/100 - 1/1000.

Target

  • Function

    Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

  • Tissue specificity

    Brain, liver, placenta, lymphocytes and erythrocytes.

  • Sequence similarities

    Belongs to the mammalian catechol-O-methyltransferase family.

  • Post-translational
    modifications

    The N-terminus is blocked.

  • Cellular localization

    Cytoplasm and Cell membrane.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • Catechol O methyltransferase antibody
    • Catechol O-methyltransferase antibody
    • COMT antibody
    • COMT_HUMAN antibody
    • EC 2.1.1.6 antibody
    see all

Images

  • Western blot - Anti-COMT antibody (ab226938)
    Western blot - Anti-COMT antibody (ab226938)
    Anti-COMT antibody (ab226938) at 1/500 dilution + Mouse spleen lysate at 50 µg

    Predicted band size: 30 kDa



    12 % SDS-PAGE gel.

  • Western blot - Anti-COMT antibody (ab226938)
    Western blot - Anti-COMT antibody (ab226938)
    Anti-COMT antibody (ab226938) at 1/1000 dilution + MOLT-4 (human lymphoblastic leukemia cell line) whole cell lysate at 30 µg

    Predicted band size: 30 kDa



    12 % SDS-PAGE gel.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COMT antibody (ab226938)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COMT antibody (ab226938)

    Paraffin-embedded human colon carcinoma tissue stained for COMT with ab226938 at 1/250 dilution in immunohistochemical analysis.

References

ab226938 has not yet been referenced specifically in any publications.

Publishing research using ab226938? Please let us know so that we can cite the reference in this datasheet.

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