Concanamycin A (Folimycin). Potent, selective vacuolar-type H+-ATPase inhibitor.  (ab144227)

Overview

  • Product name

    Concanamycin A (Folimycin). Potent, selective vacuolar-type H+-ATPase inhibitor. 
  • Description

    Potent, selective vacuolar-type H+-ATPase inhibitor. Macrolide antibiotic agent.
  • Alternative names

    • Folimycin
  • Biological description

    Potent, selective vacuolar-type H+-ATPase inhibitor (Ki = 0.02 nM). Macrolide antibiotic agent. Concanamycin B and C (ab144228 and ab144229, respectively) analog. Shows antiproliferative and potent antifungal effects. Shows antimalarial effects in vivo.
  • Purity

    > 98%
  • CAS Number

    80890-47-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(Aminocarbonyl)-2,6-dideoxy-β-D-arabinohexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propen-1-yl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one
  • Molecular weight

    866.10
  • Molecular formula

    C46H75NO14
  • PubChem identifier

    6438151
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC[C@H]1[C@H]([C@@H](C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)/C=C/C)C)O[C@H]3C[C@H]([C@@H]([C@H](O3)C)OC(=O)N)O)O)O)OC)/C)C)O
  • Source

    Streptomyces sp.

  • Research areas

References

This product has been referenced in:

  • Auparakkitanon S & Wilairat P Antimalarial activity of concanamycin A alone and in combination with pyronaridine. Southeast Asian J Trop Med Public Health 37:619-21 (2006). Read more (PubMed: 17121284) »
  • Huss M  et al. Concanamycin A, the specific inhibitor of V-ATPases, binds to the V(o) subunit c. J Biol Chem 277:40544-8 (2002). Read more (PubMed: 12186879) »
  • Kinashi H  et al. Isolation and characterization of concanamycins A, B and C. J Antibiot (Tokyo) 37:1333-43 (1984). Read more (PubMed: 6511660) »
See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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