Key features and details
- Potent, selective vacuolar type H+-ATPase inhibitor. Antibiotic agent.
- CAS Number: 81552-33-2
- Purity: > 98%
- Soluble in DMSO
- Form / State: Solid
- Source: Streptomyces sp.
Product nameConcanamycin B, H+-ATPase inhibitor
DescriptionPotent, selective vacuolar type H+-ATPase inhibitor. Antibiotic agent.
Chemical name[(2R,3S,4R,6R)-6-[(2R,4R,5S,6R)-2-[(2S,3R,4S)-4-[(2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-10,12-dihydroxy-3,17-dimethoxy-7,9,11,13,15-pentamethyl-18-oxo-1-oxacyclooctadeca-4,6,14,16-tetraen-2-yl]-3-hydroxypentan-2-yl]-2-hydroxy-5-methyl-6-[(E)-prop-1-enyl]oxan-4-yl]oxy-4-hydroxy-2-methyloxan-3-yl] carbamate
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144228 has been referenced in 1 publication.
- Montealegre S et al. The role of MHC class I recycling and Arf6 in cross-presentation by murine dendritic cells. Life Sci Alliance 2:N/A (2019). PubMed: 31740564