Overview

  • Product name

    Concanamycin C, H+-ATPase inhibitor
  • Description

    Potent, selective vacuolar-type H+-ATPase inhibitor. Macrolide antibiotic agent.
  • Biological description

    Potent, selective vacuolar-type H+-ATPase inhibitor. Macrolide antibiotic agent. Concanamycin A (ab144227) analog. Shows antiproliferative and potent antifungal effects.
  • Purity

    > 98%
  • CAS Number

    81552-34-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3Z,5E,7R,8R,9S,10S,11R,13E,17S,18R)-18-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-4-[(2R,4R,5S,6R)-4,5-Dihydroxy-6-methyloxan-2-yl]oxy-2-hydroxy-5-methyl-6-[(E)-prop-1-enyl]oxan-2-yl]-3-hydroxypentan-2-yl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyl-1-oxacyclooctadeca-3,5,13,15-tetraen-2-one
  • Molecular weight

    823.06
  • Molecular formula

    C45H74O13
  • PubChem identifier

    71311712
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC[C@H]1[C@H]([C@@H](C/C(=C/C=C[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)/C=C/C)C)O[C@H]3C[C@H]([C@@H]([C@H](O3)C)O)O)O)O)OC)/C)C)O
  • Source

    Streptomyces sp.

  • Research areas

References

This product has been referenced in:

  • Dröse S  et al. Semisynthetic derivatives of concanamycin A and C, as inhibitors of V- and P-type ATPases: structure-activity investigations and developments of photoaffinity probes. Biochemistry 40:2816-25 (2001). Read more (PubMed: 11258892) »
  • Bowman EJ & Bowman BJ Cellular role of the V-ATPase in Neurospora crassa: analysis of mutants resistant to concanamycin or lacking the catalytic subunit A. J Exp Biol 203:97-106 (2000). Read more (PubMed: 10600678) »
  • Kinashi H  et al. Isolation and characterization of concanamycins A, B and C. J Antibiot (Tokyo) 37:1333-43 (1984). Read more (PubMed: 6511660) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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