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    conjugated-noradrenaline-antibody-ab6454.pdf

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Neuroscience Neurotransmitter Biogenic Amines Noradrenaline
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Anti-Conjugated Noradrenaline antibody (ab6454)

  • Datasheet
  • SDS
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Key features and details

  • Rabbit polyclonal to Conjugated Noradrenaline
  • Suitable for: ELISA, IHC-Fr
  • Reacts with: Species independent
  • Isotype: IgG

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Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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Overview

  • Product name

    Anti-Conjugated Noradrenaline antibody
  • Description

    Rabbit polyclonal to Conjugated Noradrenaline
  • Host species

    Rabbit
  • Specificity

    Using catecholamine-Glutaraldehyde-BSA conjugates, antibody specificity was performed with an ELISA test by competition experiments, as follows: (a) unconjugated or conjugated catecholamine concentration at half displacement (b) Non-reduced conjugate
    CompoundCross-reactivity ratio (a)
    Noradrenaline1
    Octopamine1/31
    Dopamine1/70
    Adrenaline1/177
    Noradrenaline (b)1/316
    L-DOPA, Tyramine, unconjugated Noradrenaline1/>5000
  • Tested applications

    Suitable for: ELISA, IHC-Frmore details
  • Species reactivity

    Reacts with: Species independent
  • Immunogen

    Synthetic noradrenaline conjugated to protein carriers (PC).

  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Concentration information loading...
  • Purity

    Ammonium Sulphate Precipitation
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Neuroscience
    • Neurotransmitter
    • Biogenic Amines
    • Noradrenaline
    • Signal Transduction
    • Growth Factors/Hormones
    • Adrenalin

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab6454 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
IHC-Fr
Notes
  • Application notes
    Immunohistochemistry: 1/2000 - 1/5000. Tested using a PAP techique on free floating rat locus coeruleus.
    ELISA: assay dependent.
    Not tested in other applications.

    Optimal dilutions / concentrations should be determined by the end user.
  • Target

    • Relevance

      Noradrenaline (NA) is a catecholamine neurotransmitter at postganglionic sympathetic fibres, produced following a series of steps from the essential amino acid phenylalanine. Terminal postganglionic sympathetic fibres have varicosities (where NA is synthesised and stored) which form synapses with the effector organ. The adrenal medulla is a major source of catecholamines (such as NA and adrenaline), however, most of the NA produced in the adrenal medulla is converted into adrenaline. NA is key in the fight-or-flight response and also directly increases heart rate, energy release from fat, and muscle readiness.

    Protocols

    • Immunohisto and cytochemistry

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (2)

    Publishing research using ab6454? Please let us know so that we can cite the reference in this datasheet.

    ab6454 has been referenced in 2 publications.

    • Aschrafi A  et al. Angiotensin II mediates the axonal trafficking of tyrosine hydroxylase and dopamine ß-hydroxylase mRNAs and enhances norepinephrine synthesis in primary sympathetic neurons. J Neurochem 150:666-677 (2019). PubMed: 31306490
    • Arima Y  et al. Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit. Elife 6:N/A (2017). PubMed: 28809157

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