Key features and details
- Rabbit polyclonal to Constitutive androstane receptor
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Constitutive androstane receptor antibody
See all Constitutive androstane receptor primary antibodies
DescriptionRabbit polyclonal to Constitutive androstane receptor
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Chimpanzee, Rhesus monkey
- Human brain cerebellum tissue: Jurkat cell extracts.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 0.88% Sodium chloride, 50% Glycerol
PBS without Mg2+, Ca2+
Concentration information loading...
PurityImmunogen affinity purified
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
Our Abpromise guarantee covers the use of ab189316 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 40 kDa.|
|IHC-P||Use a concentration of 20 µg/ml.|
FunctionBinds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
Tissue specificityPredominantly expressed in liver.
Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
DomainComposed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
modificationsPhosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation.
Cellular localizationNucleus. Cytoplasm. Cytoplasm > cytoskeleton. Recruited to the cytoplasm by DNAJC7.
- Information by UniProt
- CAR antibody
- CAR BETA antibody
- CAR1 antibody
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain, cerebellum tissue labeling Constitutive androstane receptor with ab189316 at 20 µg/ml.
All lanes : Anti-Constitutive androstane receptor antibody (ab189316) at 1/500 dilution
Lane 1 : Jurkat cell extract treated with 20% serum for 15 minutes
Lane 2 : Jurkat cell extract treated with 20% serum for 15 minutes with synthesized peptide
Predicted band size: 40 kDa
ab189316 has not yet been referenced specifically in any publications.