Overview

  • Product name

    Anti-Constitutive androstane receptor antibody
    See all Constitutive androstane receptor primary antibodies
  • Description

    Rabbit polyclonal to Constitutive androstane receptor
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Human, Chimpanzee, Rhesus monkey
  • Immunogen

    Recombinant fragment within Human Constitutive androstane receptor (internal sequence). The exact sequence is proprietary.
    Database link: Q14994

  • Positive control

    • WB: Mouse liver lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab228767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 40 kDa.

Target

  • Function

    Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
  • Tissue specificity

    Predominantly expressed in liver.
  • Sequence similarities

    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Domain

    Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
  • Post-translational
    modifications

    Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation.
  • Cellular localization

    Nucleus. Cytoplasm. Cytoplasm > cytoskeleton. Recruited to the cytoplasm by DNAJC7.
  • Information by UniProt
  • Database links

  • Alternative names

    • CAR antibody
    • CAR BETA antibody
    • CAR1 antibody
    • CARA antibody
    • Constitutive activator of retinoid response antibody
    • constitutive active receptor antibody
    • Constitutive active response antibody
    • constitutive androstane nuclear receptor variant 2 antibody
    • constitutive androstane nuclear receptor variant 3 antibody
    • constitutive androstane nuclear receptor variant 4 antibody
    • constitutive androstane nuclear receptor variant 5 antibody
    • Constitutive androstane receptor antibody
    • MB67 antibody
    • MGC97144 antibody
    • NR1I3 antibody
    • NR1I3_HUMAN antibody
    • Nuclear receptor subfamily 1 group I member 3 antibody
    • orphan nuclear hormone receptor antibody
    • Orphan nuclear receptor MB67 antibody
    • Orphan nuclear receptor NR1I3 antibody
    see all

Images

  • Anti-Constitutive androstane receptor antibody (ab228767) at 1/1000 dilution + Mouse liver lysate at 50 µg

    Predicted band size: 40 kDa



    12% SDS-PAGE gel.

References

ab228767 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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