Overview

  • Product name

  • Description

    Goat polyclonal to Contactin 1
  • Host species

    Goat
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
    Predicted to work with: Guinea pig, Cow, Pig, Chimpanzee, Monkey, Gorilla
  • Immunogen

    Synthetic peptide corresponding to Human Contactin 1 aa 313-324 (internal sequence) (Cysteine residue). (NP_001834.2; NP_778203.1; NP_001242992.1).
    Sequence:

    ENIRGKDKHQAR


    Database link: Q12860

  • Positive control

    • Human brain cerebellum tissue; Human brain cerebellum, Mouse and Rat brain tissue lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab191285 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml.
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 113 kDa.

Target

  • Function

    Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
  • Tissue specificity

    Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.
  • Involvement in disease

    Defects in CNTN1 are the cause of Compton-North congenital myopathy (CNCM) [MIM:612540]. CNCM is a familial lethal form of congenital onset muscle weakness, inherited in an autosomal-recessive fashion and characterized by a secondary loss of beta2-syntrophin and alpha-dystrobrevin from the muscle sarcolemma, central nervous system involvement, and fetal akinesia.
  • Sequence similarities

    Belongs to the immunoglobulin superfamily. Contactin family.
    Contains 4 fibronectin type-III domains.
    Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CNTN 1 antibody
    • CNTN antibody
    • Cntn1 antibody
    • CNTN1_HUMAN antibody
    • Contactin-1 antibody
    • Contactin1 antibody
    • F3 antibody
    • F3cam antibody
    • Glycoprotein gp135 antibody
    • gp 135 antibody
    • GP135 antibody
    • MYPCN antibody
    • Neural cell surface protein F3 antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Human brain cerebellum tissue labeling Contactin 1 with ab191285 at 5 µg/ml.

  • All lanes : Anti-Contactin 1 antibody (ab191285) at 0.3 µg/ml

    Lane 1 : Human cerebellum tissue lysate in RIPA buffer at 35 µg
    Lane 2 : Mouse brain tissue lysate in RIPA buffer at 35 µg
    Lane 3 : Rat brain tissue lysate in RIPA buffer

    Predicted band size: 113 kDa



    The observed molecular weight corresponds to the glycosylated form.

References

ab191285 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab191285.
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