• Product name

  • Description

    Goat polyclonal to Contactin 1
  • Host species

  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
    Predicted to work with: Guinea pig, Cow, Pig, Chimpanzee, Monkey, Gorilla
  • Immunogen

    Synthetic peptide corresponding to Human Contactin 1 aa 313-324 (internal sequence) (Cysteine residue). (NP_001834.2; NP_778203.1; NP_001242992.1).


    Database link: Q12860

  • Positive control

    • Human brain cerebellum tissue; Human brain cerebellum, Mouse and Rat brain tissue lysates.



Our Abpromise guarantee covers the use of ab191285 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml.
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 113 kDa.


  • Function

    Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
  • Tissue specificity

    Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.
  • Involvement in disease

    Defects in CNTN1 are the cause of Compton-North congenital myopathy (CNCM) [MIM:612540]. CNCM is a familial lethal form of congenital onset muscle weakness, inherited in an autosomal-recessive fashion and characterized by a secondary loss of beta2-syntrophin and alpha-dystrobrevin from the muscle sarcolemma, central nervous system involvement, and fetal akinesia.
  • Sequence similarities

    Belongs to the immunoglobulin superfamily. Contactin family.
    Contains 4 fibronectin type-III domains.
    Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CNTN 1 antibody
    • CNTN antibody
    • Cntn1 antibody
    • CNTN1_HUMAN antibody
    • Contactin-1 antibody
    • Contactin1 antibody
    • F3 antibody
    • F3cam antibody
    • Glycoprotein gp135 antibody
    • gp 135 antibody
    • GP135 antibody
    • MYPCN antibody
    • Neural cell surface protein F3 antibody
    see all


  • Immunohistochemical analysis of formalin fixed, paraffin embedded Human brain cerebellum tissue labeling Contactin 1 with ab191285 at 5 µg/ml.

  • All lanes : Anti-Contactin 1 antibody (ab191285) at 0.3 µg/ml

    Lane 1 : Human cerebellum tissue lysate in RIPA buffer at 35 µg
    Lane 2 : Mouse brain tissue lysate in RIPA buffer at 35 µg
    Lane 3 : Rat brain tissue lysate in RIPA buffer

    Predicted band size: 113 kDa

    The observed molecular weight corresponds to the glycosylated form.


ab191285 has not yet been referenced specifically in any publications.

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