Overview

  • Product name

    Anti-Contactin 1 antibody - C-terminal
    See all Contactin 1 primary antibodies
  • Description

    Rabbit polyclonal to Contactin 1 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Frmore details
  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Rat, Cow, Human, Rhesus monkey
  • Immunogen

    Recombinant fragment within Human Contactin 1 (C terminal). The exact sequence is proprietary.
    Database link: Q12860

  • Positive control

    • IHC-Fr: Embryonic mouse brain and adult mouse retina tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab227491 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr 1/100 - 1/1000.

Target

  • Function

    Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
  • Tissue specificity

    Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.
  • Involvement in disease

    Defects in CNTN1 are the cause of Compton-North congenital myopathy (CNCM) [MIM:612540]. CNCM is a familial lethal form of congenital onset muscle weakness, inherited in an autosomal-recessive fashion and characterized by a secondary loss of beta2-syntrophin and alpha-dystrobrevin from the muscle sarcolemma, central nervous system involvement, and fetal akinesia.
  • Sequence similarities

    Belongs to the immunoglobulin superfamily. Contactin family.
    Contains 4 fibronectin type-III domains.
    Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CNTN 1 antibody
    • CNTN antibody
    • Cntn1 antibody
    • CNTN1_HUMAN antibody
    • Contactin-1 antibody
    • Contactin1 antibody
    • F3 antibody
    • F3cam antibody
    • Glycoprotein gp135 antibody
    • gp 135 antibody
    • GP135 antibody
    • MYPCN antibody
    • Neural cell surface protein F3 antibody
    see all

Images

  • Frozen sections of embryonic mouse brain (mE18.5) tissue stained for Contactin 1 (red) using ab227491 at 1/250 dilution in immunohistochemical analysis.

    Nuclear counterstain: DAPI (blue).

  • Frozen sections of adult mouse retina tissue stained for Contactin 1 (green) using ab227491 at 1/250 dilution in immunohistochemical analysis.

    Counterstain: beta Tubulin 3, stained by beta Tubulin 3 antibody (red) at 1/250 dilution.

    Nuclear counterstain: DAPI (blue).

References

ab227491 has not yet been referenced specifically in any publications.

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