Overview

  • Product name

  • Description

    Rabbit polyclonal to Contactin 6
  • Host species

    Rabbit
  • Specificity

    Specificity of this product was demonstrated by immunohistochemistry where neurons were intensely stained in rat dorsal root ganglia. Oligodendrocytes in the rat trigeminal nerve root are also stained.
  • Tested applications

    Suitable for: ELISA, IHC-Frmore details
  • Species reactivity

    Reacts with: Rat
  • Immunogen

    A peptide corresponding to an antigenic region within the carboxy-terminal domain of the rat Contactin 6 protein. This peptide was conjugated to carrier protein to enhance the immunological response.

Properties

Applications

Our Abpromise guarantee covers the use of ab49207 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
IHC-Fr
  • Application notes
    1 site ELISA: 1/5000.
    IHC-Fr: 1/4000.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination.
    • Tissue specificity

      Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord.
    • Sequence similarities

      Belongs to the immunoglobulin superfamily. Contactin family.
      Contains 4 fibronectin type-III domains.
      Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
    • Cellular localization

      Cell membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • CNTN 6 antibody
      • CNTN6 antibody
      • CNTN6_HUMAN antibody
      • Contactin 6 precursor antibody
      • Contactin-6 antibody
      • Contactin6 antibody
      • hNB 3 antibody
      • hNB-3 antibody
      • hNB3 antibody
      • MGC133256 antibody
      • NB 3 antibody
      • NB3 antibody
      • Neural adhesion molecule antibody
      • Neural recognition molecule NB 3 antibody
      • Neural recognition molecule NB-3 antibody
      see all

    References

    ab49207 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Application
    Immunohistochemistry (Frozen sections)
    Sample
    Mouse Tissue sections (brain)
    Permeabilization
    Yes - -20 Methanol, 1 min
    Specification
    brain
    Blocking step
    3% BSA, 5%Donkey serum as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 3% · Temperature: RT°C
    Fixative
    Paraformaldehyde

    Dr. Nina Mayorek

    Verified customer

    Submitted Nov 16 2017

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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