For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome

Hello. We're improving abcam.com and we'd welcome your feedback.

Hello. We're improving abcam.com and we'd welcome your feedback.

Infomation icon

We haven't added this to the BETA yet

New BETA website

New BETA website

Hello. We're improving abcam.com and we'd welcome your feedback.

Take a look at our BETA site and see what we’ve done so far.

Switch on our new BETA site

Now available

Search and browse selected products

  • A selection of primary antibodies

Purchase these through your usual distributor

In the coming months

  • Additional product types
  • Supporting content
  • Sign in to your account
  • Purchase online
United States
Your country/region is currently set to:

If incorrect, please enter your country/region into the box below, to view site information related to your country/region.

Call (888) 77-ABCAM (22226) or contact us
Need help? Contact us

  • My account
  • Sign out
Sign in or Register with us

Welcome

Sign in or

Don't have an account?

Register with us
My basket
Quick order
Abcam homepage

  • Research Products
    By product type
    Primary antibodies
    Secondary antibodies
    ELISA and Matched Antibody Pair Kits
    Cell and tissue imaging tools
    Cellular and biochemical assays
    Proteins and Peptides
    By product type
    Proteomics tools
    Agonists, activators, antagonists and inhibitors
    Cell lines and Lysates
    Multiplex miRNA assays
    Multiplex Assays
    By research area
    Cancer
    Cardiovascular
    Cell Biology
    Epigenetics
    Metabolism
    Developmental Biology
    By research area
    Immunology
    Microbiology
    Neuroscience
    Signal Transduction
    Stem Cells
  • Customized Products & Partnerships
    Customized Products & Partnerships

    Customized products and commercial partnerships to accelerate your diagnostic and therapeutic programs.

    Customized products

    Partner with us

  • Support
    Support hub

    Access advice and support for any research roadblock

    View support hub

    Protocols

    Your experiments laid out step by step

    View protocols

  • Events
    • Conference calendar
    • Cancer
    • Cardiovascular
    • Epigenetics & Nuclear signaling
    • Immunology
    • Neuroscience
    • Stem cells
    • Tradeshows
    • Scientific webinars
    Keep up to date with the latest events

    Full event breakdown with abstracts, speakers, registration and more

    View global event calendar

  • Pathways
    Cell signalling pathways

    View all pathways

    View all interactive pathways

Alpha-synuclein

Related

  • Browse by Target

    Alpha-synuclein, or SNCA, was among the first genes to be linked to Parkinson’s disease (PD) and remains one of the most promising targets to unlock Parkinson’s pathogenesis. SNCA has a molecular weight of 14kDa and consists of 140 amino acids. SNCA is abundant in the brain and is largely localized to presynaptic terminals, which are critical in relaying signals between cells.

    PD is the second most common neurodegenerative disorder. It is characterized by the relatively selective loss of dopaminergic neuronal cells in the substantia nigra pars compacta (an area responsible for motor control), and the presence of Lewy bodies, a type of intraneuronal aggregate. SNCA is a major component of these Lewy bodies, whose build-up within dopaminergic neuronal cells is thought to be associated with the dysfunctional and eventual death of these cells. This ultimately leads to the loss of motor control associated with PD.

    In addition to PD, SNCA is associated with multiple other disease states, collectively known as synucleinopathies1,2.


    Applications
    ​

    Our range of SNCA antibodies, kits and proteins are validated for a variety of key applications including western blot, immunohistochemistry, immunocytochemistry, flow cytometry, ELISA, and immunoprecipitation.



    ​IHC image of SNCA staining in Normal human Substantia Nigra formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab138501, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha-synuclein antibody [MJFR1] (ab138501)


    Product recommendations for your alpha-synuclein research​




    Anti-SNCA antibodiesApplicationsSpecies
    Anti-Alpha-synuclein antibody [MJFR1] (ab138501)ELISA, Flow Cyt, ICC/IF, IHC-P, IP, WBHuman
    Anti-Alpha-synuclein filament antibody [MJFR-14-6-4-2] - Conformation-Specific (ab209538)Dot, ICC/IF, IHC-FoFr, IHC-PHuman, Mouse, Rat
    Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y] (ab51253)Dot, ELISA, ICC/IF, IHC-FrFl, IHC-P, WBHuman, Mouse, Rat
    Anti-Alpha-synuclein (phospho S129) antibody [MJF-R13 (8-8)] (ab168381)WBHuman
    Anti-Alpha-synuclein antibody [MJFR1] (Alexa Fluor® 488) (ab195025)Flow CytHuman, Mouse
    Anti-Alpha-synuclein filament antibody [MJFR-14-6-4-2] - Conformation-Specific (Alexa Fluor® 488) (ab216124)IHC-FrHuman
    SNCA ELISA and Assay kitsSensitivity RangeDetection
    Human Alpha-synuclein ELISA Kit (ab210973)*1.563 ng/ml - 100 ng/mlColorimetric
    KO Cell lines

    Human SNCA knockout HEK293T cell line (ab255433)

    Human SNCA knockout HEK293T cell lysate (ab263769)

    SNCA proteinApplications
    Recombinant Human Alpha-synuclein protein aggregate (Active) (ab218819)FuncS, SDS-PAGE, WB
    Recombinant Human Alpha-synuclein protein (ab51189)SDS-PAGE, WB
    Recombinant Human Alpha-synuclein protein monomer (Active) (ab218818)FuncS, SDS-PAGE, WB
    Recombinant Human Alpha-synuclein protein aggregate (Type 2) (ab218817)FuncS, SDS-PAGE
    Recombinant Human Alpha-synuclein protein (1-112aa) (ab48842)SDS-PAGE
    Recombinant Human Alpha-synuclein protein monomer (Type 2) (ab218816)SDS-PAGE

    *This kit is part of the SimpleStep ELISA® range

    ​Discover our full range of products to alpha-synuclein.


    References
    ​

    1. Burré J. The Synaptic Function of α-Synuclein J Parkinsons Dis. 5(4): 699–713 (2015)
    2. Xu L, Pu J. Alpha-Synuclein in Parkinson's Disease: From Pathogenetic Dysfunction to Potential Clinical Application Parkinsons Dis. 2016;2016:1720621. doi: 10.1155/2016/1720621. Epub 2016 Aug 17.
    Burré J. The Synaptic Function of α-Synuclein J Parkinsons Dis. 2015; 5(4): 699–713
    Xu L, Pu J. Alpha-Synuclein in Parkinson's Disease: From Pathogenetic Dysfunction to Potential Clinical Application Parkinsons Dis. 2016;2016:1720621. doi: 10.1155/2016/1720621. Epub 2016 Aug 17.






    Get resources and offers direct to your inbox Sign up
    A-Z by research area
    • Cancer
    • Cardiovascular
    • Cell biology
    • Developmental biology
    • Epigenetics & Nuclear signaling
    • Immunology
    • Metabolism
    • Microbiology
    • Neuroscience
    • Signal transduction
    • Stem cells
    A-Z by product type
    • Primary antibodies
    • Secondary antibodies
    • Biochemicals
    • Isotype controls
    • Flow cytometry multi-color selector
    • Kits
    • Loading controls
    • Lysates
    • Peptides
    • Proteins
    • Slides
    • Tags and cell markers
    • Tools & Reagents
    Help & support
    • Support
    • Make an Inquiry
    • Protocols & troubleshooting
    • Placing an order
    • RabMAb products
    • Biochemical product FAQs
    • Training
    • Browse by Target
    Company
    • Corporate site
    • Investor relations
    • Company news
    • Careers
    • About us
    • Blog
    Events
    • Tradeshows
    • Conferences
    International websites
    • abcam.cn
    • abcam.co.jp

    Join with us

    • LinkedIn
    • facebook
    • Twitter
    • YouTube
    • Terms of sale
    • Website terms of use
    • Cookie policy
    • Privacy policy
    • Legal
    • Modern slavery statement
    © 1998-2023 Abcam plc. All rights reserved.