Dynamin and endocytosis inhibitors

An introduction to dynamin and endocytosis with a simple reference guide of inhibitors for your research.

Dynamin is a key GTPase involved in various forms of endocytosis and is comprised of 3 major isoforms, all of which have four main functional domains.

In addition to being a key component of endocytosis, dynamin participates in cell cycle progression and has also been shown to have critical roles in centrosome cohesion and cytokinesis.

Dynamin inhibitors inhibit different domains of dynamin, leading to subsequent inhibition of endocytosis. Consequently, the dynamin inhibitors have wide-spread application allowing investigation of cell signalling pathways, the cell cycle and cellular division, in addition to other medical conditions such as cancer, neurological conditions and infectious diseases such as botulism and HIV.


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Contents


Dynamin inhibitors available 

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Name

Description

Reference

Dynole 2-24™

Novel, potent dynamin I and II inhibitor


Dyngo4a™

Novel, highly potent dynamin inhibitor. Dynasore (Asc-192) analog.

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Rhodadyn C10™

Highly potent cell permeable dynamin I inhibitor


Rhodadyn B10™

Negative control for Rhodadyn C10™


Dynole-34-2™

Potent dynamin I and dynamin II inhibitor

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Dynole-31-2™

Negative control for Dynole 34-2™

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Pitstop 2™

Novel, selective cell permeable clathrin inhibitor

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Iminodyn 17™

Negative control for Iminodyn-22™


Iminodyn 22™

Potent, broad-spectrum dynamin inhibitor


RTIL-13™

Potent dynamin I and II inhibitor


MiTMAB™

Cell-permeable dynamin I and dynamin II inhibitor

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OctMab™

Cell-permeable dynamin I and dynamin II inhibitor


Pro-myristic acid

Negative control for MiTMAB™ and OcTMAB™


Dynamin Inhibitors Toolbox

Dynamin inhibitor kit from the MiTMAB™, Dynole™, and Iminodyn™ chemical series.

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Dynamin Inhibitors: Iminodyn™ Series Kit

Dynamin inhibitor kit from the Iminodyn™ series

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Dynamin Inhibitors: MiTMAB™ Series Kit

Dynamin inhibitor kit from the MiTMAB™ series

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Dynamin Inhibitors: Dynole™ Series Kit

Dynamin inhibitor kit from the Dynole™ series



References

  • Hill TA et al. Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. J Med Chem 53:4094-102 (2010). 

Read more (PubMed: 20426422)

  • Hill TA et al. Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. J Med Chem 25:3762-73 (2009). 

Read more (PubMed: 19459681)

  • Doherty GJ and McMahon HT. Mechanisms of endocytosis. Annu Rev Biochem 78:857-902 (2009). 

Read more (PubMed: 19317650)

  
Recommended resources from our technical team

  • Doherty GJ and McMahon HT. Mechanisms of endocytosis. Annu Rev Biochem 78:857-902 (2009). 

Read more (PubMed: 19317650)

  • Granseth B et al. Clathrin mediated endocytosis: the physiological mechanism of vesicle retrieval at hippocampal synapses. J Physiol 15:681-6 (2007). 

Read more (PubMed: 17599959)

  • Mettlen M et al. Dissecting dynamin's role in clathrin-mediated endocytosis. Pharmacol Ther 47:233-66 (2009) 

Read more (Pubmed: 1975444)


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