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Dynamin is a key GTPase involved in various forms of endocytosis and is comprised of 3 major isoforms, all of which have four main functional domains.
In addition to being a key component of endocytosis, dynamin participates in cell cycle progression and has also been shown to have critical roles in centrosome cohesion and cytokinesis.
Dynamin inhibitors inhibit different domains of dynamin, leading to subsequent inhibition of endocytosis. Consequently, the dynamin inhibitors have wide-spread application allowing investigation of cell signalling pathways, the cell cycle and cellular division, in addition to other medical conditions such as cancer, neurological conditions and infectious diseases such as botulism and HIV.
Contents
Dynamin inhibitors available
Name | Description | Reference |
Novel, highly potent dynamin inhibitor. Dynasore (Asc-192) analog. | ||
Highly potent cell permeable dynamin I inhibitor | ||
Negative control for Rhodadyn C10™ | ||
Potent dynamin I and dynamin II inhibitor | ||
Negative control for Dynole 34-2™ | ||
Novel, selective cell permeable clathrin inhibitor | ||
Negative control for Iminodyn-22™ | ||
Potent, broad-spectrum dynamin inhibitor | ||
Potent dynamin I and II inhibitor | ||
Cell-permeable dynamin I and dynamin II inhibitor | ||
Cell-permeable dynamin I and dynamin II inhibitor | ||
Negative control for MiTMAB™ and OcTMAB™ | ||
Dynamin inhibitor kit from the MiTMAB™, Dynole™, and Iminodyn™ chemical series. | ||
Dynamin inhibitor kit from the Iminodyn™ series | ||
Dynamin inhibitor kit from the MiTMAB™ series | ||
Dynamin inhibitor kit from the Dynole™ series |
Dynamin inhibitors activity summary
Name | Dynamin I inhibition (μM) | Dynamin II inhibition (μM) | Synaptic vesicle endocytosis (μM) | Receptor mediated endocytosis (μM) | Reference |
380 nM | 2.6 μM | ||||
1.3 | 14.2 | 41.1 | 5 | ||
>300 | |||||
7.1 | - | - | - | ||
- | - | - | - | ||
450 nM | 390 nM | 108 | 10.7 | ||
2.3 | 7.1 | 9.3 | |||
3.1 | 8.4 | 2.2 | 19.9 | ||
1.9 | 4.4 | 6.7 | |||
9.2 | >300 | ||||
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