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The coronaviruses (CoVs) are a group of large, enveloped, positive-sense, ssRNA viruses belonging to the family Coronaviridae. The coronaviruses get their name from their crown-like appearance and are associated with a range of respiratory, enteric and neurological diseases1. While seven distinct coronaviruses have been identified in humans, the three most clinically relevant are found within the Betacoronavirus genus: MERS-CoV, SARS-CoV, and SARS-CoV-2. SARS-CoV-2 is the latest human coronavirus, having been first isolated in 2020 and causing the COVID-19 disease.
All CoV genomes share a similar organization, with the 5′ two thirds comprising the overlapping ORF1a and ORF1b reading frames that encode 16 nonstructural proteins, while the remaining portion of the genome includes reading frames for the Spike (S), Envelope (E), Membrane (M) and Nucleoprotein (N), in addition to various accessory proteins encoded by certain strains2.
Abcam offers a variety of tools used to help understand and accelerate infectious disease research, including SARS-CoV-2, the coronavirus that causes COVID-19. To help researchers navigate quickly to relevant products, listed below are antibodies and proteins specific for the detection and analysis of human coronaviruses.
When investigating SARS-CoV-2 pathology, rapid and reproducible spatial analyses of clinically relevant tissue samples can be challenging due to the fixation processes required.
Developed in partnership with NanoString, the COVID-19 GeoMx-formatted Antibody Panel provides a custom panel for the GeoMx Immune Profiling Core to enable a spatial analysis of 96 proteins involved in the immune response to SARS-CoV-2 infection.
This panel further expands the protein targets available on the GeoMx® Digital Spatial Profiler to enable a high-plex analysis of key biological pathways mapped to specific regions within infected tissues. The data generated demonstrates the application of this new tool in SARS-CoV-2 formalin-fixed paraffin-embedded (FFPE) tissue samples and how it can be used to better understand the processes underlying infection, pathogenesis and therapeutic response.
|COVID-19 GeoMx-formatted Antibody Panel|
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