Information and products associated with novel coronavirus research
Overview
Coronaviruses, named after their crown-like shape, were first identified in the 1960s and are associated with a range of respiratory symptoms. Cases such as Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV) can cause aggravated symptoms in humans and can lead to pneumonia, severe acute respiratory syndrome and death1,2. SARS-CoV-2 (formally known as 2019-nCoV) is the latest coronavirus strain to be identified.
Coronavirus research
Chinese scientists identified the novel coronavirus as a group 2B CoV, distinct from the SARS-CoV3,4,5. Genome sequencing demonstrated that SARS-CoV-2 (2019-nCoV) shares 79.5% sequence identity with SARS-CoV and 96% of identity with a bat coronavirus6.
To access host cells, coronaviruses attach to specific host cellular receptors via the spike protein7. Thus, SARS-CoV utilizes angiotensin converting enzyme II (ACE-2) host cell receptor whereas MERS-CoV uses CD26 (DPP4)8. The results of several recent studies suggest that SARS-CoV-2 can use the same cell entry receptor, ACE-2, as SARS-CoV6,9,10.
At the time of publishing this page, no vaccine or specific antiviral treatment exists for SARS-CoV-2. Scientists are searching for potential vaccines and therapeutic agents targeting SARS-CoV-2 or host cell components (eg host cell receptors) necessary for viral replication.
Products to support coronavirus research
Abcam offers a variety of tools used to help understand and accelerate infectious disease research, including coronavirus (SARS-CoV-2). To help researchers navigate quickly to relevant products, listed below are antibodies and proteins specific for human coronavirus and cytokine detection products for human coronavirus research.
See a complete list of coronavirus-specific products.
ACE2 receptor antibodies and ELISA kits
| Name | abID | Application | Species |
| Human ACE2 ELISA Kit | ab235649 | ELISA | Human |
| Mouse ACE2 ELISA Kit | ab213843 | ELISA | Mouse |
| Human ACE2 Antibody Pair - BSA and Azide free | ab244135 | ELISA | Human |
Anti-ACE2 antibody | ab87436 | ICC/IF, IHC-P, WB | Human (predicted: Mouse, Rat, Hamster, Cat, Dog, Orangutan) |
| Recombinant Anti-ACE2 antibody [EPR4435(2)] | ab108252 | IHC-P, IP, WB | Mouse, Rat, Human |
| Recombinant Anti-ACE2 antibody [EPR4435(2)] - BSA and Azide free | ab239924 | IHC-P, IP, WB | Mouse, Rat, Human |
| Anti-ACE2 antibody - N-terminal | ab228349 | IHC-P, WB | Mouse, Human (predicted: Rhesus monkey) |
See a complete list of products targeting ACE2 receptors.
Cytokine detection products for human coronavirus research
| Name | abID | Application | Species |
Anti-IL-1 beta antibody | ab9722 | WB, ELISA, Neutralising, IHC-P, ICC, IHC-Fr, IHC-FoFr, ICC/IF | Mouse, Rat, Human |
| Human IL-2 ELISA Kit | ab174444 | ELISA | Human |
| Human IL-6 ELISA Kit | ab178013 | ELISA | Human |
| Anti-IL-6 antibody | ab9324 | ICC/IF, IHC-Fr, IHC-P, Neut, sELISA, WB | Rat, Human |
| Anti-IL-17 antibody | ab79056 | ELISA, ICC/IF, IHC-Fr, IHC-P, WB | Mouse, Dog, Human |
| Human IFN gamma ELISA Kit | ab174443 | ELISA | Human |
| Anti-Interferon gamma antibody | ab9657 | ICC/IF, IHC-P, Neut, sELISA, WB | Mouse, Human, Macaque monkey |
| Anti-IP10 antibody | ab9807 | ELISA, IHC-Fr, IHC-P, Neut, WB | Human |
| Human TNF alpha ELISA Kit | ab181421 | ELISA | Human |
| Anti-TNF alpha antibody | ab6671 | ELISA, ICC/IF, IHC-P, WB | Human, Cynomolgus monkey |
| Human VEGF ELISA Kit | ab222510 | ELISA | Human |
| Anti-VEGFA antibody [VG-1] | ab1316 | ELISA, ICC, ICC/IF, IHC-Fr, IHC-P, IP, WB | Mouse, Rat, Rabbit, Dog, Human |
| Anti-VEGFA antibody [EP1176Y] - C-terminal | ab52917 | Flow Cyt, ICC/IF, IHC-P, IP, WB | Mouse, Human |
See a complete list of cytokine products for your research.
If you are interested in the commercial use of our products, please connect with us at partnerships@abcam.com.
For the latest information on the outbreak, please visit the World Health Organization (WHO) website.
References
1. https://www.who.int/ith/diseases/sars/en/
2. https://www.who.int/emergencies/mers-cov/en/
3.Virological.org. Novel 2019 Coronavirus Genome. Available online: http://virological.org/t/novel-2019-coronavirus-genome/319 (accessed on 28 January 2020).
4. GSAID Database. 2020 Coronavirus. Available online: https://www.gisaid.org/CoV2020/ (accessed on 28 January 2020).
5. https://www.ncbi.nlm.nih.gov/nuccore/MN908947
7. Lim, Y.X., Ng, Y.L., Tam, J.P., Liu, D.X. Human Coronaviruses: A Review of Virus-Host Interactions. Diseases. 4:26 (2016).
8. Lu, G., et al. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature. 500, 227-231 (2013).
10. Letko, M.C., Munster, V. Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV. bioRxiv 2020.