Limited use licenses


Broad Institute Limited License

Abcam provides its modified cell lines that have been generated using CRISPR Cas9 technology under a license agreement with the Broad Institute, Inc. ("Broad") that contains certain limitations and obligations.  By purchasing such modified cell lines, you, (the “Buyer”), hereby agree to use the modified cell lines for your own internal research only, and in accordance with the Limited License below:

  1. the Buyer shall (a) not sell or otherwise transfer Products (including without limitation any material that contains a Product in whole or in part) to any other person or entity or (b) use Products to perform services for the benefit of any other person or entity except as otherwise permitted under license to Buyer from Broad or as otherwise permitted by Broad for non-profit use, as provided at https://www.broadinstitute.org/partnerships/office-strategic-alliances-and-partnering/information-about-licensing-crispr-genome-edi 
  2. the Buyer shall use only the purchased amount of the Products purchased from Company, and shall use Products and components of the Products only for its internal research within the Field, which may include internal research within the Field in connection with product research, but not for the production, manufacture or exploitation of any product or Product or any Commercial Purposes
  3. the Buyer shall use Products in compliance with all applicable laws and regulations, including without limitation applicable human health and animal welfare laws and regulations
  4. the Licensor Parties shall provide no warranties of any kind to the Buyer (statutory or implied) concerning the Patent Rights or Products, including without limitation, as to product quality, condition, description, merchantability, fitness for a particular purpose, non-infringement of intellectual property rights or the absence of latent or other defects, and all such warranties are hereby expressly disclaimed
  5. the Licensor Parties shall expressly disclaim any warranty regarding results obtained through the use of the Products, including without limitation any claim of inaccurate, invalid or incomplete results
  6. the Licensor Parties and their directors, trustees, officers, employees, agents, faculty, affiliated investigators, and students, shall have no liability to the Buyer, including, without limitation, for any loss of use or profits, business interruption or any consequential, incidental, special or other indirect damages of any kind, regardless of how caused and regardless of whether an action in contract, tort, strict product liability or otherwise
  7. the Buyer shall indemnify, defend and hold harmless the Indemnitees against any liability, incurred by or imposed upon any of the Indemnitees, as applicable, in connection with any claims, suits, investigations, actions, demands or judgments arising out of or related to the exercise of any rights granted to the Buyer under the Limited License or any breach of the Limited License by such Buyer, provided that, to the extent the foregoing is not permitted by law, the Buyer agrees, to the extent permitted by law, that it, and not the Indemnitees, as applicable, shall be responsible for any liability, damage, loss or expense arising out of or related to the exercise of any rights granted to the Buyer under the Limited License or any breach of the Limited License by Buyer
  8. the Product and its use may be the subject of one or more issued patents or pending patent applications owned by one or more Licensor Parties and the purchase of the Product does not convey a license under any claims in the foregoing patents or patent applications directed to the Product or use, production or commercialization thereof, except as expressly set forth in the Limited License
  9. this Limited License does not contain any restrictions on the use of Products by non-profit institutions other than those set forth in the foregoing clauses (1) – (8), including without limitation, any reach-through rights (including without limitation any right to receive payment) with respect to products or discoveries made, discovered, derived, identified or selected using such Products.
  10. nothing in this Limited License shall be construed to confer any rights upon Buyer by implication, estoppel, or otherwise as to any technology or patent rights of any entity other than the Patent Rights.  In addition, nothing in this Limited License shall be construed to confer upon Buyer or any Third Party any rights under or to the Patent Rights outside of the Field.

The following definitions apply to the Limited License:


Commercial Purposes means (a) the practice, performance or provision of any method, process or service, or (b) the manufacture, production, sale, use, distribution, disposition or importing of any product, in each case (a) or (b) for consideration of any kind, for the purpose of sale or commercial exploitation, or on any other commercial basis.


Enabled Product means any product, that is not the Licensed Product, which is or incorporates (a) any progeny, modification or derivative of the Licensed Product, or (b) any cell, organism or animal made or modified through use of the Licensed Product, or any progeny, modification or derivative of such cell, organism or animal.  For clarity, any product that is made, produced or derived by use of the technology of the Patent Rights, such as a protein or a peptide from a cell line shall be deemed an Enabled Product; provided, however, that the term Enabled Product shall not include any large or small molecule that(i) was identified or discovered through screening using technology covered by the Patent Rights and (ii) does not otherwise fall within the foregoing clauses (a) through (b).


Field means use as a research tool for research purposes; provided, however, that notwithstanding the foregoing, the Field shall expressly exclude (a) any clinical use, including, without limitation, diagnostic and prognostic use,(b) any human, veterinary, livestock or agricultural use, or (c) the manufacture, distribution, importation, exportation, transportation, sale, offer for sale, marketing, promotion or other exploitation or use of, or as, a testing service, therapeutic or diagnostic for humans or animals.


Indemnitees means each Licensor Party, their affiliates, and their current and former trustees, directors, officers, faculty, affiliated investigators, students, employees, medical and professional staff and agents and their respective successors, heirs and assigns


Licensed Patent Rights means (a) any patents and patent applications listed in the Broad Institute Patent Rights table below; (b) any substitutions, divisions, continuations, reissues, renewals, re-examinations or extensions of any patents or patent applications of (a), any continuations-in-part of any patents or patent applications of (a) to the extent the claims are directed to subject matter specifically described in a patent or patent application set forth on Appendix A, and any application claiming priority to a provisional application listed in the Broad Institute Patent Rights table below, to the extent the claims are directed to subject matter specifically described in a provisional patent application set forth on Appendix A; (c) any letters patents and/or the equivalent issuing therefrom in any jurisdiction based on any of the foregoing; and (d) any foreign or international equivalents of any of the foregoing, including without limitation any applications filed under the Patent Cooperation Treaty.


Licensor Parties means the Broad Institute, Inc.; the President and Fellows of Harvard College, Massachusetts Institute of Technology, University of Iowa Research Foundation; University of Tokyo; Rockefeller University; New York University, New York Genome Center.


Product means any product (a) that is Covered by at least one Claim of the Patent Rights or (b) that is not described in the foregoing clause (a) but that includes, uses, is derived from or is developed, identified or made through the use of technology Covered by at least one Claim of the Patent Rights or a product covered by the foregoing clause (a) (including any biological material, cell, organism or animal so derived, developed, identified or made) and any progeny, modifications, improvements or derivatives thereof; provided, however, that the term “Product” shall not include (A) any therapeutic large or small molecule that (i) was identified through screening using the technology Covered by the Patent Rights and (ii) does not otherwise make use of the Patent Rights or (B) any product that would not otherwise be a Product except for the use of a Product, Process or the technology Covered by at least one Claim of the Patent Rights solely for purposes of Company’s internal quality control or validation.



Broad Institute Patent Rights

EXEMPLARY FAMILY SERIAL NO

PATENT TITLE

PCT/US2013/074611

CRISPR-CAS Component Systems, thods and Compositions for Sequence Manipulation

PCT/US2013/074743

CRISPR-CAS Systems and Methods for Altering Expressions of Gene Products

14/259,420

CRISPR-CAS Systems, Methods and Compositions For Sequence Manipulation in Eukaryotes

PCT/US2013/051418

Inducible DNA Binding Proteins and Genome Perturbation Tools and Applications Thereof

PCT/US2013/074825

Methods, Systems and Apparatus for Identifying Target Seuqences for CAS Enzymes or CRISPR-CAS Systems for Target Sequences and Conveying Results Thereof

PCT/US2013/074812

Methods, Models, Systems and Apparatus for Identifying Target Sequences for CAS Enzymes or CRISPR-CAS Systems for Target Sequences and Conveying Results Thereof

PCT/US2013/074667

Delivery, Engineering and Optimization of Systems Methods and Compositions for Sequence Manipulation and Therapeutic Applications

PCT/US2014/041803

Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Applications

PCT/US2013/074691

Engineering and Optimization of Improved Systems, Methods and Enzyme Compositions for Sequence Manipulation

PCT/US2013/074736

Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation with Functional Domains

PCT/US2013/074819

Engineering of Systems, Methods and Optimized Guide Compositions for Sequence Manipulation

14/855,046

Recombinant Virus And Preparations Thereof

PCT/US2014/041800

Delivery, Engineering and Optimization of Tandem Guide Systems, Methods and Compositions for Sequence Manipulation

PCT/US2014/041806

Fiunctional Genomics Using CRISPR-Cas Systems, Compositions, Methods, Screens and Applications Thereof

PCT/US2014/064663

CRISPR-Related Methods and Compositions with Governing gRNAS

PCT/US2014/069902

Compositions and Methods of Use of CRISPR-Cas Systems in Nucleotide Repeat Disorders

PCT/US2014/069897

Compositions and Methosd of Use of CRISPR-CAS Systems in Nucleotide Repeat Disorders

15/171,141

CRISPR-CAS Systems, Crystal Structure and Uses Thereof

15/349,603

Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications

15/467,949

Use and Production of CHD8+/- Transgenic Animals with Behavioral Phenotypes Characteristic of Autism Spectrum Disorder

15/469,081

Functional Screening with Optimized Functional CRISPR-Cas Systems

PCT/US2015/067177

CRISPR Having or Associated with

Destabilization Domains

PCT/US2015/065385

Protected Guide RNAs (PGRNAs)

15/632,067

RNA-Targeting System

PCT/US2015/067138

Unbiased Identification of Double- Strand Breaks and Genomic Rearrangement by Genome-Wide Insert Capture Sequencing

PCT/US2015/065393

Dead Guides for CRISPR Transcription Factors

15/619,735

Escorted and Functionalized Guides for CRISPR-CAS Systems

15/619,737

Delivery, Use and Therapeutic Applications of CRISPR Systems and Compositions for Genome Editing as to Hematopoietic Stem Cells (HSCs)

15/640,103

CRISPR MEDIATED IN VIVO MODELING AND GENETIC SCREENING OF TUMOR GROWTH AND METASTASIS

PCT/US2016/038252

Engineering and Optimization of Systems, Methods, Enzymes and Guide Scaffolds of CAS9 Orthologs and Variants for Sequence Manipulation

PCT/US2016/038034

CRISPR Enzyme Mutations Reducing Off-Target Effects

PCT/US2016/038205

CRISPR Mediated Recording of Cellular Events

PCT/US2017/047458

Novel CRISPR Enzymes and Systems

PCT/US2017/053795

Systematic Screening and Mapping of Regulatory Elements in Non-Coding Genomic Regions, Methods, Compositions, and Applications Thereof

62/502,064

62/564,102

Methods for Identification and Modification of LNCRNA Associated with Target Genotypes and Phenotypes

62/529,573

Methods for Designing Guides Sequences for Guided Nucleases

PCT/US2014/070068

CRISPR-CAS Systems and Methods for Altering Expression of Gene Products, Structural Information and Inducible Modular CAS Enzymes

PCT/US2014/041804

DELIVERY AND USE OF THE CRISPR- CAS SYSTEMS, VECTORS AND COMPOSITIONS FOR HEPATIC TARGETING AND THERAPY

PCT/US2014/070127

Delivery, Use and Therapeutic Applications of the CRISPR-Cas Systems and Compositions for Genomic Editing

PCT/US2014/041808

Delivery, Engineering and Optimization of Systems, Methods and Compositions for Targeting and Modeling Diseases and Disorders of Post Mitotic Cells

PCT/US2014/041809

Delivery, Use and therapeutic Applications of the CRISPR-Cas systems and Compositions for Targeting Disorders and Diseases Using Viral Components

PCT/US2014/070057

Delivery, Use and Therapeutic Applications of the CRISPR-CAS Systems and Compositions for Targeting Disorders and Diseases Using NanoParticle Components

PCT/US2013/074800

Functional Genomics Using CRISPR- CAS Systems, Compositions, Methods, Knock Out Libraries and Applications Thereof

PCT/US2014/070152

Engineering Of Systems, Methods And Optimized Guide Compositions with New Architectures For Sequence Manipulation

PCT/US2014/070175

Systems, Methods and Compositions for Sequence Manipulation with Optimized Functional CRISPR-CAS Systems

PCT/US2015/045504

Genome Editing Using CAS9 Nickases

15/467,888

Delivery, Use and Therapeutic Applications of the CRISPR-CAS Systems and Compositions for Modeling Competition of Multiple Cancer Mutations in Vivo


ERS Genomics Terms of Use

Abcam provides its modified cell lines that have been generated using CRISPR Cas9 technology under a license agreement with the ERS Genomics Limited ("ERS") that contains certain limitations and obligations.  By purchasing such modified cell lines, you, the buyer, hereby agree to use the modified cell lines for your own internal research only, and in accordance with the Terms of Use set out below:

BEFORE PLACING AN ORDER OR USING THIS PRODUCT, PLEASE READ THE TERMS AND CONDITIONS SET FORTH BELOW.  YOUR PURCHASE OF THIS PRODUCT SHALL CONSTITUTE ACKNOWLEDGMENT AND ACCEPTANCE OF THESE TERMS AND CONDITIONS.

Certain commercial entities and/or activities performed at commercial entities may require additional contract rights from ERS Genomics Limited which are not granted through the purchase of this product.  For additional information please see www.ersgenomics.com/research-products.php.

The buyer receives a non-exclusive, non-transferable right to use the Product, Progeny (meaning any unmodified descendant form of the Product), Modifications (meaning any modifications of the Product) and Unmodified Derivatives (meaning any substances created by the buyer which constitute an unmodified functional subunit or product expressed by the Product) for RESEARCH USE ONLY, which, subject to the exclusions below, includes use to discover and develop any product, including therapeutic products, which may then be sold to third parties, provided, however, that such products do not incorporate the Product, Progeny, Modifications, or Unmodified Derivatives.

No “Commercial Use” is allowed.  Commercial Use means any and all uses of the Product, Progeny, Modifications or Unmodified Derivatives thereof, or any modified cells or organisms created through use of the foregoing, including but not limited to:

(1)        Sale, whether or not such sale is limited for use in research;

(2)        Provision of a service to a third party;

(3)        Use in any diagnostic, preventative, or therapeutic application;

(4)        Use in any veterinary, livestock or agricultural application;

(5)        Use in later stage development of therapeutics, diagnostics, prophylactics (e.g., hit-to-lead, lead optimization); and

(6)        Manufacturing of a product for sale.

For clarity, transfer of materials or provision of services by not for profit or academic core labs to their internal clients shall not constitute a Commercial Use.

Except for the rights granted herein, any and all rights to the Product, Progeny, Modifications or Unmodified Derivatives thereof, shall remain in Abcam.  No ownership rights are transferred.

The buyer shall have no right to assign the rights granted herein to third parties.  The Product, Progeny, Modifications or Unmodified Derivatives thereof, must at all times remain in the possession of the buyer, except for a transfer to a scientific collaborator or to a service provider, to perform services, solely on behalf of the buyer.

ERS Genomics Limited is an intended third-party beneficiary under these Terms of Use.

ERS Genomics Limited Patent Rights (July 2019)

Granted Patents

Country

Application No.

Filing Date

Patent No.

Grant Date

AU

2013266968

15 Mar 2013

AU 2013266968 B2

07 Dec 2017

CN

201380038920.6

15 Mar 2013

CN 104854241 B

14 Jul 2017

EP

13793997.1

15 Mar 2013

EP 2800811 B1

10 May 2017

EP

17163434.8

15 Mar 2013

EP 3241902 B1

28 Feb 2018

EP

18152360.6

15 Mar 2013

EP 3401400 B1

03 Apr 2019

GB

1420270.9

15 Mar 2013

GB 2518764 C

02 Mar 2016

GB

1601071.2

15 Mar 2013

GB 2537000 B

08 Mar 2017

HK

15106335.4

03 Jul 2015

HK 1207107 B

25 Aug 2017

HK

15112610.8

23 Dec 2015

HK 1211978 B

04 May 2018

HK

17103002.1

03 Jul 2015

HK 1230233 B

01 Jun 2018

JP

20150514015

15 Mar 2013

JP 6343605 B

25 May 2018

MX

20140014477

15 Mar 2013

MX 349744 B

10 Aug 2017

NZ

714353

15 Mar 2013

NZ 714353 B2

29 Aug 2017

SG

11201407702

15 Mar 2013

SG 11201407702X

20 Mar 2017

SG

10201701800Y

15 Mar 2013

SG 10201701800Y

21 Nov 2018

TN

2014/0493

25 Nov 2014

TN 24223

03 Jun 2016

UA

A201413835

15 Mar 2013

UA 118014

12 Nov 2018

US

13/842,859

15 Mar 2013

US 10266850 B2

23 Apr 2019

US

14/685,502

13 Apr 2015

US 10000772 B2

19 Jun 2018

US

14/942,782

16 Nov 2015

US 10227611 B2

12 Mar 2019

US

15/138,604

26 Apr 2016

US 10113167 B2

30 Oct 2018

ZA

2014/07881

29 Oct 2014

ZA 2014/07881

31 Jan 2018

DE

2020132012240.4

15 Mar 2013

DE 202013012240 U1

02 Feb 2016

DE

2020132012241.2

15 Mar 2013

DE 202013012241 U1

18 Jan 2016

DE

2020132012242.0

15 Mar 2013

DE 202013012242 U1

02 Feb 2016






Patent Applications

Country

Application No.

Filing Date

Publication No.

Publication Date

PCT

PCT/US2013/032589

15 Mar 2013

WO 2013/176772 A1

28 Nov 2013

AE

P1296/2014

25 Nov 2014



AU

2017225060

07 Sep 2017

AU 2017225060 A1

28 Sep 2017

AU

2019201850

18 Mar 2019



BR

1120140294410

15 Mar 2013

BR 1120140294410 A2

27 Jun 2017

CA

2872241

15 Mar 2013

CA 2872241 A1

28 Nov 2013

CL

2014003208

25 Nov 2014

CL 2014003208 A1

19 Jun 2015

CN

201710585690.5

15 Mar 2013

CN 107603976 A

19 Jan 2018

CO

20140259531

25 Nov 2014

CO 7151523 A2

29 Dec 2014

CR

20140538

24 Nov 2014

CR 20140538 A

18 Feb 2015

DZ

140780

22 Dec 2014



EA

201401319

15 Mar 2013

EA 201401319 A1

29 May 2015

EC

IEPI-2014-28704

15 Mar 2013


30 Oct 2015

EG

PCT1887/2014

15 Mar 2013



EP

19157590.1

15 Mar 2013



GB

1511669.2

15 Mar 2013

GB 201511669 D0

19 Aug 2015

GE

AP2013013674

15 Mar 2013



HK

15104473.1

12 May 2015

HK 1204003 A1

06 Nov 2015

HK

19119875.3

22 Feb 2019



ID

P00201407783

10 Dec 2014

2016/03367

13 May 2016

IL

235461

15 Mar 2013


31 Dec 2014

IL

261563

15 Mar 2013


31 Oct 2018

IL

261565

15 Mar 2013


31 Oct 2018

IL

261566

15 Mar 2013


31 Oct 2018

IL

261567

15 Mar 2013


31 Oct 2018

IL

261568

15 Mar 2013


31 Oct 2018

IL

261569

15 Mar 2013


31 Oct 2018

IL

261570

15 Mar 2013


31 Oct 2018

IN

2995/KOLNP/2014

15 Mar 2013

2995/KOLNP/2014 A

04 Dec 2015

JP

2018-097369

21 May 2018

2018-138054

06 Sep 2018

KE

P/2014/002178

25 Nov 2014



KR

1020147036096

15 Mar 2013

KR 1020150016588 A

12 Feb 2015

KR

1020177034069

15 Mar 2013

KR 1020170134766 A

06 Dec 2017

KS

P/2017/000022

15 Mar 2013



LY

4958/2014

15 Mar 2013



MA

37663

15 Mar 2013

MA 37663 A1

31 May 2017

MX

2017010309

15 Mar 2013



MX

2019001995

15 Mar 2013



MY

PI2014003102

15 Mar 2013



MY

PI2018700285

15 Mar 2013



NZ

701326

15 Mar 2013



NZ

728024

15 Mar 2013

NZ 728024 A

27 Jan 2017

NZ

730667

15 Mar 2013

NZ 730667 A1

31 Mar 2017

OM

P/2014/00268

25 Nov 2014



PA

90441-01

25 Nov 2014


12 Sep 2016

PE

002211-2014/DIN

15 Mar 2013

PE 03362015 A1

25 Mar 2015

PH

12014502574

19 Nov 2014

PH 12014502574 A1

21 Jan 2015

QA

20141100400

15 Mar 2013



SG

10201809817U

15 Mar 2013

SG 10201809817U A

28 Dec 2018

SY

2014120156

15 Mar 2013



TH

1401007063

15 Mar 2013

TH 173084

15 Feb 2018

UA

A201808549

07 Aug 2018



US

61/652,086

25 May 2012



US

61/716,256

19 Oct 2012



US

61/757,640

28 Jan 2013



US

61/765,576

15 Feb 2013



US

14/403,475

24 Nov 2014

US 2016/0046961 A1

18 Feb 2016

US

14/685,504

13 Apr 2015

US 2016/0130609 A1

12 May 2016

US

14/685,513

13 Apr 2015

US 2016/0060653 A1

03 Mar 2016

US

14/685,514

13 Apr 2015

US 2016/0060654 A1

03 Mar 2016

US

14/685,516

13 Apr 2015

US 2016/0068864 A1

10 Mar 2016

US

15/090,511

04 Apr 2016

US 2017/0051312 A1

23 Feb 2017

US

15/343,156

03 Nov 2016



US

15/343,158

03 Nov 2016



US

15/435,233

16 Feb 2017

US 2017/0166893 A1

15 Jun 2017

US

15/803,424

03 Nov 2017

US 2018/0282764 A1

04 Oct 2018

US

15/915,020

07 Mar 2018

US 2019/0062790 A1

28 Feb 2019

US

15/925,544

19 Mar 2018

US 2018/0208931 A1

26 Jul 2018

US

15/947,680

06 Apr 2018

US 2018/0230495 A1

16 Aug 2018

US

15/947,700

06 Apr 2018

US 2018/0230496 A1

16 Aug 2018

US

15/947,718

06 Apr 2018

US 2018/0230497 A1

16 Aug 2018

US

15/959,715

23 Apr 2018

US 2018/0298406 A1

18 Oct 2018

US

15/959,735

23 Apr 2018

US 2018/0298407 A1

18 Oct 2018

US

15/959,762

23 Apr 2018

US 2018/0237801 A1

23 Aug 2018

US

15/959,782

23 Apr 2018

US 2018/0245100 A1

30 Aug 2018

US

15/959,802

23 Apr 2018

US 2018/0273981 A1

27 Sep 2018

US

15/965,598

27 Apr 2018

US 2018/0245101 A1

30 Aug 2018

US

15/965,603

27 Apr 2018

US 2018/0251791 A1

06 Sep 2018

US

15/981,807

16 May 2018

US 2018/0251793 A1

06 Sep 2018

US

15/981,808

16 May 2018

US 2018/0251794 A1

06 Sep 2018

US

15/981,809

16 May 2018

US 2018/0251795 A1

06 Sep 2018

US

16/033,002

11 Jul 2018

US 2018/0312874 A1

01 Nov 2018

US

16/033,005

11 Jul 2018

US 2018/0312875 A1

01 Nov 2018

US

16/033,016

11 Jul 2018

US 2018/0312876 A1

01 Nov 2018

US

16/136,159

19 Sep 2018

US 2019/0002921 A1

03 Jan 2019

US

16/136,165

19 Sep 2018

US 2019/0002922 A1

03 Jan 2019

US

16/136,168

19 Sep 2018

US 2019/0002923 A1

03 Jan 2019

US

16/136,175

19 Sep 2018

US 2019/0010520 A1

10 Jan 2019

US

16/201,836

27 Nov 2018

US 2019/0093129 A1

28 Mar 2019

US

16/201,848

27 Nov 2018

US 2019/0106711 A1

11 Apr 2019

US

16/201,853

27 Nov 2018

US 2019/0106712 A1

11 Apr 2019

US

16/201,855

27 Nov 2018

US 2019/0106713 A1

11 Apr 2019

US

16/201,862

27 Nov 2018

US 2019/0106714 A1

11 Apr 2019

US

16/201,865

27 Nov 2018

US 2019/0106715 A1

11 Apr 2019

US

16/276,343

14 Feb 2019



US

16/276,348

14 Feb 2019



US

16/276,352

14 Feb 2019



US

16/276,356

14 Feb 2019



US

16/276,361

14 Feb 2019



US

16/276,365

14 Feb 2019



US

16/276,368

14 Feb 2019



US

16/276,374

14 Feb 2019



US

16/277,090

15 Feb 2019



US

16/380,758

10 Apr 2019



US

16/380,781

10 Apr 2019



US

16/382,093

11 Apr 2019



US

16/382,096

11 Apr 2019



US

16/382,097

11 Apr 2019



US

16/382,100

11 Apr 2019



US

16/383,412

12 Apr 2019



US

16/383,422

12 Apr 2019



US

16/383,433

12 Apr 2019



US

16/383,443

12 Apr 2019



US

16/385,360

16 Apr 2019



US

16/385,383

16 Apr 2019



UZ

IAP20140559

15 Mar 2013



VN

1-2014-04335

15 Mar 2013



ZA

2017/00720

30 Jan 2017




Sigma-Aldrich CRISPR Use License Agreement


Abcam provides its modified cell lines that have been generated using CRISPR technology under a license agreement with Sigma-Aldrich Co. LLC. (“Sigma”) that contains certain limitations and obligations.  By purchasing such modified cell lines, you, (the “Buyer”), hereby agree to use the modified cell lines for your own internal research only, and in accordance with the CRISPR Use License Agreement (“License Agreement”) set out below:

This Product and its use are the subject of one or more of the following patents and applications controlled by Sigma: Patent applications and issued patents that entered their respective National Stage from PCT International Pub. No. WO 2014/089290, including, but not limited to, the following, and substitutions, divisions, continuations, continuations-in-part, reissues, reexaminations, and extensions thereof: Australia Patent Nos. 2013355214;  2017204031; and  2018229489;  Canada Patent  No.  2,891,347; China Patent No. CN105142669; European Patent Nos. EP 3 138 910 B1, 3 138 911 B1, and EP 3 138 912 B1; Israel Patent No. IL238856; Singapore Patent No. 11201503824S; South Korea Patent No. 10- 1844123; and U.S. Patent Application Serial Nos. 15/188,911; 15/188,924; 15/188,927; 15/188,931; and 15/456,204 (the “Patent Rights”).

BEFORE OPENING OR USING THIS PRODUCT, PLEASE READ THE TERMS AND CONDITIONS SET FORTH IN THIS LICENSE AGREEMENT. YOUR USE OF THIS PRODUCT SHALL CONSTITUTE ACKNOWLEDGMENT AND ACCEPTANCE OF THESE TERMS AND CONDITIONS.

The purchase of this Product conveys to you, the Buyer, the NON-TRANSFERABLE right to use the purchased Product for Licensed Research Use (see definition below) subject to the conditions set out in this License Agreement. If you wish to use this Product for any purpose other than Licensed Research Use, you must first obtain an appropriate license (see information set out below).

This Product may not be used for any purpose other than Licensed Research Use. Your right to use this Product for Licensed Research Use is subject to the following conditions and restrictions:

  1. Licensed Research Use means any use for research purposes, with the following exceptions: 

i. Buyer may not sell or otherwise transfer the Product (including without limitation any material that contains the Product in whole or part) or any Related Material to any other third party (except that you may transfer the Product, including without limitation any material that contains the Product in whole or in part, or any Related Material to a bona fide collaborator or contract research person or entity), or use the Products or any Related Material to perform services for the benefit of any other person or entity;

ii. Buyer may use only the purchased amount of the Product and components of the Product, and shall use any Related Material, only for your internal research within the Field, and not for any Commercial Purposes;

iii. Buyer shall use the Product and any Related Material in compliance with all applicable laws and regulations, including without limitation applicable human health and animal welfare laws and regulations;

iv. Sigma shall provide no warranties of any kind to the Buyer (statutory or implied) concerning the Patent Rights, the Product or any Related Materials, including without limitation, as to product quality, condition, description, merchantability, fitness for a particular purpose, noninfringement of intellectual property rights or the absence of latent or other defects, and all such warranties are hereby expressly disclaimed;

v. Sigma shall expressly disclaim any warranty regarding results obtained through the use of the Product or Related Materials, including without limitation any claim of inaccurate, invalid or incomplete results;

vi. Sigma, and their directors, officers, employees and agents, shall have no liability to the Buyer, including, without limitation, for any loss of use or profits, business interruption or any consequential, incidental, special or other indirect damages of any kind, regardless of how caused and regardless of whether an action in contract, tort, strict product liability or otherwise;

vii. the Buyer shall indemnify, defend, and hold harmless Sigma and their current and former directors, officers, employees and agents, and their respective successors, heirs and assigns (the Indemnities) against any liability, damage, loss, or expense (including without limitation reasonable attorneys’ fees and expenses) incurred by or imposed upon any of the Indemnitees in connection with any claims, suits, investigations, actions, demands or judgments arising out of or related to the exercise of any rights granted to the Buyer hereunder or any breach of this License Agreement by such Buyer; and

viii. the Product and its use may be the subject of one or more issued patents and/or pending patent applications owned by Sigma and the purchase of the Product does not convey a license under any claims in the foregoing patents or patent applications directed to the Licensed Product or use, production or commercialization thereof.


For purposes of Section 1 above, the following definitions shallapply:

Commercial Purposes means (a) the practice, performance or provision of any method, process or service, or (b) the manufacture, sale, use, distribution, disposition or importing of any product, in each case (a) or (b) for consideration, e.g., a fee, or on any other commercial basis.

Field means use as a research tool for research purposes; provided, however, that notwithstanding the foregoing, the Field shall expressly exclude (a) any in vivo and ex vivo human or clinical use, including, without limitation, any administration into humans or any diagnostic or prognostic use, (b) the creation of transgenic rodent models and/or derivatives thereof (including, but not limited to, rodents’ cells and rodents’ organs) by for-profit entities, (c) any in vivo veterinary or livestock use, or non-research agricultural use, or (d) the manufacture, distribution, importation, exportation, transportation, sale, offer for sale, marketing, promotion or other exploitation or use of, or as, a testing service, therapeutic or diagnostic for humans or animals.


Related Materials means any progeny, modification or derivative of a Product.

2. Your right to use the Product will terminate immediately if you fail to comply with these terms and conditions. You shall, upon such termination of your rights, destroy all Product, Related Materials, and components thereof in your control, and notify Sigma of such in writing. For information on purchasing a license to this Product for purposes other than Licensed Research Use, contact your local Sigma sales representative, who will refer you to the proper licensing representative, or in the USA call 800-325-3010.

Sigma-Aldrich Patent Rights:

Patent applications and issued patents that entered their respective National Stage from PCT International Pub. No. WO 2014/089290









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