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Limited use licenses

Related

  • Licensed patent rights


    Contents

    • Broad Institute limited license
    • ERS Genomics terms of use
    • Sigma-Aldrich CRISPR Use License Agreement
    • Limited Use Licenses for ioNEURONS/glut - Glutamatergic Neurons

    ​

    Broad Institute Limited License

    Abcam provides its modified cell lines that have been generated using CRISPR Cas9 technology under a license agreement with the Broad Institute, Inc. ("Broad") that contains certain limitations and obligations.  By purchasing such modified cell lines, you, (the “Buyer”), hereby agree to use the modified cell lines for your own internal research only, and in accordance with the Limited License below:

    1. the Buyer shall not sell or otherwise transfer Products (including without limitation any material that contains a Product in whole or in part) to any other person or entity except (1) as otherwise permitted under license to Buyer from Broad or as otherwise permitted by Broad for non-profit use, as provided at https://www.broadinstitute.org/partnerships/office-strategic-alliances-and-partnering/information-about-licensing-crispr-genome-edi or (2) to a Third Party contract organization to the extent such Third Party contract organization (A) provides the service of generating only information or data on behalf of a Limited Licensee through the use of the Products, (B) does not otherwise make use of the Patent Rights in providing such services to such Limited Licenses.
    2. the Buyer shall use only the purchased amount of the Products purchased from Company, and shall use Products and components of the Products only for its internal research within the Field, which may include internal research within the Field in connection with product research, but not for the production, manufacture or exploitation of any product or Product or any Commercial Purposes
    3. the Buyer shall use Products in compliance with all applicable laws and regulations, including without limitation applicable human health and animal welfare laws and regulations
    4. the Licensor Parties shall provide no warranties of any kind to the Buyer (statutory or implied) concerning the Patent Rights or Products, including without limitation, as to product quality, condition, description, merchantability, fitness for a particular purpose, non-infringement of intellectual property rights or the absence of latent or other defects, and all such warranties are hereby expressly disclaimed
    5. the Licensor Parties shall expressly disclaim any warranty regarding results obtained through the use of the Products, including without limitation any claim of inaccurate, invalid or incomplete results
    6. the Licensor Parties and their directors, trustees, officers, employees, agents, faculty, affiliated investigators, and students, shall have no liability to the Buyer, including, without limitation, for any loss of use or profits, business interruption or any consequential, incidental, special or other indirect damages of any kind, regardless of how caused and regardless of whether an action in contract, tort, strict product liability or otherwise
    7. the Buyer shall indemnify, defend and hold harmless the Indemnitees against any liability, incurred by or imposed upon any of the Indemnitees, as applicable, in connection with any claims, suits, investigations, actions, demands or judgments arising out of or related to the exercise of any rights granted to the Buyer under the Limited License or any breach of the Limited License by such Buyer, provided that, to the extent the foregoing is not permitted by law, the Buyer agrees, to the extent permitted by law, that it, and not the Indemnitees, as applicable, shall be responsible for any liability, damage, loss or expense arising out of or related to the exercise of any rights granted to the Buyer under the Limited License or any breach of the Limited License by Buyer
    8. the Product and its use may be the subject of one or more issued patents or pending patent applications owned by one or more Licensor Parties and the purchase of the Product does not convey a license under any claims in the foregoing patents or patent applications directed to the Product or use, production or commercialization thereof, except as expressly set forth in the Limited License
    9. this Limited License does not contain any restrictions on the use of Products by non-profit institutions other than those set forth in the foregoing clauses (1) – (8), including without limitation, any reach-through rights (including without limitation any right to receive payment) with respect to products or discoveries made, discovered, derived, identified or selected using such Products.
    10. nothing in this Limited License shall be construed to confer any rights upon Buyer by implication, estoppel, or otherwise as to any technology or patent rights of any entity other than the Patent Rights.  In addition, nothing in this Limited License shall be construed to confer upon Buyer or any Third Party any rights under or to the Patent Rights outside of the Field.

    The following definitions apply to the Limited License:


    Commercial Purposes means (a) the practice, performance or provision of any method, process or service, or (b) the manufacture, production, sale, use, distribution, disposition or importing of any product, in each case (a) or (b) for consideration of any kind, for the purpose of sale or commercial exploitation, or on any other commercial basis.

    Company means Abcam plc.

    Enabled Product means any product, that is not the Licensed Product, which is or incorporates (a) any progeny, modification or derivative of the Licensed Product, or (b) any cell, organism or animal made or modified through use of the Licensed Product, or any progeny, modification or derivative of such cell, organism or animal.  For clarity, any product that is made, produced or derived by use of the technology of the Patent Rights, such as a protein or a peptide from a cell line shall be deemed an Enabled Product; provided, however, that the term Enabled Product shall not include any large or small molecule that(i) was identified or discovered through screening using technology covered by the Patent Rights and (ii) does not otherwise fall within the foregoing clauses (a) through (b).


    Field means use as a research tool for research purposes; provided, however, that notwithstanding the foregoing, the Field shall expressly exclude (a) any clinical use, including, without limitation, diagnostic and prognostic use,(b) any human, veterinary, livestock or agricultural use, or (c) the manufacture, distribution, importation, exportation, transportation, sale, offer for sale, marketing, promotion or other exploitation or use of, or as, a testing service, therapeutic or diagnostic for humans or animals.


    Indemnitees means each Licensor Party, their affiliates, and their current and former trustees, directors, officers, faculty, affiliated investigators, students, employees, medical and professional staff and agents and their respective successors, heirs and assigns


    Licensed Patent Rights means (a) any patents and patent applications listed in the Broad Institute Patent Rights table below; (b) any substitutions, divisions, continuations, reissues, renewals, re-examinations or extensions of any patents or patent applications of (a), any continuations-in-part of any patents or patent applications of (a) to the extent the claims are directed to subject matter specifically described in a patent or patent application set forth on Appendix A, and any application claiming priority to a provisional application listed in the Broad Institute Patent Rights table below, to the extent the claims are directed to subject matter specifically described in a provisional patent application set forth on Appendix A; (c) any letters patents and/or the equivalent issuing therefrom in any jurisdiction based on any of the foregoing; and (d) any foreign or international equivalents of any of the foregoing, including without limitation any applications filed under the Patent Cooperation Treaty.


    Licensor Parties means the Broad Institute, Inc.; the President and Fellows of Harvard College, Massachusetts Institute of Technology, University of Iowa Research Foundation; University of Tokyo; Rockefeller University; New York University, New York Genome Center.


    Product means any product (a) that is Covered by at least one Claim of the Patent Rights or (b) that is not described in the foregoing clause (a) but that includes, uses, is derived from or is developed, identified or made through the use of technology Covered by at least one Claim of the Patent Rights or a product covered by the foregoing clause (a) (including any biological material, cell, organism or animal so derived, developed, identified or made) and any progeny, modifications, improvements or derivatives thereof; provided, however, that the term “Product” shall not include (A) any therapeutic large or small molecule that (i) was identified through screening using the technology Covered by the Patent Rights and (ii) does not otherwise make use of the Patent Rights or (B) any product that would not otherwise be a Product except for the use of a Product, Process or the technology Covered by at least one Claim of the Patent Rights solely for purposes of Company’s internal quality control or validation.



    Broad Institute Patent Rights

    EXEMPLARY FAMILY SERIAL NO

    PATENT TITLE

    PCT/US2013/074611

    CRISPR-CAS Component Systems, thods and Compositions for Sequence Manipulation

    PCT/US2013/074743

    CRISPR-CAS Systems and Methods for Altering Expressions of Gene Products

    14/259,420

    CRISPR-CAS Systems, Methods and Compositions For Sequence Manipulation in Eukaryotes

    PCT/US2013/051418

    Inducible DNA Binding Proteins and Genome Perturbation Tools and Applications Thereof

    PCT/US2013/074825

    Methods, Systems and Apparatus for Identifying Target Seuqences for CAS Enzymes or CRISPR-CAS Systems for Target Sequences and Conveying Results Thereof

    PCT/US2013/074812

    Methods, Models, Systems and Apparatus for Identifying Target Sequences for CAS Enzymes or CRISPR-CAS Systems for Target Sequences and Conveying Results Thereof

    PCT/US2013/074667

    Delivery, Engineering and Optimization of Systems Methods and Compositions for Sequence Manipulation and Therapeutic Applications

    PCT/US2014/041803

    Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Applications

    PCT/US2013/074691

    Engineering and Optimization of Improved Systems, Methods and Enzyme Compositions for Sequence Manipulation

    PCT/US2013/074736

    Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation with Functional Domains

    PCT/US2013/074819

    Engineering of Systems, Methods and Optimized Guide Compositions for Sequence Manipulation

    14/855,046

    Recombinant Virus And Preparations Thereof

    PCT/US2014/041800

    Delivery, Engineering and Optimization of Tandem Guide Systems, Methods and Compositions for Sequence Manipulation

    PCT/US2014/041806

    Fiunctional Genomics Using CRISPR-Cas Systems, Compositions, Methods, Screens and Applications Thereof

    PCT/US2014/064663

    CRISPR-Related Methods and Compositions with Governing gRNAS

    PCT/US2014/069902

    Compositions and Methods of Use of CRISPR-Cas Systems in Nucleotide Repeat Disorders

    PCT/US2014/069897

    Compositions and Methosd of Use of CRISPR-CAS Systems in Nucleotide Repeat Disorders

    15/171,141

    CRISPR-CAS Systems, Crystal Structure and Uses Thereof

    15/349,603

    Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications

    15/467,949

    Use and Production of CHD8+/- Transgenic Animals with Behavioral Phenotypes Characteristic of Autism Spectrum Disorder

    15/469,081

    Functional Screening with Optimized Functional CRISPR-Cas Systems

    PCT/US2015/067177

    CRISPR Having or Associated with

    Destabilization Domains

    PCT/US2015/065385

    Protected Guide RNAs (PGRNAs)

    15/632,067

    RNA-Targeting System

    PCT/US2015/067138

    Unbiased Identification of Double- Strand Breaks and Genomic Rearrangement by Genome-Wide Insert Capture Sequencing

    PCT/US2015/065393

    Dead Guides for CRISPR Transcription Factors

    15/619,735

    Escorted and Functionalized Guides for CRISPR-CAS Systems

    15/619,737

    Delivery, Use and Therapeutic Applications of CRISPR Systems and Compositions for Genome Editing as to Hematopoietic Stem Cells (HSCs)

    15/640,103

    CRISPR MEDIATED IN VIVO MODELING AND GENETIC SCREENING OF TUMOR GROWTH AND METASTASIS

    PCT/US2016/038252

    Engineering and Optimization of Systems, Methods, Enzymes and Guide Scaffolds of CAS9 Orthologs and Variants for Sequence Manipulation

    PCT/US2016/038034

    CRISPR Enzyme Mutations Reducing Off-Target Effects

    PCT/US2016/038205

    CRISPR Mediated Recording of Cellular Events

    PCT/US2017/047458

    Novel CRISPR Enzymes and Systems

    PCT/US2017/053795

    Systematic Screening and Mapping of Regulatory Elements in Non-Coding Genomic Regions, Methods, Compositions, and Applications Thereof

    62/502,064

    62/564,102

    Methods for Identification and Modification of LNCRNA Associated with Target Genotypes and Phenotypes

    62/529,573

    Methods for Designing Guides Sequences for Guided Nucleases

    PCT/US2014/070068

    CRISPR-CAS Systems and Methods for Altering Expression of Gene Products, Structural Information and Inducible Modular CAS Enzymes

    PCT/US2014/041804

    DELIVERY AND USE OF THE CRISPR- CAS SYSTEMS, VECTORS AND COMPOSITIONS FOR HEPATIC TARGETING AND THERAPY

    PCT/US2014/070127

    Delivery, Use and Therapeutic Applications of the CRISPR-Cas Systems and Compositions for Genomic Editing

    PCT/US2014/041808

    Delivery, Engineering and Optimization of Systems, Methods and Compositions for Targeting and Modeling Diseases and Disorders of Post Mitotic Cells

    PCT/US2014/041809

    Delivery, Use and therapeutic Applications of the CRISPR-Cas systems and Compositions for Targeting Disorders and Diseases Using Viral Components

    PCT/US2014/070057

    Delivery, Use and Therapeutic Applications of the CRISPR-CAS Systems and Compositions for Targeting Disorders and Diseases Using NanoParticle Components

    PCT/US2013/074800

    Functional Genomics Using CRISPR- CAS Systems, Compositions, Methods, Knock Out Libraries and Applications Thereof

    PCT/US2014/070152

    Engineering Of Systems, Methods And Optimized Guide Compositions with New Architectures For Sequence Manipulation

    PCT/US2014/070175

    Systems, Methods and Compositions for Sequence Manipulation with Optimized Functional CRISPR-CAS Systems

    PCT/US2015/045504

    Genome Editing Using CAS9 Nickases

    15/467,888

    Delivery, Use and Therapeutic Applications of the CRISPR-CAS Systems and Compositions for Modeling Competition of Multiple Cancer Mutations in Vivo

    ​


    ERS Genomics Terms of Use

    Abcam provides its modified cell lines that have been generated using CRISPR Cas9 technology under a license agreement with the ERS Genomics Limited ("ERS") that contains certain limitations and obligations.  By purchasing such modified cell lines, you, the buyer, hereby agree to use the modified cell lines for your own internal research only, and in accordance with the Terms of Use set out below:

    BEFORE PLACING AN ORDER OR USING THIS PRODUCT, PLEASE READ THE TERMS AND CONDITIONS SET FORTH BELOW.  YOUR PURCHASE OF THIS PRODUCT SHALL CONSTITUTE ACKNOWLEDGMENT AND ACCEPTANCE OF THESE TERMS AND CONDITIONS.

    Certain commercial entities and/or activities performed at commercial entities may require additional contract rights from ERS Genomics Limited which are not granted through the purchase of this product.  For additional information please see www.ersgenomics.com/research-products.php.

    The buyer receives a non-exclusive, non-transferable right to use the Product, Progeny (meaning any unmodified descendant form of the Product), Modifications (meaning any modifications of the Product) and Unmodified Derivatives (meaning any substances created by the buyer which constitute an unmodified functional subunit or product expressed by the Product) for RESEARCH USE ONLY, which, subject to the exclusions below, includes use to discover and develop any product, including therapeutic products, which may then be sold to third parties, provided, however, that such products do not incorporate the Product, Progeny, Modifications, or Unmodified Derivatives.

    No “Commercial Use” is allowed.  Commercial Use means any and all uses of the Product, Progeny, Modifications or Unmodified Derivatives thereof, or any modified cells or organisms created through use of the foregoing, including but not limited to:

    (1)        Sale, whether or not such sale is limited for use in research;

    (2)        Provision of a service to a third party;

    (3)        Use in any diagnostic, preventative, or therapeutic application;

    (4)        Use in any veterinary, livestock or agricultural application;

    (5)        Use in later stage development of therapeutics, diagnostics, prophylactics (e.g., hit-to-lead, lead optimization); and

    ​(6)        Manufacturing of a product for sale.

    For clarity, transfer of materials or provision of services by not for profit or academic core labs to their internal clients shall not constitute a Commercial Use.

    Except for the rights granted herein, any and all rights to the Product, Progeny, Modifications or Unmodified Derivatives thereof, shall remain in Abcam.  No ownership rights are transferred.

    The buyer shall have no right to assign the rights granted herein to third parties.  The Product, Progeny, Modifications or Unmodified Derivatives thereof, must at all times remain in the possession of the buyer, except for a transfer to a scientific collaborator or to a service provider, to perform services, solely on behalf of the buyer.

    ERS Genomics Limited is an intended third-party beneficiary under these Terms of Use.

    ERS Genomics Limited Patent Rights (July 2019)

    Granted Patents

    Country

    Application No.

    Filing Date

    Patent No.

    Grant Date

    AU

    2013266968

    15 Mar 2013

    AU 2013266968 B2

    07 Dec 2017

    CN

    201380038920.6

    15 Mar 2013

    CN 104854241 B

    14 Jul 2017

    EP

    13793997.1

    15 Mar 2013

    EP 2800811 B1

    10 May 2017

    EP

    17163434.8

    15 Mar 2013

    EP 3241902 B1

    28 Feb 2018

    EP

    18152360.6

    15 Mar 2013

    EP 3401400 B1

    03 Apr 2019

    GB

    1420270.9

    15 Mar 2013

    GB 2518764 C

    02 Mar 2016

    GB

    1601071.2

    15 Mar 2013

    GB 2537000 B

    08 Mar 2017

    HK

    15106335.4

    03 Jul 2015

    HK 1207107 B

    25 Aug 2017

    HK

    15112610.8

    23 Dec 2015

    HK 1211978 B

    04 May 2018

    HK

    17103002.1

    03 Jul 2015

    HK 1230233 B

    01 Jun 2018

    JP

    20150514015

    15 Mar 2013

    JP 6343605 B

    25 May 2018

    MX

    20140014477

    15 Mar 2013

    MX 349744 B

    10 Aug 2017

    NZ

    714353

    15 Mar 2013

    NZ 714353 B2

    29 Aug 2017

    SG

    11201407702

    15 Mar 2013

    SG 11201407702X

    20 Mar 2017

    SG

    10201701800Y

    15 Mar 2013

    SG 10201701800Y

    21 Nov 2018

    TN

    2014/0493

    25 Nov 2014

    TN 24223

    03 Jun 2016

    UA

    A201413835

    15 Mar 2013

    UA 118014

    12 Nov 2018

    US

    13/842,859

    15 Mar 2013

    US 10266850 B2

    23 Apr 2019

    US

    14/685,502

    13 Apr 2015

    US 10000772 B2

    19 Jun 2018

    US

    14/942,782

    16 Nov 2015

    US 10227611 B2

    12 Mar 2019

    US

    15/138,604

    26 Apr 2016

    US 10113167 B2

    30 Oct 2018

    ZA

    2014/07881

    29 Oct 2014

    ZA 2014/07881

    31 Jan 2018

    DE

    2020132012240.4

    15 Mar 2013

    DE 202013012240 U1

    02 Feb 2016

    DE

    2020132012241.2

    15 Mar 2013

    DE 202013012241 U1

    18 Jan 2016

    DE

    2020132012242.0

    15 Mar 2013

    DE 202013012242 U1

    02 Feb 2016






    Patent Applications

    Country

    Application No.

    Filing Date

    Publication No.

    Publication Date

    PCT

    PCT/US2013/032589

    15 Mar 2013

    WO 2013/176772 A1

    28 Nov 2013

    AE

    P1296/2014

    25 Nov 2014



    AU

    2017225060

    07 Sep 2017

    AU 2017225060 A1

    28 Sep 2017

    AU

    2019201850

    18 Mar 2019



    BR

    1120140294410

    15 Mar 2013

    BR 1120140294410 A2

    27 Jun 2017

    CA

    2872241

    15 Mar 2013

    CA 2872241 A1

    28 Nov 2013

    CL

    2014003208

    25 Nov 2014

    CL 2014003208 A1

    19 Jun 2015

    CN

    201710585690.5

    15 Mar 2013

    CN 107603976 A

    19 Jan 2018

    CO

    20140259531

    25 Nov 2014

    CO 7151523 A2

    29 Dec 2014

    CR

    20140538

    24 Nov 2014

    CR 20140538 A

    18 Feb 2015

    DZ

    140780

    22 Dec 2014



    EA

    201401319

    15 Mar 2013

    EA 201401319 A1

    29 May 2015

    EC

    IEPI-2014-28704

    15 Mar 2013


    30 Oct 2015

    EG

    PCT1887/2014

    15 Mar 2013



    EP

    19157590.1

    15 Mar 2013



    GB

    1511669.2

    15 Mar 2013

    GB 201511669 D0

    19 Aug 2015

    GE

    AP2013013674

    15 Mar 2013



    HK

    15104473.1

    12 May 2015

    HK 1204003 A1

    06 Nov 2015

    HK

    19119875.3

    22 Feb 2019



    ID

    P00201407783

    10 Dec 2014

    2016/03367

    13 May 2016

    IL

    235461

    15 Mar 2013


    31 Dec 2014

    IL

    261563

    15 Mar 2013


    31 Oct 2018

    IL

    261565

    15 Mar 2013


    31 Oct 2018

    IL

    261566

    15 Mar 2013


    31 Oct 2018

    IL

    261567

    15 Mar 2013


    31 Oct 2018

    IL

    261568

    15 Mar 2013


    31 Oct 2018

    IL

    261569

    15 Mar 2013


    31 Oct 2018

    IL

    261570

    15 Mar 2013


    31 Oct 2018

    IN

    2995/KOLNP/2014

    15 Mar 2013

    2995/KOLNP/2014 A

    04 Dec 2015

    JP

    2018-097369

    21 May 2018

    2018-138054

    06 Sep 2018

    KE

    P/2014/002178

    25 Nov 2014



    KR

    1020147036096

    15 Mar 2013

    KR 1020150016588 A

    12 Feb 2015

    KR

    1020177034069

    15 Mar 2013

    KR 1020170134766 A

    06 Dec 2017

    KS

    P/2017/000022

    15 Mar 2013



    LY

    4958/2014

    15 Mar 2013



    MA

    37663

    15 Mar 2013

    MA 37663 A1

    31 May 2017

    MX

    2017010309

    15 Mar 2013



    MX

    2019001995

    15 Mar 2013



    MY

    PI2014003102

    15 Mar 2013



    MY

    PI2018700285

    15 Mar 2013



    NZ

    701326

    15 Mar 2013



    NZ

    728024

    15 Mar 2013

    NZ 728024 A

    27 Jan 2017

    NZ

    730667

    15 Mar 2013

    NZ 730667 A1

    31 Mar 2017

    OM

    P/2014/00268

    25 Nov 2014



    PA

    90441-01

    25 Nov 2014


    12 Sep 2016

    PE

    002211-2014/DIN

    15 Mar 2013

    PE 03362015 A1

    25 Mar 2015

    PH

    12014502574

    19 Nov 2014

    PH 12014502574 A1

    21 Jan 2015

    QA

    20141100400

    15 Mar 2013



    SG

    10201809817U

    15 Mar 2013

    SG 10201809817U A

    28 Dec 2018

    SY

    2014120156

    15 Mar 2013



    TH

    1401007063

    15 Mar 2013

    TH 173084

    15 Feb 2018

    UA

    A201808549

    07 Aug 2018



    US

    61/652,086

    25 May 2012



    US

    61/716,256

    19 Oct 2012



    US

    61/757,640

    28 Jan 2013



    US

    61/765,576

    15 Feb 2013



    US

    14/403,475

    24 Nov 2014

    US 2016/0046961 A1

    18 Feb 2016

    US

    14/685,504

    13 Apr 2015

    US 2016/0130609 A1

    12 May 2016

    US

    14/685,513

    13 Apr 2015

    US 2016/0060653 A1

    03 Mar 2016

    US

    14/685,514

    13 Apr 2015

    US 2016/0060654 A1

    03 Mar 2016

    US

    14/685,516

    13 Apr 2015

    US 2016/0068864 A1

    10 Mar 2016

    US

    15/090,511

    04 Apr 2016

    US 2017/0051312 A1

    23 Feb 2017

    US

    15/343,156

    03 Nov 2016



    US

    15/343,158

    03 Nov 2016



    US

    15/435,233

    16 Feb 2017

    US 2017/0166893 A1

    15 Jun 2017

    US

    15/803,424

    03 Nov 2017

    US 2018/0282764 A1

    04 Oct 2018

    US

    15/915,020

    07 Mar 2018

    US 2019/0062790 A1

    28 Feb 2019

    US

    15/925,544

    19 Mar 2018

    US 2018/0208931 A1

    26 Jul 2018

    US

    15/947,680

    06 Apr 2018

    US 2018/0230495 A1

    16 Aug 2018

    US

    15/947,700

    06 Apr 2018

    US 2018/0230496 A1

    16 Aug 2018

    US

    15/947,718

    06 Apr 2018

    US 2018/0230497 A1

    16 Aug 2018

    US

    15/959,715

    23 Apr 2018

    US 2018/0298406 A1

    18 Oct 2018

    US

    15/959,735

    23 Apr 2018

    US 2018/0298407 A1

    18 Oct 2018

    US

    15/959,762

    23 Apr 2018

    US 2018/0237801 A1

    23 Aug 2018

    US

    15/959,782

    23 Apr 2018

    US 2018/0245100 A1

    30 Aug 2018

    US

    15/959,802

    23 Apr 2018

    US 2018/0273981 A1

    27 Sep 2018

    US

    15/965,598

    27 Apr 2018

    US 2018/0245101 A1

    30 Aug 2018

    US

    15/965,603

    27 Apr 2018

    US 2018/0251791 A1

    06 Sep 2018

    US

    15/981,807

    16 May 2018

    US 2018/0251793 A1

    06 Sep 2018

    US

    15/981,808

    16 May 2018

    US 2018/0251794 A1

    06 Sep 2018

    US

    15/981,809

    16 May 2018

    US 2018/0251795 A1

    06 Sep 2018

    US

    16/033,002

    11 Jul 2018

    US 2018/0312874 A1

    01 Nov 2018

    US

    16/033,005

    11 Jul 2018

    US 2018/0312875 A1

    01 Nov 2018

    US

    16/033,016

    11 Jul 2018

    US 2018/0312876 A1

    01 Nov 2018

    US

    16/136,159

    19 Sep 2018

    US 2019/0002921 A1

    03 Jan 2019

    US

    16/136,165

    19 Sep 2018

    US 2019/0002922 A1

    03 Jan 2019

    US

    16/136,168

    19 Sep 2018

    US 2019/0002923 A1

    03 Jan 2019

    US

    16/136,175

    19 Sep 2018

    US 2019/0010520 A1

    10 Jan 2019

    US

    16/201,836

    27 Nov 2018

    US 2019/0093129 A1

    28 Mar 2019

    US

    16/201,848

    27 Nov 2018

    US 2019/0106711 A1

    11 Apr 2019

    US

    16/201,853

    27 Nov 2018

    US 2019/0106712 A1

    11 Apr 2019

    US

    16/201,855

    27 Nov 2018

    US 2019/0106713 A1

    11 Apr 2019

    US

    16/201,862

    27 Nov 2018

    US 2019/0106714 A1

    11 Apr 2019

    US

    16/201,865

    27 Nov 2018

    US 2019/0106715 A1

    11 Apr 2019

    US

    16/276,343

    14 Feb 2019



    US

    16/276,348

    14 Feb 2019



    US

    16/276,352

    14 Feb 2019



    US

    16/276,356

    14 Feb 2019



    US

    16/276,361

    14 Feb 2019



    US

    16/276,365

    14 Feb 2019



    US

    16/276,368

    14 Feb 2019



    US

    16/276,374

    14 Feb 2019



    US

    16/277,090

    15 Feb 2019



    US

    16/380,758

    10 Apr 2019



    US

    16/380,781

    10 Apr 2019



    US

    16/382,093

    11 Apr 2019



    US

    16/382,096

    11 Apr 2019



    US

    16/382,097

    11 Apr 2019



    US

    16/382,100

    11 Apr 2019



    US

    16/383,412

    12 Apr 2019



    US

    16/383,422

    12 Apr 2019



    US

    16/383,433

    12 Apr 2019



    US

    16/383,443

    12 Apr 2019



    US

    16/385,360

    16 Apr 2019



    US

    16/385,383

    16 Apr 2019



    UZ

    IAP20140559

    15 Mar 2013



    VN

    1-2014-04335

    15 Mar 2013



    ZA

    2017/00720

    30 Jan 2017




    Sigma-Aldrich CRISPR Use License Agreement


    Abcam provides its modified cell lines that have been generated using CRISPR technology under a license agreement with Sigma-Aldrich Co. LLC. (“Sigma”) that contains certain limitations and obligations.  By purchasing such modified cell lines, you, (the “Buyer”), hereby agree to use the modified cell lines for your own internal research only, and in accordance with the CRISPR Use License Agreement (“License Agreement”) set out below:

    This Product and its use are the subject of one or more of the following patents and applications controlled by Sigma: Patent applications and issued patents that entered their respective National Stage from PCT International Pub. No. WO 2014/089290, including, but not limited to, the following, and substitutions, divisions, continuations, continuations-in-part, reissues, reexaminations, and extensions thereof: Australia Patent Nos. 2013355214;  2017204031; and  2018229489;  Canada Patent  No.  2,891,347; China Patent No. CN105142669; European Patent Nos. EP 3 138 910 B1, 3 138 911 B1, and EP 3 138 912 B1; Israel Patent No. IL238856; Singapore Patent No. 11201503824S; South Korea Patent No. 10- 1844123; and U.S. Patent Application Serial Nos. 15/188,911; 15/188,924; 15/188,927; 15/188,931; and 15/456,204 (the “Patent Rights”).

    BEFORE OPENING OR USING THIS PRODUCT, PLEASE READ THE TERMS AND CONDITIONS SET FORTH IN THIS LICENSE AGREEMENT. YOUR USE OF THIS PRODUCT SHALL CONSTITUTE ACKNOWLEDGMENT AND ACCEPTANCE OF THESE TERMS AND CONDITIONS.

    The purchase of this Product conveys to you, the Buyer, the NON-TRANSFERABLE right to use the purchased Product for Licensed Research Use (see definition below) subject to the conditions set out in this License Agreement. If you wish to use this Product for any purpose other than Licensed Research Use, you must first obtain an appropriate license (see information set out below).

    This Product may not be used for any purpose other than Licensed Research Use. Your right to use this Product for Licensed Research Use is subject to the following conditions and restrictions:

    1. Licensed Research Use means any use for research purposes, with the following exceptions: 

    i. Buyer may not sell or otherwise transfer the Product (including without limitation any material that contains the Product in whole or part) or any Related Material to any other third party (except that you may transfer the Product, including without limitation any material that contains the Product in whole or in part, or any Related Material to a bona fide collaborator or contract research person or entity), or use the Products or any Related Material to perform services for the benefit of any other person or entity;

    ii. Buyer may use only the purchased amount of the Product and components of the Product, and shall use any Related Material, only for your internal research within the Field, and not for any Commercial Purposes;

    iii. Buyer shall use the Product and any Related Material in compliance with all applicable laws and regulations, including without limitation applicable human health and animal welfare laws and regulations;

    iv. Sigma shall provide no warranties of any kind to the Buyer (statutory or implied) concerning the Patent Rights, the Product or any Related Materials, including without limitation, as to product quality, condition, description, merchantability, fitness for a particular purpose, noninfringement of intellectual property rights or the absence of latent or other defects, and all such warranties are hereby expressly disclaimed;

    v. Sigma shall expressly disclaim any warranty regarding results obtained through the use of the Product or Related Materials, including without limitation any claim of inaccurate, invalid or incomplete results;

    vi. Sigma, and their directors, officers, employees and agents, shall have no liability to the Buyer, including, without limitation, for any loss of use or profits, business interruption or any consequential, incidental, special or other indirect damages of any kind, regardless of how caused and regardless of whether an action in contract, tort, strict product liability or otherwise;

    vii. the Buyer shall indemnify, defend, and hold harmless Sigma and their current and former directors, officers, employees and agents, and their respective successors, heirs and assigns (the Indemnities) against any liability, damage, loss, or expense (including without limitation reasonable attorneys’ fees and expenses) incurred by or imposed upon any of the Indemnitees in connection with any claims, suits, investigations, actions, demands or judgments arising out of or related to the exercise of any rights granted to the Buyer hereunder or any breach of this License Agreement by such Buyer; and

    viii. the Product and its use may be the subject of one or more issued patents and/or pending patent applications owned by Sigma and the purchase of the Product does not convey a license under any claims in the foregoing patents or patent applications directed to the Licensed Product or use, production or commercialization thereof.


    For purposes of Section 1 above, the following definitions shallapply:

    Commercial Purposes means (a) the practice, performance or provision of any method, process or service, or (b) the manufacture, sale, use, distribution, disposition or importing of any product, in each case (a) or (b) for consideration, e.g., a fee, or on any other commercial basis.

    Field means use as a research tool for research purposes; provided, however, that notwithstanding the foregoing, the Field shall expressly exclude (a) any in vivo and ex vivo human or clinical use, including, without limitation, any administration into humans or any diagnostic or prognostic use, (b) the creation of transgenic rodent models and/or derivatives thereof (including, but not limited to, rodents’ cells and rodents’ organs) by for-profit entities, (c) any in vivo veterinary or livestock use, or non-research agricultural use, or (d) the manufacture, distribution, importation, exportation, transportation, sale, offer for sale, marketing, promotion or other exploitation or use of, or as, a testing service, therapeutic or diagnostic for humans or animals.


    Related Materials means any progeny, modification or derivative of a Product.

    2. Your right to use the Product will terminate immediately if you fail to comply with these terms and conditions. You shall, upon such termination of your rights, destroy all Product, Related Materials, and components thereof in your control, and notify Sigma of such in writing. For information on purchasing a license to this Product for purposes other than Licensed Research Use, contact your local Sigma sales representative, who will refer you to the proper licensing representative, or in the USA call 800-325-3010.

    Sigma-Aldrich Patent Rights:

    Patent applications and issued patents that entered their respective National Stage from PCT International Pub. No. WO 2014/089290

    Limited Use Licenses for ioNEURONS/glut - Glutamatergic Neurons

    This Product is provided by Bit Bio Ltd (Bit Bio) in partnership with Abcam plc (Abcam) under license from iPS Academia Japan, TET Systems GmbH, ERS Genomics Limited and Sigma-Aldrich Co. LLC.

    Use of the Product is restricted to the terms contained within the individual Limited Use License Notices from each of the Licensors as set out below, and also by the general restriction that the User must only use the Product, Progeny, any Modifications of the Product and any Unmodified Derivatives of the Product in the Field.

    The following Definitions apply to all Limited Use License Notices.

    Field: Internal research use only. No Commercial Use is allowed.

    Commercial Use: Any and all uses of the Product, Progeny, Modifications or Unmodified Derivatives thereof, by a party for monetary or other consideration and can include, but is not limited to use in:

    (i) Manufacture of a Product;
    (ii) Sale of a Product, Progeny, Modifications or Unmodified Derivatives thereof, whether or not such sale is limited for use in research;
    (iii) Provision of a service to a third party;
    ​(iv) Use in any diagnostic, preventative, or therapeutic application;
    (v) Use in any veterinary, livestock or agricultural application; and
    ​(vi) Use in later stage development of therapeutics, diagnostics, prophylactics (e.g., hit-to-lead, lead optimization).

    Product: Cells which are differentiated from human iPS cells by Bit Bio Ltd., and which Bit Bio Ltd. sells, or are sold on behalf of Bit Bio Ltd. by a distributor

    Progeny: Any unmodified descendant form of the Product

    Modifications: Any modifications of the Product

    Unmodified Derivatives: Any substances created by the User that constitute an unmodified functional subunit or product expressed by the Product

    User: The person or entity who purchased the Product(s) from Abcam in partnership with Bit Bio.

    iPS Academia Japan, Inc.

    The Product is sold by Abcam in partnership with Bit Bio under license from iPS Academia Japan, Inc (iPS-AJ). The Product is covered by one or more claims of issued patents and pending patent applications, including: U.S. Patent Nos. 8,048,999, 8,058,065, 8,129,187 and 8,278,104 and foreign counterparts thereof, including their divisions, continuations, extensions, substitutions, and those claiming priority therefrom or those claiming the same priorities therein.

    The use of this Product is strictly limited to User’s own internal research as described in the iPS-AJ User Restrictions Notice set out below:

    1. All Users may use the Product for internal research only including but not limited to screening potential drug compounds for efficacy and safety. No other right is granted to User whether expressly, by implication, by estoppel or otherwise. In particular, the purchase of the Product does not include nor carry any right or license to use, develop or otherwise exploit the Product commercially, and no rights are conveyed to User to use the Product for any other purpose other than specified in the Field.
    2. User agrees to use the Product in compliance with all applicable statutes and regulations, but not to use the Product for any administration or application to humans. Moreover, User agrees not to use the Product in human subjects for human clinical use for therapeutic, diagnostic or prophylactic purposes, or in animals for veterinary use for therapeutic, diagnostic or prophylactic purposes, including but not limited to clinical applications, cell therapy, transplantation, and/or regenerative medicine without an appropriate license.
    3. In the case that User transfers Product to a third party (provided such transfer is not contrary to the terms of other relevant limited use licenses relevant to the Product), User shall convey the User Restrictions set forth herein to such a third party.

    TET Systems GmbH

    This Product contains the Tetracycline controllable expression system (the "Tet Technology"). The Tet Technology IP portfolio is proprietary to TET Systems GmbH & Co. KG (''TET Systems") and comprises a series of patents including U.S. patents 8,383,364, 9,181,556, European Patents EP 1954811, 2352833 and corresponding patent claims outside these regions. The purchaser of the Product (i.e. the User) is granted an automatic license to use the Tet Technology in the Field and excludes the right to transfer or sell the Product, the Tet Technology or its component parts to third parties. Users whose research using the Product is sponsored by for-profit organizations, which shall receive ownership to any data or results stemming from the sponsored research, shall need a license agreement from TET Systems in order to use this Product.


    All Users of the Product acknowledge that the Tet Technology is experimental in nature. TET Systems makes no warranties, express or implied or of any kind, and hereby disclaims any warranties, representations, or guarantees of any kind as to the Tet Technology, patents, or products.


    Under the terms specified in the Limited Use License all Users of this Product that do not have a license from TET Systems will be restricted to the purchase of less than 10 units of Product per annum. If the User is purchasing more than 10 units of Product per annum, a TET license will be required from TET Systems GmbH & Co. KG - please contact Abcam.

    ERS GENOMICS Limited


    CRISPR Non-Exclusive License Agreement


    Certain commercial entities and/or activities performed at commercial entities may require additional contract rights from ERS Genomics Limited which are not granted through the purchase of this product. For additional information please see www.ersgenomics.com. 

    The User (purchaser) receives a non-exclusive, non-transferable right to use the Product, Progeny, Modifications and Unmodified Derivatives for RESEARCH USE ONLY, which, subject to the exclusions below, includes use to discover and develop any product, including therapeutic products, which may then be sold to third parties, provided, however, that such products do not incorporate the Product, Progeny, Modifications, or Unmodified Derivatives.


    For clarity, transfer of materials or provision of services by not for profit or academic core labs to their internal clients shall not constitute Commercial Use.


    Except for the rights granted herein, any and all rights to the Product, Progeny, Modifications or Unmodified Derivatives thereof, shall remain in Bit Bio Ltd. No ownership rights are transferred.


    The User shall have no right to assign the rights granted herein to third parties. The Product, Progeny, Modifications or Unmodified Derivatives thereof, must at all times remain in the possession of the User, except for a transfer to a scientific collaborator or to a service provider, to perform services, solely on behalf of the User.


    ERS Genomics Limited is an intended third-party beneficiary under these Terms of Use.


    Sigma-Aldrich Co. LLC


    ZFN License Agreement


    This Product and its use are the subject of one or more of the following patents controlled by Sangamo BioSciences, Inc.: U.S. Patent Nos. 6,534,261, 6,607,882, 6,746,838, 6,794,136, 6,824,978, 6,866,997,

    6,933,113, 6,979,539, 7,013,219, 7,030,215, 7,220,719, 7,241,573, 7,241,574, 7,585,849, 7,595,376,

    6,903,185, 6,479,626, US20030232410, US20090203140 and corresponding foreign patent applications and patents.


    BEFORE OPENING OR USING THIS PRODUCT, PLEASE READ THE TERMS AND CONDITIONS SET FORTH IN THIS LICENSE AGREEMENT. YOUR USE OF THIS PRODUCT SHALL CONSTITUTE ACKNOWLEDGMENT AND ACCEPTANCE OF THESE TERMS AND CONDITIONS.

    The purchase of this Product conveys to the User, the non-transferable right to use the purchased Product in the Field. If you wish to use this Product for any purpose other than Licensed Research Use, you must first obtain an appropriate license from Sigma-Aldrich Co. LLC









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