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The renin-angiotensin system functions to regulate blood pressure and fluid homeostasis. It has been extensively targeted in the treatment of cardiovascular disease, diabetic nephropathy and hypertension.1
The three major components operating in this system are
Renin is an aspartyl protease, that cleaves angiotensinogen to yield angiotensin I, which is further cleaved by Angiotensin-converting enzyme (ACE) to form Angiotensin II. Angiotensin II is the physiologically active component that promotes vasoconstriction via both direct and indirect methods.2
Angiotensin II type I receptors (AT-1) expressed on the surface of blood vessels and are activated by Angiotensin II to increase sympathetic tone and the release of vasopressin. AT-1 receptors on the kidney are stimulated to modulate renal sodium and water reabsorption, while AT-1 receptors on the adrenal glands are stimulated resulting in the release of aldosterone.
This system is homeostatically regulated by the activity of ACE2. ACE2 hydrolyzes Angiotensin II into Angiotensin 1-7 to lower blood pressure and has been identified as the cell surface receptor for the SARS-CoV-2 virus that causes COVID-19. Research concerned with this disease is now assessing the impact of infection upon this signaling pathway.3-5
Here we provide the relevant research tools to help you study the renin-angiotensin system.
|Human ACE2 ELISA kit||ab235649||ELISA|
|Recombinant Anti-ACE2 antibody [EPR4435(2)]||ab108252||IHC-P, IP, WB||Human, Mouse, Rat|
|Anti-ACE2 antibody||ab15348||IHC-P, IHC-Fr, ICC/IF, WB||Human, Macaque Monkey, Cat, Ferret, Bat|
|Recombinant Human ACE2 protein||ab151852||HPLC, SDS-PAGE||Human|
|Renin assay kit||ab138875||Enzyme activity assay||Mammals, other species|
|Human Renin ELISA kit||ab246545||ELISA||Human|
|Recombinant Anti-Renin antibody [EPR6433]||ab125012||WB, Flow cyt||Human|
|Recombinant Anti-Renin Antibody [EPR20693]||ab219127||IHC-P, IHC-Fr||Human, Mouse, Rat|
|ACE assay kit (Angiotensin I converting enzyme)||ab239703||Enzyme activity assay|
|Human ACE ELISA kit||ab263889||ELISA||Human|
|Recombinant Anti-Angiotensin Converting Enzyme 1 antibody [EPR22291-47]||ab254222||IHC-p, IHC-Fr, WB||Human, Mouse, Rat|
|Recombinant Anti-Angiotensin antibody [EPR2931]||ab108334||ICC/IF, IP, WB||Human|