Overview

  • Product name

  • Description

    Rabbit Polyclonal to COP
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human COP aa 173-197.
    Sequence:

    LHKGSLYPRIPGLGKELQTGTHKLS


    Database link: Q5EG05

  • Positive control

    • Human nasopharynx tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.2
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab188069 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
  • Tissue specificity

    Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus.
  • Sequence similarities

    Contains 1 CARD domain.
  • Information by UniProt
  • Database links

  • Alternative names

    • CAR16_HUMAN antibody
    • CARD only domain-containing protein 1 antibody
    • CARD only protein antibody
    • CARD16 antibody
    • Caspase recruitment domain family, member 16 antibody
    • Caspase recruitment domain-containing protein 16 antibody
    • Caspase-1 dominant-negative inhibitor pseudo-ICE antibody
    • Caspase-1 inhibitor COP antibody
    • COP antibody
    • COP1 antibody
    • Pseudo interleukin 1 beta converting enzyme antibody
    • Pseudo interleukin-1 beta converting enzyme antibody
    • Pseudo interleukin-1beta converting enzyme antibody
    • PSEUDO-ICE antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human nasopharynx tissue labeling COP with ab188069 at 1/20 dilution.

References

ab188069 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab188069.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up