Key features and details
- Rabbit polyclonal to COPRS/COPR5
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-COPRS/COPR5 antibody
DescriptionRabbit polyclonal to COPRS/COPR5
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
- IHC-P: Human testis, colon, prostate and skeletal muscle tissue.
This product was previously labelled as COPRS
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab185467 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
FunctionHistone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation.
- Information by UniProt
- C17orf79 antibody
- Cooperator of PRMT5 antibody
- Coordinator of PRMT5 and differentiation stimulator antibody
Immunohistochemical analysis of paraffin-embedded human testis tissue staining COPRS/COPR5 with ab185467 at 1/200 dilution.
Immunohistochemical analysis of paraffin-embedded human prostate tissue staining COPRS/COPR5 with ab185467 at 1/200 dilution.
Immunohistochemical analysis of paraffin-embedded human colon tissue staining COPRS/COPR5 with ab185467 at 1/200 dilution.
Immunohistochemical analysis of paraffin-embedded human skeletal muscle tissue staining COPRS/COPR5 with ab185467 at 1/200 dilution.
ab185467 has not yet been referenced specifically in any publications.