Anti-Corneodesmosin/S protein antibody (ab118835)
Key features and details
- Rabbit polyclonal to Corneodesmosin/S protein
- Suitable for: IHC-Fr, WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Corneodesmosin/S protein antibody
See all Corneodesmosin/S protein primary antibodies -
Description
Rabbit polyclonal to Corneodesmosin/S protein -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Fr, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human Corneodesmosin/S protein (N terminal).
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Preservative: 0.02% Sodium azide -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab118835 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-Fr |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
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Notes |
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IHC-Fr
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
Target
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Function
Important for the epidermal barrier integrity. -
Tissue specificity
Exclusively expressed in skin. -
Involvement in disease
Defects in CDSN are a cause of hypotrichosis simplex of the scalp (HTSS) [MIM:146520]; also known as hypotrichosis Spanish type. HTSS is an autosomal dominant form of isolated alopecia. Affected individuals have normal hair in early childhood but experience progressive loss of scalp hair beginning in the middle of the first decade and almost complete baldness by the third decade.
Defects in CDSN are the cause of peeling skin syndrome type B (BPSS) [MIM:270300]; also known as peeling skin syndrome or deciduous skin or keratolysis exfoliativa congenita. BPSS is a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis, associated with pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly thereafter. Several patients have been reported with high IgE levels. -
Cellular localization
Secreted. Found in corneodesmosomes, the intercellular structures that are involved in desquamation. - Information by UniProt
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Database links
- Entrez Gene: 1041 Human
- Omim: 602593 Human
- SwissProt: Q15517 Human
- Unigene: 556031 Human
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Alternative names
- AI747712 antibody
- CDSN antibody
- CDSN_HUMAN antibody
see all
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab118835 has not yet been referenced specifically in any publications.