Overview

  • Product name

    Anti-Corneodesmosin/S protein antibody
    See all Corneodesmosin/S protein primary antibodies
  • Description

    Goat polyclonal to Corneodesmosin/S protein
  • Host species

    Goat
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Chimpanzee, Rhesus monkey
  • Immunogen

    Synthetic peptide corresponding to Human Corneodesmosin/S protein aa 169-182 (internal sequence) (Cysteine residue). NP_001255.3.
    Sequence:

    QVGNGSALPTNDNS


    Database link: Q15517

  • Positive control

    • A431 cell lysate.
  • General notes

    Protein previously labeled as Corneodesmosin.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab183528 was purified from goat serum by ammonium sulfate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab183528 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 52 kDa).

Target

  • Function

    Important for the epidermal barrier integrity.
  • Tissue specificity

    Exclusively expressed in skin.
  • Involvement in disease

    Defects in CDSN are a cause of hypotrichosis simplex of the scalp (HTSS) [MIM:146520]; also known as hypotrichosis Spanish type. HTSS is an autosomal dominant form of isolated alopecia. Affected individuals have normal hair in early childhood but experience progressive loss of scalp hair beginning in the middle of the first decade and almost complete baldness by the third decade.
    Defects in CDSN are the cause of peeling skin syndrome type B (BPSS) [MIM:270300]; also known as peeling skin syndrome or deciduous skin or keratolysis exfoliativa congenita. BPSS is a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis, associated with pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly thereafter. Several patients have been reported with high IgE levels.
  • Cellular localization

    Secreted. Found in corneodesmosomes, the intercellular structures that are involved in desquamation.
  • Information by UniProt
  • Database links

  • Alternative names

    • AI747712 antibody
    • CDSN antibody
    • CDSN_HUMAN antibody
    • Corneodesmosin antibody
    • D6S586E antibody
    • DADB-141O4.5 antibody
    • Differentiated keratinocyte S protein antibody
    • HTSS antibody
    • S antibody
    • S protein antibody
    see all

Images

  • Anti-Corneodesmosin/S protein antibody (ab183528) at 1 µg/ml + A431 cell lysate (in RIPA buffer) at 35 µg

    Developed using the ECL technique.

    Predicted band size: 52 kDa

References

ab183528 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab183528.
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