• Product name

    Anti-Corneodesmosin/S protein antibody
    See all Corneodesmosin/S protein primary antibodies
  • Description

    Rabbit polyclonal to Corneodesmosin/S protein
  • Host species

  • Tested applications

    Suitable for: WB, IHC-P, IHC-Frmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Corneodesmosin/S protein (N terminal).

  • General notes

    Protein previously labeled as Corneodesmosin.



Our Abpromise guarantee covers the use of ab90517 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 51 kDa.
IHC-P Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.


  • Function

    Important for the epidermal barrier integrity.
  • Tissue specificity

    Exclusively expressed in skin.
  • Involvement in disease

    Defects in CDSN are a cause of hypotrichosis simplex of the scalp (HTSS) [MIM:146520]; also known as hypotrichosis Spanish type. HTSS is an autosomal dominant form of isolated alopecia. Affected individuals have normal hair in early childhood but experience progressive loss of scalp hair beginning in the middle of the first decade and almost complete baldness by the third decade.
    Defects in CDSN are the cause of peeling skin syndrome type B (BPSS) [MIM:270300]; also known as peeling skin syndrome or deciduous skin or keratolysis exfoliativa congenita. BPSS is a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis, associated with pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly thereafter. Several patients have been reported with high IgE levels.
  • Cellular localization

    Secreted. Found in corneodesmosomes, the intercellular structures that are involved in desquamation.
  • Information by UniProt
  • Database links

  • Alternative names

    • AI747712 antibody
    • CDSN antibody
    • CDSN_HUMAN antibody
    • Corneodesmosin antibody
    • D6S586E antibody
    • DADB-141O4.5 antibody
    • Differentiated keratinocyte S protein antibody
    • HTSS antibody
    • S antibody
    • S protein antibody
    see all


ab90517 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

1-2 of 2 Q&A


The immunogen sequence (exact sequenceis proprietary)correspondingto ab90517 is located in the N-terminal region of the Corneodesmosin protein.

Unfortunatelythe onlytwoCorneodesmosinproteinswe have in our catalogarerecombinant fragmentsthatdo not matchthe region recognised by ab90517.

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Merci de nous avoir contactés. Comme convenu j'ai mis en place l'envoi d'une unité d'anti-Corneodesmosine ab118835, le numéro de commande de remplacement gratuit de ce produit est : *****. Vous recevrez prochainement un mail de confirmation comprenant les détails d'expédition. Nous serions ravis si vous pouviez nous communiquer les résultats en ICC/IF via notre système Abreview : https://www.abcam.com/Corneodesmosin-antibody-ab118835-reviews.html. N'hésitez pas à nous contacter de nouveau si vous avez d'autres questions.

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