Overview

  • Product name

    Corosolic acid, Apoptotic agent
  • Description

    Apoptotic agent
  • Biological description

    Apoptotic agent. Ursolic acid (ab141113) derivative. Induces caspase-8, -9 and -3 activation. Decreases intracellular β-catenin levels. Shows antiproliferative effects against cancer cell lines. Shows hypoglycemic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    4547-24-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1S,2R,4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-Dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
  • Molecular weight

    472.70
  • Molecular formula

    C30H48O4
  • PubChem identifier

    6918774
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(C[C@H]([C@@H](C5(C)C)O)O)C)C)[C@@H]2[C@H]1C)C)C(=O)O
  • Source

    Lagerstroemia speciosa

  • Research areas

References

This product has been referenced in:

  • Sung B  et al. Corosolic acid induces apoptotic cell death in HCT116 human colon cancer cells through a caspase-dependent pathway. Int J Mol Med 33:943-9 (2014). Read more (PubMed: 24481288) »
  • Kim JH  et al. Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of ß-catenin degradation. Food Chem Toxicol 67:87-95 (2014). Read more (PubMed: 24566423) »
  • Feng X  et al. Microbial transformation of the anti-diabetic agent corosolic acid. Nat Prod Res 28:1879-86 (2014). Read more (PubMed: 25190540) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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