Overview

  • Product name

  • Description

    Rabbit polyclonal to Cortactin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide within Human Cortactin aa 388-437. The exact sequence is proprietary.
    Database link: Q14247

  • Positive control

    • IHC-P: Human kidney tissue. WB: HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab230910 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/33 - 1/50.
WB 1/500 - 1/1000. Predicted molecular weight: 62 kDa.

Target

  • Function

    Contributes to the organization of the actin cytoskeleton and cell structure. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.
  • Sequence similarities

    Contains 7 cortactin repeats.
    Contains 1 SH3 domain.
  • Domain

    The SH3 motif may mediate binding to the cytoskeleton.
  • Post-translational
    modifications

    Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.
  • Cellular localization

    Cytoplasm > cytoskeleton. Cell projection > lamellipodium. Cell projection > ruffle. Associated with membrane ruffles and lamellipodia.
  • Information by UniProt
  • Database links

  • Alternative names

    • Amplaxin antibody
    • CTTN antibody
    • EMS 1 antibody
    • EMS1 antibody
    • FLJ34459 antibody
    • Mammary tumor and squamous cell carcinoma associated antibody
    • Oncogene EMS1 antibody
    • p80/85 src substrate antibody
    • Src substrate cortactin antibody
    • SRC8_HUMAN antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded human kidney tissue stained for Cortactin using ab230910 at 1/33 dilution in immunohistochemical analysis.

  • All lanes : Anti-Cortactin antibody (ab230910) at 1/500 dilution

    Lane 1 : HeLa (human epithelial cell line from cervix adenocarcinoma) treated with H2O2, whole cell extract
    Lane 2 : HeLa treated with H2O2, whole cell extract with immunizing peptide

    Predicted band size: 62 kDa

References

ab230910 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab230910.
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